New report on the reason for ceftriaxone-treatment failure of "Lyme Disease"
Kathleen
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Subject: New report on the reason for ceftriaxone-treatment failure of
"Lyme Disease"
\
Date: Aug 20, 2010 4:23 AM
Identical to the old, 1992 Klempner
report:
http://www.ncbi.nlm.nih.gov/pubmed/1634816
New:
http://www.ncbi.nlm.nih.gov/pubmed/20718718
APMIS. 2010 Sep 1;118(9):665-73.
Persistence of borrelial DNA in the joints of Borrelia burgdorferi-
infected mice after ceftriaxone treatment.
Yrjänäinen H, Hytönen J, Hartiala P, Oksi J, Viljanen MK.
Departments of Medical Microbiology and Immunology, University of
Turku, Turku, Finland.
Abstract
Yrjänäinen H, Hytönen J, Hartiala P, Oksi J, Viljanen MK. Persistence
of borrelial DNA in the joints of Borrelia burgdorferi-infected mice
after ceftriaxone treatment. APMIS 2010; 118: 665-73. We have earlier
shown that Borrelia burgdorferi-infected and ceftriaxone-treated mice
have viable spirochetes in their body, since immunosuppressive
treatment allows B. burgdorferi to be detected by culture. However,
the niche of the persisting spirochetes remained unknown. In the
present study, we analyzed the tissues of B. burgdorferi-infected and
ceftriaxone-treated mice by culture and PCR to reveal the foci of
persisting spirochetes. C3H/HeN mice were infected via intradermal
needle injection with B. burgdorferi s.s. N40. The mice were treated
as follows: (i) short (5 days) and (ii) long (18 days) course of
ceftriaxone at 2 weeks of infection and killed after either 10 or 30
weeks, or (iii) the mice received ceftriaxone for 5 days at 18 weeks
of infection and were killed 21 weeks after the treatment. All samples
of ceftriaxone-treated mice were culture negative, whereas all
untreated controls were culture positive. Importantly, B. burgdorferi
DNA was detected in the joints of 30-100% of the treated mice. In
conclusion, these results combined with earlier results suggest that
the joint or a tissue adjacent to the joint is the niche of persisting
B. burgdorferi in ceftriaxone-treated mice.
==========================
http://www.actionlyme.org/Mark_Klempner_Fibroblasts.htm
Full Text ^^^
Also says something about culturing
which we (IDSA) know takes months and not
weeks, and we knew it in 1989 (Russell
Johnson):
http://www.actionlyme.org/CHP_9_IDSA_REVIEWS.htm
You can't kill spirochetes:
http://www.actionlyme.org/BRAIN_PERMANENT.htm
The reason is that they;re intracellular
and go into the cyst form in dormancy
and in adverse conditions, OTA "starvation
forms."
KMDickson
Lipanj
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> Full Text ^^^
>
> Also says something about culturing
> which we (IDSA) know takes months and not
> weeks, and we knew it in 1989 (Russell
> Johnson):http://www.actionlyme.org/CHP_9_IDSA_REVIEWS.htm
>
> You can't kill spirochetes:http://www.actionlyme.org/BRAIN_PERMANENT.htm
>
> The reason is that they;re intracellular
> and go into the cyst form in dormancy
> and in adverse conditions, OTA "starvation
> forms."
>
> http://www.relapsingfever.org
>
> KMDickson
http://www.actionlyme.org/Mark_Klempner_Fibroblasts.htm
Yes read this article: web site above - from about 1990-1991 one of
the authors is KLEMPER - hmmm sure now it is hard to catch and easy to
treat... or oh it must be something else like post lyme
syndrome------and once you are treated all the bacteria is gone.....
Mort Zuckerman
Gone means intracellular and
into the multiply-dividing form, the cyst
form
LOL
J