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Boron reduces lipid peroxidation
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Taka
May 24, 2012, 4:22:31 AM5/24/12
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J Trace Elem Med Biol. 2010 Jul;24(3):161-4. Epub 2010 Jan 31.
The effects of dietary boric acid and borax supplementation on lipid
peroxidation, antioxidant activity, and DNA damage in rats.
Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A, Eryavuz A.
Afyon Kocatepe University, Faculty of Veterinary Medicine, Department
of Pharmacology and Toxicology, Afyonkarahisar, Turkey.
The aims of this study were to clarify the effects of high dietary
supplementation with boric acid and borax, called boron (B) compounds,
on lipid peroxidation (LPO), antioxidant activity, some vitamin
levels, and DNA damage in rats. Thirty Sprague Dawley male rats were
divided into three equal groups: the animals in the first group
(control) were fed with a standard rodent diet containing 6.4 mg B/kg,
and the animals in the experimental group were fed with a standard
rodent diet added with a supra-nutritional amount of boric acid and
borax (100 mg B/kg) throughout the experimental period of 28 days. The
B compounds decreased malondialdehyde (MDA), DNA damage, the protein
carbonyl content (PCO) level in blood, and glutathione (GSH)
concentration in the liver, Cu-Zn superoxide dismutase (SOD), and
catalase (CAT) activity in the kidney. The B compounds increased GSH
concentration in blood and the vitamin C level in plasma.
Consequently, our results demonstrate that B supplementation (100 mg/
kg) in diet decreases LPO, and enhances the antioxidant defense
mechanism and vitamin status. There are no differences in oxidant/
antioxidant balance and biochemical parameters except for serum
vitamin A and liver GSH concentration, between the boron compounds
used in this study.
PMID: 20569927
The effects of dietary boric acid and borax supplementation on lipid
peroxidation, antioxidant activity, and DNA damage in rats.
Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A, Eryavuz A.
Afyon Kocatepe University, Faculty of Veterinary Medicine, Department
of Pharmacology and Toxicology, Afyonkarahisar, Turkey.
The aims of this study were to clarify the effects of high dietary
supplementation with boric acid and borax, called boron (B) compounds,
on lipid peroxidation (LPO), antioxidant activity, some vitamin
levels, and DNA damage in rats. Thirty Sprague Dawley male rats were
divided into three equal groups: the animals in the first group
(control) were fed with a standard rodent diet containing 6.4 mg B/kg,
and the animals in the experimental group were fed with a standard
rodent diet added with a supra-nutritional amount of boric acid and
borax (100 mg B/kg) throughout the experimental period of 28 days. The
B compounds decreased malondialdehyde (MDA), DNA damage, the protein
carbonyl content (PCO) level in blood, and glutathione (GSH)
concentration in the liver, Cu-Zn superoxide dismutase (SOD), and
catalase (CAT) activity in the kidney. The B compounds increased GSH
concentration in blood and the vitamin C level in plasma.
Consequently, our results demonstrate that B supplementation (100 mg/
kg) in diet decreases LPO, and enhances the antioxidant defense
mechanism and vitamin status. There are no differences in oxidant/
antioxidant balance and biochemical parameters except for serum
vitamin A and liver GSH concentration, between the boron compounds
used in this study.
PMID: 20569927
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