Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial.
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Chronic endurance exercise training prevents aging-related cognitive
decline in healthy older adults: a randomized controlled trial.
Muscari A, Giannoni C, Pierpaoli L, Berzigotti A, Maietta P, Foschi E,
Ravaioli C, Poggiopollini G, Bianchi G, Magalotti D, Tentoni C, Zoli
M.
Department of Internal Medicine, Aging and Nephrological Diseases,
University of Bologna, Bologna, Italy.
OBJECTIVE: To evaluate the effects of endurance exercise training
(EET) on the cognitive status of healthy community-dwelling older
adults. METHODS: A randomized controlled trial was conducted involving
community-dwelling older adults from the town of Pianoro (northern
Italy). We randomized 120 healthy subjects aged 65-74 years, both
genders, to treatment (N = 60) and control (N = 60) groups. The
treatment consisted of 12 months of supervised EET in a community gym,
3 h a week. All participants were assessed both at baseline and after
12 months on an intention-to-treat analysis. Cognitive status was
assessed by one single test (Mini Mental State Examination, MMSE).
Anthropometric indexes, routine laboratory measurements and C-reactive
protein (CRP) were also assessed. RESULTS: The control group showed a
significant decrease in MMSE score (mean difference -1.21, 95% CI
-1.83/-0.60, p = 0.0002), which differed significantly (p = 0.02) from
the treatment group scores (-0.21, 95% CI -0.79/0.37, p = 0.47). The
odds ratio for the treated older adults to have a stable cognitive
status after 1 year, as compared to the control group, was 2.74 (95%
CI 1.16/6.48) after adjustment for age, gender, educational level and
several other possible confounders. Blood pressure, body mass index,
waist circumference and serum cholesterol did not differ significantly
between the two groups, while CRP decreased only in the treatment
group. CONCLUSIONS: A 12-month EET intervention may reduce the
progression of age-related cognitive decline in healthy older adults.
Copyright (c) 2009 John Wiley & Sons, Ltd.
PMID: 20033904 [PubMed - as supplied by publisher]
Ted
Thanks for this.