New: Mechanisms of BBB injury in LYMErix Disease
Mort Zuckerman
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Subject: New: Mechanisms of BBB injury in LYMErix Disease
Date: Jul 18, 2010 12:28 PM
LYMErix-Disease:
http://www.actionlyme.org/Pam3Cys_Version15.htm
Report below is consistent with IDSA's reported
biomarkers of disease:
http://www.actionlyme.org/BIOMARKERS2.htm
http://www.actionlyme.org/070430.htm
Nice.
And timely because clearly the CDC,
the AMA, and Kaiser have no clue what
the hell they're talking about:
http://health.usnews.com/health-news/managing-your-healthcare/research/articles/2010/07/18/many-false-positive-hiv-test-results-for-those-in-aids-vaccine-trials.html
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http://www.ncbi.nlm.nih.gov/pubmed/20613638
J Neuropathol Exp Neurol. 2010 Jul 7. [Epub ahead of print]
HIV-1 gp120-Induced Injury to the Blood-Brain Barrier: Role of
Metalloproteinases 2 and 9 and Relationship to Oxidative Stress.
Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS.
From the Department of Pathology, Anatomy and Cell Biology (J-PL, LA,
DSS), and Department of Neurosurgery, Farber Institute for
Neurosciences (BASR, EJVB), Thomas Jefferson University, Philadelphia,
Pennsylvania.
Abstract
Blood-brain barrier (BBB) disruption occurs during human
immunodeficiency virus encephalopathy, but the mechanisms involved are
not understood. We studied how acute and ongoing exposure to human
immunodeficiency virus 1 envelope gp120 alters BBB structure and
permeability. Intravenous Evans blue, given before stereotaxic gp120
injection into the caudate putamen of rats, was rapidly extravasated.
Gelatinolytic activity, studied by in situ zymography, was increased
after gp120 administration and was localized within cerebralvessel
walls. The gp120 increased the expression of matrix metalloproteinases
(MMPs) 2 and 9. Laminin and claudin-5, key BBB components and targets
of both MMPs, were greatly reduced upon gp120 administration. The
gp120 increased lipid peroxidation in the vascular endothelium and in
neurons. Prior administration of rSV40 vectors carrying the
antioxidant enzymes Cu/Zn superoxide dismutase or glutathione
peroxidase protected from gp120-induced BBB damage. N-methyl-D-
aspartate receptor activation upregulated pro-MMP-9 and increased
MMP-9 gelatinase activity, and memantine, an N-methyl-D-aspartate
receptor blocker, mitigated gp120-induced BBB abnormalities. Using
intra-caudate putamen SV(gp120) to test the effects of chronic
exposure to expressed gp120, we determined that oxidant stress and
increased BBB permeability occurred as in acute exposure. These data
indicate that both direct administration and cellular expression of
gp120 lead to disruption of the BBB by ***increasing MMPs and reducing
vascular tight junction proteins via mechanisms involving reactive
oxygen species generation and oxidant injury.***
KMDickson
Lipanj
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>
> Subject: New: Mechanisms of BBB injury in LYMErix Disease
>
> Date: Jul 18, 2010 12:28 PM
>
> LYMErix-Disease:http://www.actionlyme.org/Pam3Cys_Version15.htm
>
> Report below is consistent with IDSA's reported
>
> Nice.
>
> And timely because clearly the CDC,
> the AMA, and Kaiser have no clue what
this article is sicko: "scientists" no nothings 'Job security" a
new idiot project.
And timely because clearly the CDC,
the AMA, and Kaiser have no clue what
the hell they're talking about:
http://health.usnews.com/health-news/managing-your-healthcare/researc...
===========================================