Genetic Iron Chelation

[ironjustice]

One might consider this .. genetic iron reduction therapy.

Genetic iron chelation protects against proteasome inhibition-induced
dopamine neuron degeneration.
Zhu W, Li X, Xie W, Luo F, Kaur D, Andersen JK, Jankovic J, Le W.
Neurobiol Dis. 2010 Feb;37(2):307-13. Epub 2009 Oct 8.
Department of Neurology, NB 205, Baylor College of Medicine, Houston,
TX 77030, USA.

Abstract
Impairment of the ubiquitin proteasome system (UPS) and iron
accumulation in the substantia nigra (SN) have both been implicated in
the pathogenesis of Parkinson's disease (PD).
We previously reported that chemical iron chelation can protect
against proteasome inhibitor lactacystin-induced dopamine (DA)
neurodegeneration in vivo.
Here, we tested potential neuroprotection via genetic expression of
the iron chelator human ferritin heavy chain (H-ferritin).
We found that overexpression of H-ferritin in DA neurons significantly
reduced lactacystin-induced nigral DA neuron loss and striatal DA
depletion.
Overexpression of H-ferritin also attenuated elevated levels of total
and ferrous iron as well as the divalent metal ion transporter 1
(DMT1) in the SN following lactacystin treatment.
In addition, overexpression of H-ferritin alleviated the inhibitory
effects of lactacystin on proteasome activity in the nigral tissues.
These results suggest that H-ferritin exerts neuroprotection possibly
by modulating iron homeostasis and restoring proteasome activity.

doi: 10.1016/j.nbd.2009.09.024.

PMID:19818853

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