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MEDLINE: Hospital-Acquired LYMErix Disease (TLR2-agonist Staph aureus)

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Mort Zuckerman

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Jun 3, 2010, 6:59:56 AM6/3/10
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Subject: MEDLINE: Hospital-Acquired LYMErix Disease (TLR2-agonist
Staph aureus)

Date: Jun 3, 2010 6:58 AM

Yet another disaster directly
attributable to IDSA's lies about
Lyme and LYMErix.

http://www.actionlyme.org
----------------------------------------------

http://www.ncbi.nlm.nih.gov/pubmed?term=tlr2[All%20Fields]%20AND%20%28%22staphylococcal%20infections%22[MeSH%20Terms]%20OR%20%28%22staphylococcal%22[All%20Fields]%20AND%20%22infections%22[All%20Fields]%29%20OR%20%22staphylococcal%20infections%22[All%20Fields]%20OR%20%22staph%22[All%20Fields]%29%20AND%20aureus[All%20Fields]&cmd=DetailsSearch

L-17 is essential for host defense against cutaneous Staphylococcus
aureus infection in mice.

Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR,
Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL,
Miller LS.

J Clin Invest. 2010 May 3;120(5):1762-73. doi: 10.1172/JCI40891. Epub
2010 Apr 1.PMID: 20364087 [PubMed - indexed for MEDLINE]Free PMC
ArticleFree textRelated citations
2.

TLR2 signalling: At the crossroads of commensalism, invasive
infections and toxic shock syndrome by Staphylococcus aureus.

Mele T, Madrenas J.

Int J Biochem Cell Biol. 2010 Jul;42(7):1066-1071. Epub 2010 Apr
2.PMID: 20363358 [PubMed - as supplied by publisher]Related citations
3.

Artesunate protects sepsis model mice challenged with Staphylococcus
aureus by decreasing TNF-alpha release via inhibition TLR2 and Nod2
mRNA expressions and transcription factor NF-kappaB activation.

Li B, Li J, Pan X, Ding G, Cao H, Jiang W, Zheng J, Zhou H.

Int Immunopharmacol. 2010 Mar;10(3):344-50. Epub 2009 Dec 11.PMID:
20005985 [PubMed - indexed for MEDLINE]Related citations
4.

Toll-like receptor 2 ligand-induced protection against bacterial
endophthalmitis.

Kumar A, Singh CN, Glybina IV, Mahmoud TH, Yu FS.

J Infect Dis. 2010 Jan 15;201(2):255-63.PMID: 19995266 [PubMed -
indexed for MEDLINE]Related citations
5.

Dysregulation of CD36 upon TLR-2 stimulation in monocytes from
patients with atopic dermatitis and the TLR2 R753Q polymorphism.

Niebuhr M, Langnickel J, Sigel S, Werfel T.

Exp Dermatol. 2009 Oct 22. [Epub ahead of print]PMID: 19849713 [PubMed
- as supplied by publisher]Related citations
6.

Staphylococcal lipoproteins and their role in bacterial survival in
mice.

Schmaler M, Jann NJ, Götz F, Landmann R.

Int J Med Microbiol. 2010 Feb;300(2-3):155-60. Epub 2009 Oct 4.
Review.PMID: 19805005 [PubMed - indexed for MEDLINE]Related citations
7.

Toll-like receptors in brain abscess.

Esen N, Kielian T.

Curr Top Microbiol Immunol. 2009;336:41-61. Review.PMID: 19688327
[PubMed - indexed for MEDLINE]Related citations
8.

Impaired osteoclastogenesis by staphylococcal lipoteichoic acid
through Toll-like receptor 2 with partial involvement of MyD88.

Yang J, Ryu YH, Yun CH, Han SH.

J Leukoc Biol. 2009 Oct;86(4):823-31. Epub 2009 Jul 14.PMID: 19602669
[PubMed - indexed for MEDLINE]Related citations
9.

NOD2 contributes to cutaneous defense against Staphylococcus aureus
through alpha-toxin-dependent innate immune activation.

Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M,
Nizet V, Eckmann L.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12873-8. Epub 2009 Jun
16.PMID: 19541630 [PubMed - indexed for MEDLINE]Free PMC ArticleFree
textRelated citations
10.

Lipoproteins in Staphylococcus aureus mediate inflammation by TLR2 and
iron-dependent growth in vivo.

Schmaler M, Jann NJ, Ferracin F, Landolt LZ, Biswas L, Götz F,
Landmann R.

J Immunol. 2009 Jun 1;182(11):7110-8.PMID: 19454708 [PubMed - indexed
for MEDLINE]Related citations
11.

The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and -4
are induced in synovial membranes in case of septic arthritis.

