Cystamine (pantethine) as a suppressor of HIV
Kofi
Sulfur metabolism in AIDS: cystamine as an anti-HIV agent.
Toohey JI.
Cytoregulation Research, Elgin, Ontario, Canada.
Numerous reports have documented disturbances of sulfur metabolism in
AIDS patients. There is a generalized loss of sulfur from the body,
measured as cysteine and glutathione. The enzyme, cystathionase, has
been shown to be greatly decreased in the liver of AIDS patients.
Cystathionase is known to catalyze beta elimination of cystine giving
rise to sulfane sulphur, which has potent stimulatory properties for
lymphocytes. When both cystine and cystathionase are deficient in AIDS,
the lymphocytes would lack this important regulator, which might be
replenished by giving cystamine. Cystamine is a small disulfide that
gives rise to sulfane sulfur when it undergoes oxidation catalyzed by
diamine oxidase (a ubiquitous enzyme in animals). Cystamine has been
shown to cause marked suppression of HIV replication in cultured
lymphocytes and macrophages; the inference is that the cystamine/diamine
oxidase system may replace the cystine/cystathionase system as a source
of sulfane sulfur. Sulfane sulfur could have two beneficial effects: (1)
it could increase the vigor and resistance of the lymphocytes and (2) it
could interfere with the HIV replication process. A clinical trial of
cystamine in AIDS is indicated.
PMID: 19886835