A justification for ironjustice from Longevinex
Taka
A lot of health news stories get jumbled around. A recent one says
“Proper sleep may help clear arteries.” (Health Day, Dec. 23, 2008)
The news story emanates from a study published in the Dec. 31, 2008
issue of the Journal of the American Medical Association (Journal Am
Medical Assn 2008; 300 (24):2859-2866)
The idea sounds good. Get a good night’s sleep and your stiff,
calcified arteries will become elastic once again. But there is only
an association between sleep duration and less arterial
calcification. A doctor involved in this recent study said “Until we
know why, we can’t tell whether it is a causal association.”
The study involved 495 participants, ages 35 to 47, with the incidence
of artery calcification, measured by CT scans. None of the
participants had detectable calcium deposits when the study began, but
five years later, 61 (12.3 percent) did. The researchers found that
one more hour of sleep a night decreased the risk of calcification by
a third. That's about as much as a 16.5-point reduction in blood
pressure.
A more plausible link between sleep and arterial calcification is the
progressive calcification of the pineal gland with advancing age.
This is the gland at the base of the brain that produces the sleep
hormone called melatonin at night. Once in darkness or upon eye
closure, the pineal gland begins to secrete melatonin, usually on a
cycled rhythm that has already been established.
Humans generally sleep well during the childhood growth years, before
the pineal gland has become calcified. But once childhood growth
ceases and dietary calcium is no longer being shuttled to make new
bone, excess calcium begins to build up in cells and organs like the
pineal gland.
A report in the August 2008 issue of Sleep Medicine explains that
calcification of the pineal gland is linked with a shortage of
melatonin and insomnia. (Sleep Medicine August 27, 2008 online)
As early as 1993 a report linked pineal gland calcifications and
decreased melatonin production. (Gerontology 1993; 39 (4): 189-99)
A primary symptom of the lack of melatonin due to a calcified pineal
gland is daytime sleepiness. (Psychiatry Research 1998 June 30; 82
(3) 187-91)
While supplemental melatonin has been proposed to resolve age-related
insomnia, the de-calcification of the pineal gland would be a more
appropriate approach.
The use of an oral calcium chelator (agent that removes
calcifications) has been shown to improve melatonin secretion from the
pineal gland. (Neuroscience Letters 1998 April 10; 245(3):143-6)
Iron overload is also associated with a decline in melatonin secretion
from the pineal gland. (Psychoneuroendocrinology 1983; 8(3):321-6)
Dietary copper may also impair synthesis of melatonin. (Comparative
Biochemistry Physiology A Molecular Integrated Physiology 2003 May; 135
(1):25-38)
The progressive calcification of the pineal gland was first proposed
as a biological clock for aging in 1990, given that life expectancy
curves are linked with calcification of the pineal gland.
(Gerontology 1990; 36 (5-6) 314-22)
Longevinex®, with its provision of a major oral calcium chelator (rice
bran IP6) and the fact that it provides an iron chelator (quercetin)
and a copper chelator (resveratrol), may explain the many case reports
of longer, more restful sleep when taking Longevinex®.
Kofi
> bran IP6)
IP6 (inositol hexaphosphate/phytic acid) also inhibits magnesium and
zinc absorption. NOT good for longevity.
Anybody know of a decent calcium chelator?
I suspect butyrate plays a role in limiting the body's calcium intake
since it would sensitize heart muscle to calcium signals. There's
probably a feedback loop somewhere to help "normalize" calcium levels in
response.
> and the fact that it provides an iron chelator (quercetin)
> and a copper chelator (resveratrol)
Weren't you the one with joint problems on resveratrol?
Marshall Price
>> LongevinexŽ, with its provision of a major oral calcium chelator (rice
For *every* problem, I just keep thinking, "I'm glad that's not my
problem"! :)
What a joy, counting my blessings, one by one!
--
Marshall Price of Miami
d021...@fastmail.fm
http://marshallprice.wordpress.com/
Taka
> > and the fact that it provides an iron chelator (quercetin)
> > and a copper chelator (resveratrol)
>
> Weren't you the one with joint problems on resveratrol?
Yes, I was. Not the first one though ... The Longevinex site has
been revamped now selling the 3rd generation of Sardi's supplement
which they claim has no side effects on "collagen breakdown". Have a
look, the video there strongly pushes the overmineralization theory of
aging, could aging be this simple?
I also got a message from Bill Sardi urging me to remove my post from
AOL because it redirects traffic away from his site and he never gave
permission for it to be posted elsewhere. Sorry, I never
intentionally posted it to AOL and don't know how to remove it from
there. I also thought that messages which are spamming my mailbox
were copyright free ... And if he is right with the
overmineralization theory of aging, then he should pay credit to Tom/
ironjustice because he is the one who has been propagating IP6 and
iron removal here for years.
Taka
rj...@my-deja.com
Was it joint problems you had, or was it tendons and ligament? The
collagen/resveratrol issue seems unlikely to be due to copper
chelation, the effect is minute if it exists in vivo. It is possible
that the anti-angiogenesis effect of resveratrol can cause ligament or
tendon issues; those tissues are so poorly supplied with blood a
reduction of angiogenesis could delay or prevent healing, and a series
of micro-tears or other injuries would compound the situaton.
Quercetin has a similar effect on agiogenesis.
The over-mineralization theory of aging is unlikely IMO to be correct
as to cause. Treating symptoms can sometimes be helpful, but IP6 is
likely to have undesired effects particularly for women. If you are
prone to Hemachromatosis it might be helpful.
Taka
> Was it joint problems you had, or was it tendons and ligament?
Mostly ligament with degenerating cartilage (ACL, meniscus,
osteoarthritis 20 years earlier ...).
> The
> collagen/resveratrol issue seems unlikely to be due to copper
> chelation, the effect is minute if it exists in vivo. It is possible
> that the anti-angiogenesis effect of resveratrol can cause ligament or
> tendon issues; those tissues are so poorly supplied with blood a
> reduction of angiogenesis could delay or prevent healing, and a series
> of micro-tears or other injuries would compound the situaton.
> Quercetin has a similar effect on agiogenesis.
Quercetin was in the supplement I was taking too. Looking
retrospectively back I guess it was the COX-1,2 inhibitory action of
both resveratrol and fish/flax oils I was taking at that time which
impended my healing capacity (while being on an already high Omega-3
Japanese diet).
> The over-mineralization theory of aging is unlikely IMO to be correct
> as to cause. Treating symptoms can sometimes be helpful, but IP6 is
> likely to have undesired effects particularly for women. If you are
> prone to Hemachromatosis it might be helpful.
Sounds fishy to me too that the evolution would design such a dumb
"machine" which would keep accumulating the minerals after the growth
ceased at the same speed as during the fast growth years. He also
gives the example of the mole rat breeding queen who has the highest
longevity because of constant shredding of minerals into her puppies.
But I have seen an article that it were the sleepers waiting to
replace the queen when she dies who had the highest longevity and
negligible aging. He would probably also suggest that the turtles
live 200 years because they are disposing of the excess minerals into
their shells ...
Taka
anon...@nowhere.you.know
"machine" which would keep accumulating the minerals after the growth
ceased at the same speed as during the fast growth years. He also"
But the correction is at the other end. Humans have a feed back path
for control of iron uptake and sequestration of free iron.