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Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness.

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Immanuel kant

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May 23, 2012, 9:32:52 PM5/23/12
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There has been some renewed interest in psychedelic drugs after the
hysteria of the 60s about their use in psychotherapy and enhancing
creativity. Originally use had been among artists, intellectuals and
scientists. I've more recently found out that Richard Feynman and Carl
Sagan both were hanging out with psychedelic researcher John C. Lilly.
Both admitted marijuana users may have been sampling more potent
things.

J Psychopharmacol. 2011 Nov;25(11):1453-61. Epub 2011 Sep 28.
Mystical experiences occasioned by the hallucinogen psilocybin lead to
increases in the personality domain of openness. MacLean KA, Johnson
MW, Griffiths RR. SourceDepartment of Psychiatry and Behavioral
Sciences, Johns Hopkins University School of Medicine, Baltimore, MD,
USA. katherine...@gmail.com Abstract A large body of evidence,
including longitudinal analyses of personality change, suggests that
core personality traits are predominantly stable after age 30. To our
knowledge, no study has demonstrated changes in personality in healthy
adults after an experimentally manipulated discrete event.
Intriguingly, double-blind controlled studies have shown that the
classic hallucinogen psilocybin occasions personally and spiritually
significant mystical experiences that predict long-term changes in
behaviors, attitudes and values. In the present report we assessed the
effect of psilocybin on changes in the five broad domains of
personality - Neuroticism, Extroversion, Openness, Agreeableness, and
Conscientiousness. Consistent with participant claims of hallucinogen-
occasioned increases in aesthetic appreciation, imagination, and
creativity, we found significant increases in Openness following a
high-dose psilocybin session. In participants who had mystical
experiences during their psilocybin session, Openness remained
significantly higher than baseline more than 1 year after the session.
The findings suggest a specific role for psilocybin and mystical-type
experiences in adult personality change. PMID: 21956378
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