Varoga D, Klostermeier E, Paulsen F, Wruck C, Lippross S, Brandenburg
LO, Tohidnezhad M, Seekamp A, Tillmann B, Pufe T.

Virchows Arch. 2009 Jun;454(6):685-94. Epub 2009 May 3.PMID: 19412702
[PubMed - indexed for MEDLINE]Related citations
12.

Staphylococcus aureus accelerates an experimental allergic
conjunctivitis by Toll-like receptor 2-dependent manner.

Chung SH, Nam KH, Kweon MN.

Clin Immunol. 2009 Apr;131(1):170-7.PMID: 19358332 [PubMed - indexed
for MEDLINE]Related citations
13.

Innate immune-induced depletion of bone marrow neutrophils aggravates
systemic bacterial infections.

Navarini AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V,
Odermatt B, Hengartner H, Zinkernagel RM.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7107-12. Epub 2009 Apr
7.PMID: 19351895 [PubMed - indexed for MEDLINE]Free PMC ArticleFree
textRelated citations
14.

Pretreatment with the Gram-positive bacterial cell wall molecule
peptidoglycan improves bacterial clearance and decreases inflammation
and mortality in mice challenged with Staphylococcus aureus.

Murphey ED, Fang G, Sherwood ER.

Crit Care Med. 2008 Nov;36(11):3067-73.PMID: 18824898 [PubMed -
indexed for MEDLINE]Free PMC ArticleFree textRelated citations
15.

Innate immune responses of epididymal epithelial cells to
Staphylococcus aureus infection.

Zhao YT, Guo JH, Wu ZL, Xiong Y, Zhou WL.

Immunol Lett. 2008 Aug 15;119(1-2):84-90. Epub 2008 Jun 4.PMID:
18571736 [PubMed - indexed for MEDLINE]Related citations
16.

Escherichia coli, but not Staphylococcus aureus triggers an early
increased expression of factors contributing to the innate immune
defense in the udder of the cow.

Petzl W, Zerbe H, Günther J, Yang W, Seyfert HM, Nürnberg G, Schuberth
HJ.

Vet Res. 2008 Mar-Apr;39(2):18. Epub 2008 Jan 29.PMID: 18258172
[PubMed - indexed for MEDLINE]Free ArticleRelated citations
17.

Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus
aureus and E. coli, but S. aureus fails to both activate NF-kappaB in
mammary epithelial cells and to quickly induce TNFalpha and
interleukin-8 (CXCL8) expression in the udder.

Yang W, Zerbe H, Petzl W, Brunner RM, Günther J, Draing C, von Aulock
S, Schuberth HJ, Seyfert HM.

Mol Immunol. 2008 Mar;45(5):1385-97. Epub 2007 Oct 22.PMID: 17936907
[PubMed - indexed for MEDLINE]Related citations
18.

Minocycline modulates neuroinflammation independently of its
antimicrobial activity in staphylococcus aureus-induced brain abscess.

Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, Phillips N, Nishina K,
Cheung AL, Schwartzman JD, Ruhe JJ.

Am J Pathol. 2007 Oct;171(4):1199-214. Epub 2007 Aug 23.PMID: 17717149
[PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated
citations
19.

Suppression of innate immunity by a nasal carriage strain of
Staphylococcus aureus increases its colonization on nasal epithelium.

Quinn GA, Cole AM.

Immunology. 2007 Sep;122(1):80-9. Epub 2007 Apr 30.PMID: 17472720
[PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated
citations
20.

The role of TLR2 in vivo following challenge with Staphylococcus
aureus and prototypic ligands.

Mullaly SC, Kubes P.

J Immunol. 2006 Dec 1;177(11):8154-63.PMID: 17114491 [PubMed - indexed
for MEDLINE]Free ArticleRelated citations
21.

Staphylococcus aureus-induced corneal inflammation is dependent on
Toll-like receptor 2 and myeloid differentiation factor 88.

Sun Y, Hise AG, Kalsow CM, Pearlman E.

Infect Immun. 2006 Sep;74(9):5325-32.PMID: 16926427 [PubMed - indexed
for MEDLINE]Free PMC ArticleFree textRelated citations
22.

Cathepsin E-deficient mice show increased susceptibility to bacterial
infection associated with the decreased expression of multiple cell
surface Toll-like receptors.

Tsukuba T, Yamamoto S, Yanagawa M, Okamoto K, Okamoto Y, Nakayama KI,
Kadowaki T, Yamamoto K.

J Biochem. 2006 Jul;140(1):57-66.PMID: 16877769 [PubMed - indexed for
MEDLINE]Related citations
23.

Induction of beta-defensin 3 in keratinocytes stimulated by bacterial
lipopeptides through toll-like receptor 2.

