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Bloodletting For Heart Disease
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ironjustice
May 15, 2012, 8:54:41 AM5/15/12
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The haematocrit - an important factor causing impaired haemostasis in
patients with cyanotic congenital heart disease.
Jensen AS, Johansson PI, Idorn L, Sørensen KE, Thilén U, Nagy E,
Furenäs E, Søndergaard L.
Int J Cardiol. 2012 May 10.
Department of Cardiology, Copenhagen University Hospital,
Rigshospitalet, Copenhagen,Denmark.
Abstract
BACKGROUND: Patients with cyanotic congenital heart disease(CCHD) have
haemostatic abnormalities, which result in an increased risk of
bleeding. The cause is unknown, but recent studies have indicated that
an elevated haematocrit, which is present in cyanotic patients, could
be an important factor. The aim of this study was to characterize the
haemostatic profile, examine how changes in haematocrit affect the
haemostatic profile, and whether a haematocrit reduction could
terminate bleeding in CCHD patients.
METHODS: This was a prospective, multicenter study. The haemostatic
profile consisting of haematocrit, platelet count and
thrombelastography(TEG) was characterized in ninety-eight CCHD
patients. To evaluate the influence of haematocrit on the haemostatic
profile, 21 of the patients underwent phlebotomy and 16 patients
received treatment with an iron supplement. Furthermore ten patients
with haemoptysis underwent phlebotomy. The haemostatic profile was
reevaluated after interventions.
RESULTS: TEG revealed that patients with CCHD and elevated haematocrit
were hypocoagulable due to reduced clot formation and strength.
Furthermore a positive correlation between elevated haematocrit and
hypocoagulability was present. Interventions such as phlebotomy and
treatment with supplemental iron causing significant haematocrit
changes confirmed the correlation between haematocrit and the
haemostatic profile. Finally a haematocrit reduction by phlebotomy
successfully terminated haemoptysis in ten CCHD patients.
CONCLUSION: Patients with CCHD and elevated haematocrit are
hypocoagulable. The hypocoagulable haemostatic profile is positively
correlated to increasing haematocrit. An intervention, which increases
or decreases haematocrit, changes the haemostatic profile. A
haematocrit reduction seems to improve the haemostatic profile, and
may thereby terminate bleeding. However, these results warrant further
studies.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PMID:22578951
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
patients with cyanotic congenital heart disease.
Jensen AS, Johansson PI, Idorn L, Sørensen KE, Thilén U, Nagy E,
Furenäs E, Søndergaard L.
Int J Cardiol. 2012 May 10.
Department of Cardiology, Copenhagen University Hospital,
Rigshospitalet, Copenhagen,Denmark.
Abstract
BACKGROUND: Patients with cyanotic congenital heart disease(CCHD) have
haemostatic abnormalities, which result in an increased risk of
bleeding. The cause is unknown, but recent studies have indicated that
an elevated haematocrit, which is present in cyanotic patients, could
be an important factor. The aim of this study was to characterize the
haemostatic profile, examine how changes in haematocrit affect the
haemostatic profile, and whether a haematocrit reduction could
terminate bleeding in CCHD patients.
METHODS: This was a prospective, multicenter study. The haemostatic
profile consisting of haematocrit, platelet count and
thrombelastography(TEG) was characterized in ninety-eight CCHD
patients. To evaluate the influence of haematocrit on the haemostatic
profile, 21 of the patients underwent phlebotomy and 16 patients
received treatment with an iron supplement. Furthermore ten patients
with haemoptysis underwent phlebotomy. The haemostatic profile was
reevaluated after interventions.
RESULTS: TEG revealed that patients with CCHD and elevated haematocrit
were hypocoagulable due to reduced clot formation and strength.
Furthermore a positive correlation between elevated haematocrit and
hypocoagulability was present. Interventions such as phlebotomy and
treatment with supplemental iron causing significant haematocrit
changes confirmed the correlation between haematocrit and the
haemostatic profile. Finally a haematocrit reduction by phlebotomy
successfully terminated haemoptysis in ten CCHD patients.
CONCLUSION: Patients with CCHD and elevated haematocrit are
hypocoagulable. The hypocoagulable haemostatic profile is positively
correlated to increasing haematocrit. An intervention, which increases
or decreases haematocrit, changes the haemostatic profile. A
haematocrit reduction seems to improve the haemostatic profile, and
may thereby terminate bleeding. However, these results warrant further
studies.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
PMID:22578951
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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