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Testosterone increases ROS
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Taka
May 21, 2013, 4:46:18 AM5/21/13
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"testosterone increased basal reactive oxygen species"
"human PC xenografts growing in male SCID mice supplemented with
testosterone had intense staining for 8-OHdG compared to the same
tumors growing in castrated animals
This staining identifies modified DNA formed by attacks of hydroxyl
radicals"
"Androgens increase bROS levels in an AR-dependent manner. In vivo
effect on human PC xenografts. (A) In vivo expression of oxidative
stress-induced lipid peroxidation as detected by the presence of 4-HNE
protein adducts"
SOURCE: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803036/
Neoplasia. 2007 January; 9(1): 68–80.
Androgen Induces Adaptation to Oxidative Stress in Prostate Cancer:
Implications for Treatment with Radiation Therapy
"human PC xenografts growing in male SCID mice supplemented with
testosterone had intense staining for 8-OHdG compared to the same
tumors growing in castrated animals
This staining identifies modified DNA formed by attacks of hydroxyl
radicals"
"Androgens increase bROS levels in an AR-dependent manner. In vivo
effect on human PC xenografts. (A) In vivo expression of oxidative
stress-induced lipid peroxidation as detected by the presence of 4-HNE
protein adducts"
SOURCE: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803036/
Neoplasia. 2007 January; 9(1): 68–80.
Androgen Induces Adaptation to Oxidative Stress in Prostate Cancer:
Implications for Treatment with Radiation Therapy
John H. Gohde
May 21, 2013, 4:47:23 AM5/21/13
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