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Targeting Iron In Critically Ill
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ironjustice
Dec 21, 2023, 9:50:27 PM12/21/23
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Iron as an emerging therapeutic target in critically ill patients
Coralie Grange 1 2, François Lux 3 4, Thomas Brichart 1, Laurent David 5, Aymeric Couturier 1 6, David E Leaf 7 8, Bernard Allaouchiche 9, Olivier Tillement 2
Review Crit Care . 2023 Dec 4;27(1):475. doi: 10.1186/s13054-023-04759-1.
PMID: 38049866 PMCID: PMC10694984 DOI: 10.1186/s13054-023-04759-1
https://pubmed.ncbi.nlm.nih.gov/38049866/
Abstract
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the critical role of non-transferrin bound iron (NTBI), also known as catalytic iron, in the care of critically ill patients in intensive care units (ICUs). These trace amounts of iron constitute a small percentage of the serum iron, yet they are heavily implicated in the exacerbation of diseases, primarily by catalyzing the formation of reactive oxygen species, which promote oxidative stress. Additionally, catalytic iron activates macrophages and facilitates the growth of pathogens. This review aims to shed light on this underappreciated phenomenon and explore the various common sources of NTBI in ICU patients, which lead to transient iron dysregulation during acute phases of disease. Iron serves as the linchpin of a vicious cycle in many ICU pathologies that are often multifactorial. The clinical evidence showing its detrimental impact on patient outcomes will be outlined in the major ICU pathologies. Finally, different therapeutic strategies will be reviewed, including the targeting of proteins involved in iron metabolism, conventional chelation therapy, and the combination of renal replacement therapy with chelation therapy.
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Tom
Jesus Was A Vegetarian!
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Coralie Grange 1 2, François Lux 3 4, Thomas Brichart 1, Laurent David 5, Aymeric Couturier 1 6, David E Leaf 7 8, Bernard Allaouchiche 9, Olivier Tillement 2
Review Crit Care . 2023 Dec 4;27(1):475. doi: 10.1186/s13054-023-04759-1.
PMID: 38049866 PMCID: PMC10694984 DOI: 10.1186/s13054-023-04759-1
https://pubmed.ncbi.nlm.nih.gov/38049866/
Abstract
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the critical role of non-transferrin bound iron (NTBI), also known as catalytic iron, in the care of critically ill patients in intensive care units (ICUs). These trace amounts of iron constitute a small percentage of the serum iron, yet they are heavily implicated in the exacerbation of diseases, primarily by catalyzing the formation of reactive oxygen species, which promote oxidative stress. Additionally, catalytic iron activates macrophages and facilitates the growth of pathogens. This review aims to shed light on this underappreciated phenomenon and explore the various common sources of NTBI in ICU patients, which lead to transient iron dysregulation during acute phases of disease. Iron serves as the linchpin of a vicious cycle in many ICU pathologies that are often multifactorial. The clinical evidence showing its detrimental impact on patient outcomes will be outlined in the major ICU pathologies. Finally, different therapeutic strategies will be reviewed, including the targeting of proteins involved in iron metabolism, conventional chelation therapy, and the combination of renal replacement therapy with chelation therapy.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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