Enhanced Insulin & Insulin Resistance?
Kumar
In view of following terms, can increase in insulin's exposure to
target cells by irregular food habits, by oral hypoglycemic medicines
and/or by exogenous insulin cause down-regulation of insulin receptors
resulting insulin resistance? Please give special attention to long &
very long acting insulins.
Down Regulation
http://en.wikipedia.org/wiki/Downregulation_and_upregulation
Insulin Oscillations
http://en.wikipedia.org/wiki/Insulin_oscillations
Insulin
http://en.wikipedia.org/wiki/Insulin
Insulin Degradation
http://www.ncbi.nlm.nih.gov/pubmed/9793760
Best wishes.
Kumar
Where are people for this interesting issue which may indicate true
cuprit behind insulin resistance? Obesity, Viceral obesity etc., so
thought culprits may be a saturation point to energy stores beyond
which down-regulation/IR starts. Look at it:-
"The process of downregulation occurs when there are elevated levels
of the hormone insulin in the blood."
http://en.wikipedia.org/wiki/Downregulation_and_upregulation
"The oscillations are believed to be important for insulin sensitivity
by preventing downregulation of insulin receptors in target cells."
http://en.wikipedia.org/wiki/Insulin_oscillations "
Many long acting insulins can have prolonged & constant exposure due
to slow release as also indicated here:-
""... The activity of LANTUS® results in a relatively constant
concentration/time profile over 24 hours with no pronounced peak...
Long-acting LANTUS® provides a continuous level of insulin, mimicking
the slow, steady (basal) secretion of insulin provided by the normal
pancreas. .
http://www.lantus.com/m/hcp/how/default.aspx ""
Robert Miles
news:57537b94-4e21-4e73...@f20g2000prn.googlegroups.com...
I've found newsgroup alt.support.diabetes a better source of information
about diabetes than sci.med.cardiology. Be especially wary of anything
crossposted between the sci.med.cardiology newsgroup and any of the
diabetes newsgroups, because such crossposted messages seldom
contain much if any useful information about either diabetes or cardiology.
Newsgroup misc.health.diabetes used to be a good source of information
about diabetes, before the spammers started overloading it with ads that
don't even mention diabetes.
Robert Miles
Kumar
wrote:
> "Kumar" <lordshiva5...@gmail.com> wrote in message
>
> - Show quoted text -
Thanks for suggestion.
MU
> "Kumar" <lordsh...@gmail.com> wrote in message
> news:57537b94-4e21-4e73...@f20g2000prn.googlegroups.com...
>> Hello,
>>
>> In view of following terms, can increase in insulin's exposure to
>> target cells by irregular food habits, by oral hypoglycemic medicines
>> and/or by exogenous insulin cause down-regulation of insulin receptors
>> resulting insulin resistance? Please give special attention to long &
>> very long acting insulins.
>>
>> Down Regulation
>>
>> http://en.wikipedia.org/wiki/Downregulation_and_upregulation
>>
>> Insulin Oscillations
>>
>> http://en.wikipedia.org/wiki/Insulin_oscillations
>>
>> Insulin
>>
>> http://en.wikipedia.org/wiki/Insulin
>>
>> Insulin Degradation
>>
>> http://www.ncbi.nlm.nih.gov/pubmed/9793760
>>
>> Best wishes.
>
> I've found newsgroup alt.support.diabetes a better source of information
> about diabetes than sci.med.cardiology.
> Robert Miles
Stunning news.