Anti-Tick-Saliva Vaccine- URI's gig since at least 2002
Mort Zuckerman
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Subject: Anti-Tick-Saliva Vaccine- URI's gig since at least 2002
Date: Nov 19, 2009 8:11 AM
http://www.uri.edu/news/releases/html/02-0408.html
Yale got a grant for this research
*after* URI made the claim. Tom Mather.
Joe Lieberman blew his own horn
over the matter, and of course,
all along ignored us.
Meanwhile, URI-Brown got a 13.5
million dollar grant the day before
Alison DeLong blew Klempner out of
the water at IDSA sham of a forum:
http://www.idsociety.org/Content.aspx?id=15026
DeLong ^^ completely trashed Klempner's
http://www.actionlyme.org/MKLEMPNER.htm
excuse for "science," so we wonder how
now IDSA will release "guidelines" on
"Lyme Disease," especially now that they
can no longer call OspA/Pam3Cys a vaccine,
it so reliably mutates B cells that the
whole vaccine world was turned upside
down because of it and Anthony Fauci had
to call himself, "idiot."
http://www.actionlyme.org
The whole SCAM was about falsifying
the results of OspA:
http://www.actionlyme.org/DICKSON_FDA_SUBMISSION_FULL.htm
That happens to be why Steere went
to Europe to falsify the Lyme testing
standard, like this:
http://www.relapsingfever.org
Steere changed his own diagnostic
standard on himself:
http://www.actionlyme.org/CRYMEDISEASE_CHP3_B.htm
http://www.actionlyme.org/CDC_DOCUMENTS_1990.htm
That ^^^ Lyme should be viewed as a
Relapsing Fever organism was Steere's
first idea and the CDC adopted that
standard in 1990.
Then came the OspA vaccine patents, and
in the mouse trials, these crooks realized
they could not read their Western Blots in
LYMErix vaccinated mammals, and that, OspA
failed to protect against Lyme, AND THAT,
"Chronic Lyme was indistinguishable from
Lyme Vaccine Failure"- Dave Persing (more
about that below).
Steere went to Europe in 1992:
http://www.actionlyme.org/STEERE_IN_EUROPE.htm
with bogus strains and recombinant
OspA from strain B31, which is known
in the real world of science as SCIENTIFIC
FRAUD.
You know for sure from this 1993 report:
http://info.med.yale.edu/eph/vectorbio/fish/BarbourFish.pdf
It was ^^^all about promoting the vaccines
while trashing us, their victims and their
intended LYMErix victims:
"Despite these discouraging considerations, demand for preventive
measures against Lyme disease has prompted efforts to develop a human
vaccine for the disease [95]. One justification for this effort is the
accumulated evidence over the last decade that the morbidity from B.
burgdorferi infection in highly endemic areas is considerable; in some
areas, 10% of the population has been infected [96]. ***Some patients
with Lyme disease involving the joints or nervous system do not
improve substantially even after parenteral antibiotic therapy
[69-71,97].***
Although doubts remain about many diagnoses of chronic Lyme disease,
the specter of a large number of persons with unrelieved disabilities
prompts further consideration of a B. burgdorferi vaccine for high-
risk populations, such as outdoor workers and residents of endemic
areas.
The feasibility of a human vaccine was demonstrated with experimental
infections of animals."
- - -
Here are several articles where the
same perps talk about OspA FAILURE:
http://www.actionlyme.org/FUNGAL_VACCINES.htm
Fikrig, 1992 (and 1990):
http://www.actionlyme.org/CENTRAL_LYME_RICO_PATENTS.htm
Persing in the RICO patent, discussing
Fikrig's report on vaccine failure:
http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6045804.PN.&OS=PN/6045804&RS=PN/6045804
"Additional uncertainty may arise if the vaccines are not completely
protective; vaccinated patients with multisystem complaints
characteristic of later presentations of Lyme disease may be difficult
to distinguish from patients with vaccine failure. Vaccine failures
have been occasionally noted in animal models (E. Fikrig et al.,
Science, 250, 553-6 (1990)), and infection with antigenically variant
strains of B. burgdorferi, which are being increasingly documented in
the U.S., might still occur."
When you're playing a DNA/RNA shell
game, of course you're not going
to find what you don't want to
find:
http://www.actionlyme.org/PRIMERSHELLGAME.htm
You can ^^ see that Gary Wormser used
proper primers when he reported
that treatment of tick bite
failed in 2/9 cases, while simultaneously,
in the same report, he reported that ALL
cases of treatment were successful.
The guy is just plain looney toons.
All of their work will have to be
thrown out because of crap like
this and even Willy Burgdofer says
so:
http://underourskin.com/blog/?p=191
"Don't look at Steere's work.
Start over."-- Willy Burgdorfer.
Does the OspA gene mutate?
I don't know. Let's ask Alan Barbour:
http://www.actionlyme.org/BARBOUR_MUTANTS_1992.htm
"Oh, yes, I me Alan Barbour am referencing
THREE reports which shows we know OspA
mutates and should not be used as
a vaccine, therefore."