Sumikawa Y, Asada H, Hoshino K, Azukizawa H, Katayama I, Akira S,
Itami S.

Microbes Infect. 2006 May;8(6):1513-21. Epub 2006 Apr 7.PMID: 16697678
[PubMed - indexed for MEDLINE]Related citations
24.

Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human
neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-
independent mechanism: Autocrine role of tumor necrosis factor-[alpha]
in mediating LTA-induced interleukin-8 generation.

Hattar K, Grandel U, Moeller A, Fink L, Iglhaut J, Hartung T, Morath
S, Seeger W, Grimminger F, Sibelius U.

Crit Care Med. 2006 Mar;34(3):835-41.PMID: 16521278 [PubMed - indexed
for MEDLINE]Related citations
25.

TLR2 is required for the altered transcription of p75NGF receptors in
gram positive infection.

Wirz SA, Tobias PS, Ulevitch RJ, Aribibe L, Bartfai T.

Neurochem Res. 2006 Feb;31(2):297-301. Epub 2006 Mar 3.PMID: 16518575
[PubMed - indexed for MEDLINE]Related citations
26.

Protection of Staphylococcus aureus-infected septic mice by
suppression of early acute inflammation and enhanced antimicrobial
activity by ginsan.

Ahn JY, Song JY, Yun YS, Jeong G, Choi IS.

FEMS Immunol Med Microbiol. 2006 Mar;46(2):187-97.PMID: 16487300
[PubMed - indexed for MEDLINE]Related citations
27.

MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2
activation in immunity against Staphylococcus aureus.

Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross
CE, Thirumala A, Cheung AL, Cheng G, Modlin RL.

Immunity. 2006 Jan;24(1):79-91.PMID: 16413925 [PubMed - indexed for
MEDLINE]Related citations
28.

IL-1 can act as number one.

Gamero AM, Oppenheim JJ.

Immunity. 2006 Jan;24(1):16-7.PMID: 16413919 [PubMed - indexed for
MEDLINE]Related citations
29.

Toll-like receptor 2 modulates the proinflammatory milieu in
Staphylococcus aureus-induced brain abscess.

Kielian T, Haney A, Mayes PM, Garg S, Esen N.

Infect Immun. 2005 Nov;73(11):7428-35.PMID: 16239543 [PubMed - indexed
for MEDLINE]Free PMC ArticleFree textRelated citations
30.

A toll-like receptor 2-responsive lipid effector pathway protects
mammals against skin infections with gram-positive bacteria.

Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S,
Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC,
Beutler B.

Infect Immun. 2005 Aug;73(8):4512-21.PMID: 16040962 [PubMed - indexed
for MEDLINE]Free PMC ArticleFree textRelated citations
31.

Recognition of Staphylococcus aureus by the innate immune system.

Fournier B, Philpott DJ.

Clin Microbiol Rev. 2005 Jul;18(3):521-40. Review.PMID: 16020688
[PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated
citations
32.

Oral delivery and gastrointestinal absorption of soluble glucans
stimulate increased resistance to infectious challenge.

Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart
BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, Ensley HE, Brown
GD, Gordon S, Williams DL.

J Pharmacol Exp Ther. 2005 Sep;314(3):1079-86. Epub 2005 Jun 23.PMID:
15976018 [PubMed - indexed for MEDLINE]Free ArticleRelated citations
33.

Toll-like receptor 2 expression on human conjunctival epithelial
cells: a pathway for Staphylococcus aureus involvement in chronic
ocular proinflammatory responses.

Cook EB, Stahl JL, Esnault S, Barney NP, Graziano FM.

Ann Allergy Asthma Immunol. 2005 Apr;94(4):486-97.PMID: 15875531
[PubMed - indexed for MEDLINE]Related citations
34.

[Differential modulation of TLR2 and TLR4-induced TNF production by
murin haemorrhagic shock]

Asehnoune K, Moine P, Fitting C, Benhamou D, Cavaillon JM, Edouard A.

Ann Fr Anesth Reanim. 2005 Mar;24(3):255-9. Epub 2005 Jan 21. French.
PMID: 15792558 [PubMed - indexed for MEDLINE]Related citations
35.

Bacterial and host factors implicated in nasal carriage of methicillin-
resistant Staphylococcus aureus in mice.

González-Zorn B, Senna JP, Fiette L, Shorte S, Testard A, Chignard M,
Courvalin P, Grillot-Courvalin C.

Infect Immun. 2005 Mar;73(3):1847-51.PMID: 15731086 [PubMed - indexed
for MEDLINE]Free PMC ArticleFree textRelated citations
36.

CD36 is a sensor of diacylglycerides.

Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S,
Shamel L, Hartung T, Zähringer U, Beutler B.

