Why Phthalates may be Connected with Cancer and other Negative Outcomes of Phthalate Ingestion

[James Howard]

Why Phthalates may be Connected with Cancer and other Negative Outcomes of
Phthalate Ingestion

It is my hypothesis that low DHEA may trigger breast cancer, as well as
other cancers (Annals of Internal Medicine 2005; 142: 471-472). It is known
that phthalates inhibit sulfotransferase, therefore reducing conversion of
the precursor, DHEAS, to the active molecule, DHEA (Environ Health Perspect.
2007 Dec;115 Suppl 1:51-4). Reducing conversion of DHEAS to DHEA produces
low DHEA. Since I think all tissues rely on sufficient levels of DHEA for
optimal function, I suggest that the negative findings of phthalate
ingestion may result from this reduction converstion of DHEAS to DHEA.

James Michael Howard

Fayetteville, Arkansas, U.S.A.