NEWS!!! HIV/Lyme vaccine antigens suppress the immune system
Mort Zuckerman
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Subject: NEWS!!! HIV/Lyme vaccine antigens suppress the immune system
Date: Oct 26, 2009 1:22 PM
Yeah!!! WE KNOOOWW!!!
And we could have found that
out 10 years ago, as shown by
Yale's and NYMC's Gary Wormser's
shenanigans:
http://www.actionlyme.org/PresPam14_files/v3_document.htm
The mechanism starts with Pam3Cys
tolerance.
Gary Wormser:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=10865170[uid
"Hey. This vaccine doesn't do
what vaccines do. Nevermind, we'll
just call the victims of LYMErix "CRAZY"
to be saying they have the Yuppie AIDS."
http://www.ncbi.nlm.nih.gov/pubmed/19703016?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
HIV induces both a down-regulation of IRAK-4 that impairs TLR
signalling and an up-regulation of the antibiotic peptide dermcidin in
monocytic cells.
Pathak S, De Souza GA, Salte T, Wiker HG, Asjö B.
Section for Microbiology and Immunology, The Gade Institute,
University of Bergen, N-5009 Bergen, Norway.
sharad...@gades.uib.no
HIV-infected individuals have an increased risk of invasive bacterial
infections, even at early clinical stages with relatively normal CD4
(+) T-cell counts. The pathogenic mechanisms behind this are not fully
understood. However, an increasing number of studies indicate that HIV
may impair the innate immunity to bacteria by infecting key cells of
the monocyte/macrophage lineage. In this study, the effects of HIV
infection on the protein profile of undifferentiated monocyte-like
THP-1 cells were examined by a mass spectrometric approach based on
stable isotope labelling with amino acid in cell culture (SILAC). We
identified 651 proteins, of which nine proteins were down-regulated
and 17 proteins were up-regulated in HIV-infected THP-1 cells as
compared to uninfected controls. Most remarkably, the IL-1 receptor
associated kinase 4 (IRAK-4), which is essential for virtually all TLR
signalling, was suppressed, whereas the precursor for the antibiotic
peptide Dermcidin was up-regulated in HIV-infected cells. Upon
stimulation of either TLR2 or TLR4, the HIV-infected THP-1 cells
displayed reduced TNF-alpha secretion. The HIV-induced down-regulation
of IRAK-4 was reconfirmed in monocyte-derived macrophage cell
cultures. These data suggests that HIV may impair the TLR signalling
cascade for pathogen recognition in cells of the monocyte/macrophage
lineage and thus, may reduce the ability of the innate immune system
to sense invading pathogens and initiate appropriate responses.
PMID: 19703016 [PubMed - indexed for MEDLINE]
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