Nature. 2005 Feb 3;433(7025):523-7.PMID: 15690042 [PubMed - indexed
for MEDLINE]Related citations
37.

Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus
peptidoglycan but not intact bacteria by microglia.

Kielian T, Esen N, Bearden ED.

Glia. 2005 Mar;49(4):567-76.PMID: 15593098 [PubMed - indexed for
MEDLINE]Free PMC ArticleFree textRelated citations
38.

Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial
dysfunction and cytokine production in the heart.

Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson
HS, Takeuchi O, Akira S, Vallejo JG.

Circulation. 2004 Dec 14;110(24):3693-8. Epub 2004 Nov 29.PMID:
15569836 [PubMed - indexed for MEDLINE]Free ArticleRelated citations
39.

Lack of association between Toll-like receptor 2 polymorphisms and
susceptibility to severe disease caused by Staphylococcus aureus.

Moore CE, Segal S, Berendt AR, Hill AV, Day NP.

Clin Diagn Lab Immunol. 2004 Nov;11(6):1194-7.PMID: 15539529 [PubMed -
indexed for MEDLINE]Free PMC ArticleFree textRelated citations
40.

Toll-like receptors in rat brains injured by hypoxic-ischaemia or
exposed to staphylococcal alpha-toxin.

Maślińska D, Laure-Kamionowska M, Maśliński S.

Folia Neuropathol. 2004;42(3):125-32.PMID: 15535030 [PubMed - indexed
for MEDLINE]Related citations
41.

Three different neutrophil subsets exhibited in mice with different
susceptibilities to infection by methicillin-resistant Staphylococcus
aureus.

Tsuda Y, Takahashi H, Kobayashi M, Hanafusa T, Herndon DN, Suzuki F.

Immunity. 2004 Aug;21(2):215-26.PMID: 15308102 [PubMed - indexed for
MEDLINE]Related citations
42.

Toll-like receptor expression in human keratinocytes: nuclear factor
kappaB controlled gene activation by Staphylococcus aureus is toll-
like receptor 2 but not toll-like receptor 4 or platelet activating
factor receptor dependent.

Mempel M, Voelcker V, Köllisch G, Plank C, Rad R, Gerhard M, Schnopp
C, Fraunberger P, Walli AK, Ring J, Abeck D, Ollert M.

J Invest Dermatol. 2003 Dec;121(6):1389-96.PMID: 14675188 [PubMed -
indexed for MEDLINE]Free ArticleRelated citations
43.

Alanylation of teichoic acids protects Staphylococcus aureus against
Toll-like receptor 2-dependent host defense in a mouse tissue cage
infection model.

Kristian SA, Lauth X, Nizet V, Goetz F, Neumeister B, Peschel A,
Landmann R.

J Infect Dis. 2003 Aug 1;188(3):414-23. Epub 2003 Jul 10.PMID:
12870123 [PubMed - indexed for MEDLINE]Related citations
44.

[Potential role of JAK/STAT in regulating Toll-like receptor 2 gene
expression in rats with postburn Staphylococcus aureus sepsis]

Li HY, Yao YM, Yao S, Dong N, Yu Y, Sheng ZY.

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Mar;15(3):139-42. Chinese.
PMID: 12831613 [PubMed - indexed for MEDLINE]Related citations
45.

Characterization of microglial responses to Staphylococcus aureus:
effects on cytokine, costimulatory molecule, and Toll-like receptor
expression.

Kielian T, Mayes P, Kielian M.

J Neuroimmunol. 2002 Sep;130(1-2):86-99.PMID: 12225891 [PubMed -
indexed for MEDLINE]Related citations
46.

Induction of cytokine production in human T cells and monocytes by
highly purified lipoteichoic acid: involvement of Toll-like receptors
and CD14.

Ellingsen E, Morath S, Flo T, Schromm A, Hartung T, Thiemermann C,
Espevik T, Golenbock D, Foster D, Solberg R, Aasen A, Wang J.

Med Sci Monit. 2002 May;8(5):BR149-56.PMID: 12011760 [PubMed - indexed
for MEDLINE]Related citations
47.

Platelet-activating factor receptor and ADAM10 mediate responses to
Staphylococcus aureus in epithelial cells.

Lemjabbar H, Basbaum C.

Nat Med. 2002 Jan;8(1):41-6.PMID: 11786905 [PubMed - indexed for
MEDLINE]Related citations
48.

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly
susceptible to Staphylococcus aureus infection.

Takeuchi O, Hoshino K, Akira S.

J Immunol. 2000 Nov 15;165(10):5392-6.PMID: 11067888 [PubMed - indexed
for MEDLINE]Free ArticleRelated citations

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