Doxycycline only works for the Allen Steere kinda HLA-Lyme
Mort Zuckerman
Durlan...@yale.edu, Aa...@columbia.edu, gary_w...@nymc.edu,
scientifi...@ostp.gov, pkru...@princeton.edu,
Stanle...@fiu.edu, emcsw...@niaid.nih.gov, afa...@niaid.nih.gov,
Spin...@yahoogroups.com, kshe...@calea.org, fit...@gmail.com,
patrick.f...@usdoj.gov, model...@sbcglobal.net,
jdr...@nejm.org, let...@courant.com, Jgerb...@cdc.gov,
michae...@po.state.ct.us, con...@po.state.ct.us, executive-
edi...@nytimes.com, managin...@nytimes.com, news-
ti...@nytimes.com, biz...@nytimes.com, for...@nytimes.com,
nati...@nytimes.com, dv...@cdc.gov, brigidc...@optonline.net,
tr...@hotmail.com, illino...@aol.com, jle...@courant.com,
tinaj...@yahoo.com, jhorn...@fff.org, thomas...@usdoj.gov,
thoma...@po.state.ct.us, kur...@washpost.com,
georg...@washpost.com, p...@allegorypress.com,
commissi...@po.state.ct.us, brans...@comcast.net,
vts...@comcast.net, o...@po.state.ct.us, freet...@charter.net,
scott....@po.state.ct.us, govern...@po.state.ct.us,
attorney...@po.state.ct.us, randall...@usdoj.gov,
Robert....@yale.edu, edi...@greenwich-post.com,
harol...@yale.edu, sedm...@nswbc.org, rrmcg...@aol.com,
fr...@nytimes.com, dpr...@stmartin.edu
Cc: fra...@ucia.gov, dr-ahma...@president.ir,
eugener...@washpost.com, afa...@niaid.nih.gov,
bmi...@newstimes.com, tr...@hotmail.com, rast...@aol.com,
billc...@gmail.com, amcg...@rms-law.com, rjmu...@aol.com,
paulcrai...@yahoo.com, criminal...@usdoj.gov,
karla.d...@usdoj.gov, christophe...@usdoj.gov,
richar...@yale.edu, harol...@yale.edu, james.p...@yale.edu,
inq...@aldf.com, ly...@idsociety.org, meganm...@theatlantic.com
Subject: [SpinLyme] Doxycycline only works for the Allen Steere kinda
HLA-Lyme
Date: Mar 16, 2010 7:46 AM
This means Klempner/Doxy does not
apply for people who don't only have
the Bad Knees/Autoreactive to OspA
kinda Lyme. In other words, Doxy does
not work for neurologic Lyme or
the New Great Imitators: Lupus,
MS, ALS...
http://www.ncbi.nlm.nih.gov/pubmed/14766355
Front Biosci. 2004 Jan 1;9:154-8.
The relationship of HLA antigens to doxycycline induced apoptosis in
immortalized B cells.
Wang P, Dorante G, Powell SR, Hilton E.
Department of Medicine, Long Island Jewish Medical Center, New Hyde
Park, New York 11040, USA. pw...@lij.edu
Previous studies have shown two subsets of Lyme disease (LD) patients:
a seropositive group with a high frequency of the HLA class II
antigen, HLA-DR7 (DR7+), and a seronegative group with a low frequency
of HLA-DR7 (DR7-). The present study examined the hypothesis that the
absence or presence of this antigen may play a role in the mode of B
cell death induced by doxycycline. B cells, obtained from one HLA-DR7-
(AL7N) and one HLA-DR7+ (MM7P) normal volunteers, were immortalized
using Epstein-Barr Virus (EBV). Doxycycline resulted in a dose-
dependent decrease in cell viability which was not different between
the two cell lines. DNA from the MM7P showed a strong internucleosomal
fragmentation pattern consistent with apoptosis, while the AL7N showed
a weaker pattern, when treated with doxycycline, 20 ug/ml, for 16
hours, a result confirmed with the TUNEL assay. In the MM7P, the level
of inducible p53 peaked at 8 hours while no changes were observed in
the AL7N. A much higher level of HLA class II and HLA-DR was observed
in the AL7N cell line which was not affected by doxycycline. These
results support the conclusion that doxycycline induces p53-dependent
apoptosis in MM7P. Although doxycycline induces death in AL7N, the
mode and mechanism require further study.
PMID: 14766355 [PubMed - indexed for MEDLINE]
"[Real] scientists are *fiercely* independent. That's the good
news."-- NIH's Top Fool, Anthony Fauci
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/SpinLyme/