CDC gonna try "No Pam3Cys Vaccines" and "Structure = Function"
Mort Zuckerman
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Subject: CDC gonna try "No Pam3Cys Vaccines" and "Structure =
Function"
Date: Jan 15, 2010 4:45 AM
Oh.
Hey, I know, let's try No Pam3Cys and
Structure=Function?
"No Pam3Cys Vaccines" and "Structure = Function":
http://www.actionlyme.org/Pam3Cys_Version15.htm
http://www.actionlyme.org/PAM3CYS_IMMUNE_SUPPRESSION.htm
Wait, I GOT IT!
How about Structure=Function and No Pam3Cys
because as a TLR2 agonist, produced no antibodies
and gums up the immune system works?
Or, how about...
=========================================
http://www.ncbi.nlm.nih.gov/pubmed?term=20069123[uid]&cmd=DetailsSearch&log$=details
J Biomed Biotechnol. 2010;2010:171537. Epub 2010 Jan 4.
Cysteine-free proteins in the immunobiology of arthropod-borne
diseases.
Mejia JS, Arthun EN, Titus RG.
Department of Microbiology, Immunology and Pathology, Colorado State
University, Central Receiving, 200 W Lake Street, Campus Delivery
1619, Fort Collins, CO 80523, USA. jsm...@colostate.edu
One approach to identify epitopes that could be used in the design of
vaccines to control several arthropod-borne diseases simultaneously is
to look for common structural features in the secretome of the
pathogens that cause them. Using a novel bioinformatics technique,
cysteine-abundance and distribution analysis, we found that many
different proteins secreted by several arthropod-borne pathogens,
including Plasmodium falciparum, Borrelia burgdorferi, and eight
species of Proteobacteria, are devoid of cysteine residues. The
identification of three cysteine-abundance and distribution patterns
in several families of proteins secreted by pathogenic and
nonpathogenic Proteobacteria, and not found when the amino acid
analyzed was tryptophan, provides evidence of forces restricting the
content of cysteine residues in microbial proteins during evolution.
We discuss these findings in the context of protein structure and
function, antigenicity and immunogenicity, and host-parasite
relationships.
PMID: 20069123 [PubMed - in process]
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