And these Pam3Cys/OspA antigens mutate
B cells (inhibit the autokill kinase
and promote the production and cloning
of immature B cells that don't do the
work they're supposed to do).
And these antigens could be used
topically as nerve regenerants.
And OspA-mutated B cells could be
pharmed for treatments for diseases
that have mycoplasmal antigens in them
like Pam3Cys/OspA: Tuberculosis, HIV,
Lyme:
http://www.mitre.org/news/digest/advanced_research/11_09/vaccination.html
And Pfizer's New London Infectious
Diseases Division closed up shop after
ruining the homes (Eminent Domain) of
the people in New London, who the likes
of Jodi Rell thought were not entitled
to property that had more value to her
corporate buddies... who happened to
pay no taxes for years (Pfizer), due to
all this New Capital investment,
ROTFLMAO.
OMG, every single frickin evil tard
group in Corrupticut got their gig
boomeranged so far up their bleeps
they make Vlad the Impaler look
like Tinkerbell and her fairy dust.
Ten years fighting the exact same
battle every day... Now Yale wants
to proclaim that they made a discovery
about tick-saliva?
Um, we already heard about it,
in fact from Tom Mather, personally,
in 2000 when I was at the "Diseases
of Summer Conference" at South County
Hospital, heckling Lenny Sigal:
http://www.actionlyme.org/DEBUNKING_THE_CEF_IS_BAD_STUDY.htm
The next year, I was shut out,
so someone else from ActionLyme went with
a tape recorder and captured Mark Klempner
saying this:
http://www.actionlyme.org/ALLFRYT.htm
http://www.youtube.com/watch?v=yPn_T9qy4C0&mode=related&search=
"I found the other MS haplotype
in Lyme, but this is a secret"-- Mark Klempner
LMAO.
Lenny never again gave a presentation
on how Lyme was Fibromyalgia, which
means we're women, and therefore
"catastrophizing," when obviously
the biggest catastrophe happened to
their own OspA gig.
They got NOTHING.
No grants.
No discovery.
KMDickson
http://www.actionlyme.org
========================================
KINGSTON, R.I. -- April 8, 2002 -- When a deer tick bites a human or
other mammalian host, it takes more than 24 hours before the Lyme
disease bacterium travels from the tick’s gut to the tick’s salivary
glands and then into the host. During that time, bioactive proteins in
the tick’s saliva begin to suppress the mammal’s pain response,
increase blood flow to the area, and prevent clotting while at the
same time battling the mammal’s immune system response to the biting
arthropod.
Two University of Rhode Island researchers believe that the proteins
in the tick’s saliva may be the key to developing a new vaccine for
preventing Lyme disease and other tick-transmitted infections by
protecting hosts against blood-feeding ticks. The National Institutes
of Health recently awarded them $2.3 million to screen for the most
promising tick salivary genes over the next five years.
URI entomology Professor Thomas Mather and microbiology Professor
David Nelson, director and associate director, respectively, of the
URI Center for Vector Borne Disease, discovered the importance of tick
saliva as a result of NIH-funded research in the late 1990s. The new
grant will help them pinpoint the genes and proteins that can best be
developed into a vaccine.
"Ticks have more than 400 proteins in their saliva, many of which have
evolved to help them steal blood from a host animal by inactivating
specific factors of the immune system," explained Mather. "We’re
attempting to identify, purify, and learn the function of these
various proteins, because by disrupting their function we may be able
to prevent ticks from feeding and transmitting disease-causing
microbes."
Since they began studying the properties of tick saliva in 1994,
Mather and Nelson, along with collaborators at NIH, have already
identified a significant number of genes that appear promising. More
recently their work has focused on developing a system for rapidly
screening additional gene candidates for those that might be effective
antigens. Mather’s research team makes ticks drool into capillary
tubes by administering a muscle relaxant to the ticks. A precious
commodity, the team has collected more tick saliva than any other
researchers in the world.
"That saliva has become a real treasure chest of potent molecules for
us," Mather said. "It’s now just a matter of sorting them out, which
to me is very exciting."
While Mather focuses on the proteins in the tick saliva, Nelson is
studying the Lyme disease bacterium itself.
"When the bacterium is in the tick’s saliva – on its way from the
tick’s gut to the mammal host’s blood – it’s in a starvation mode
because there aren’t enough nutrients in the tick’s saliva for it to
grow," said Nelson. "We think we’ll be able to find a good vaccine
candidate among the genes expressed in the bacterium’s physiological
response to starvation."
According to Nelson, the Lyme disease bacterium has about 1,000 genes,
but he already knows that some aren’t good candidates for a vaccine.
"To screen all of them isn’t a trivial task. But we can predict which
should be screened, so we’ll probably only need to look at between 75
and 150."
Once Mather and Nelson identify the best vaccine candidates – either
in the tick saliva or in the Lyme disease bacterium – they anticipate
a pharmaceutical company will complete the process of developing it
into a vaccine.
For Information: Thomas Mather 401-874-5616, David Nelson
401-874-5902, Todd McLeish 401-874-7892
"[Real] scientists are *fiercely* independent. That's the good
news."-- NIH's Top Fool, Anthony Fauci