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Epigenetic transgenerational inheritance of altered stress responses
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John H. Gohde
May 24, 2012, 7:32:57 PM5/24/12
to
Epigenetic transgenerational inheritance of altered stress responses
Article
http://tinyurl.com/cn9wt58
Research Study in Full PDF
http://tinyurl.com/cvbqnb4
Short Video
http://tinyurl.com/bn738dl
Long Video
http://tinyurl.com/bu37klq
Article
http://tinyurl.com/cn9wt58
Research Study in Full PDF
http://tinyurl.com/cvbqnb4
Short Video
http://tinyurl.com/bn738dl
Long Video
http://tinyurl.com/bu37klq
John H. Gohde
May 27, 2012, 3:56:14 AM5/27/12
to
The most revolutionary research study to be published in at least the
last ten years. The very first proof of principle experiment,
empirical demonstration of cause and effect that conclusively
demonstrates that environmental exposures ARE inherited by ALL
subsequent generations.
Was Lamarck genetics correct?
Are the obesity and autism epidemics the result of epigenetic
transgenerational inheritance?
Epigenetic transgenerational inheritance of altered stress responses
Abstract
Ancestral environmental exposures have previously been shown to
promote epigenetic transgenerational inheritance and influence all
aspects of an individual's life history. In addition, proximate life
events such as chronic stress have documented effects on the
development of physiological, neural, and behavioral phenotypes in
adulthood. We used a systems biology approach to investigate in male
rats the interaction of the ancestral modifications carried
transgenerationally in the germ line and the proximate modifications
involving chronic restraint stress during adolescence. We find that a
single exposure to a common-use fungicide (vinclozolin) three
generations removed alters the physiology, behavior, metabolic
activity, and transcriptome in discrete brain nuclei in descendant
males, causing them to respond differently to chronic restraint
stress. This alteration of baseline brain development promotes a
change in neural genomic activity that correlates with changes in
physiology and behavior, revealing the interaction of genetics,
environment, and epigenetic transgenerational inheritance in the
shaping of the adult phenotype. This is an important demonstration in
an animal that ancestral exposure to an environmental compound
modifies how descendants of these progenitor individuals perceive and
respond to a stress challenge experienced during their own life
history.
http://www.ncbi.nlm.nih.gov/pubmed/22615374
Article ON Epigenetic transgenerational inheritance of altered stress
responses
http://tinyurl.com/cn9wt58
Short Video interview with research author Michael Skinner. The
interview eventually gets into the implications of this research. Or,
how environment exposures can impact environmental epigenetics and
disease susceptibility in generations to come. A lead researcher in
the field OF Transgenerational epigenetics who gave this talk, 6
months before the current study was published.
http://tinyurl.com/bn738dl
Long Video interview with lead author David Crews that gets into the
implications of this research.
http://tinyurl.com/87n4ban
last ten years. The very first proof of principle experiment,
empirical demonstration of cause and effect that conclusively
demonstrates that environmental exposures ARE inherited by ALL
subsequent generations.
Was Lamarck genetics correct?
Are the obesity and autism epidemics the result of epigenetic
transgenerational inheritance?
Epigenetic transgenerational inheritance of altered stress responses
Ancestral environmental exposures have previously been shown to
promote epigenetic transgenerational inheritance and influence all
aspects of an individual's life history. In addition, proximate life
events such as chronic stress have documented effects on the
development of physiological, neural, and behavioral phenotypes in
adulthood. We used a systems biology approach to investigate in male
rats the interaction of the ancestral modifications carried
transgenerationally in the germ line and the proximate modifications
involving chronic restraint stress during adolescence. We find that a
single exposure to a common-use fungicide (vinclozolin) three
generations removed alters the physiology, behavior, metabolic
activity, and transcriptome in discrete brain nuclei in descendant
males, causing them to respond differently to chronic restraint
stress. This alteration of baseline brain development promotes a
change in neural genomic activity that correlates with changes in
physiology and behavior, revealing the interaction of genetics,
environment, and epigenetic transgenerational inheritance in the
shaping of the adult phenotype. This is an important demonstration in
an animal that ancestral exposure to an environmental compound
modifies how descendants of these progenitor individuals perceive and
respond to a stress challenge experienced during their own life
history.
http://www.ncbi.nlm.nih.gov/pubmed/22615374
Article ON Epigenetic transgenerational inheritance of altered stress
responses
http://tinyurl.com/cn9wt58
Short Video interview with research author Michael Skinner. The
interview eventually gets into the implications of this research. Or,
how environment exposures can impact environmental epigenetics and
disease susceptibility in generations to come. A lead researcher in
the field OF Transgenerational epigenetics who gave this talk, 6
months before the current study was published.
http://tinyurl.com/bn738dl
Long Video interview with lead author David Crews that gets into the
implications of this research.
http://tinyurl.com/87n4ban
"pill popper"
May 28, 2012, 10:00:37 AM5/28/12
to
"The most revolutionary research study to be published in at least the last
ten years. The very first proof of principle experiment, empirical
demonstration of cause and effect that conclusively demonstrates that
environmental exposures ARE inherited by ALL subsequent generations."
study to observe such change which usually drops out after a generation or
two.
"Was Lamarck genetics correct?"
No, his claim was for the origin of new species. His idea was overtaken by
darwin.
"Are the obesity and autism epidemics the result of epigenetic"
Part of the obesity response seems to be a genetic response to large swings
in food supply. During good times fat stores build up while they are used
to get through the poor times. The epigenetic part comes in when the hard
times switches the store fat genes on. The change drops out in the next
generation or so if times improve.
John H. Gohde
May 28, 2012, 6:09:48 PM5/28/12
to
It is NOT me talking, but the lead author himself, David Crews. Five
generations to date for animals, and 200 genrations for plants with no
drop off.
Again, all you have to do is listen to the entire interviews.
Premiere researcher Michael Skinner, also, has a lot say.
Morons like you are just A-holes. :)
"pill popper"
May 28, 2012, 7:37:50 PM5/28/12
to
"WRONG on all counts, of course. :)
It is NOT me talking, but the lead author himself, David Crews. Five
generations to date for animals, and 200 genrations for plants with no"
The abstract you provided said 3 only. I did not listen to the links.
It is NOT me talking, but the lead author himself, David Crews. Five
generations to date for animals, and 200 genrations for plants with no"
Plants seem hardly relevant to mammals.
Do tell us, in how many animal species do the epigenetic on and off states
persist?
John H. Gohde
May 28, 2012, 8:11:44 PM5/28/12
to
say about their own research study. Only a SCIENCE MORON, like
yourself, would be arrogant to say otherwise.
I gladly defer to the experts in the field of epigenetics, and will
ignore the babblings of educated SCIENCE morons. :)
You are just an obsolete fossil. :)
"pill popper"
May 28, 2012, 8:41:34 PM5/28/12
to
> "WRONG on all counts, of course. =A0:)
>
> It is NOT me talking, but the lead author himself, David Crews. =A0Five
"I gladly defer to the experts in the field of epigenetics, and will ignore
the babblings of educated SCIENCE morons. :)"
Then it should be no problem to tell us how many switched on or off genes
persist for how many generations on average in how many species.
"You are just an obsolete fossil. :)"
Smile, I was reading about epigenetics and commenting on it for more then
10 years, since the beginning. You have only recently started to make
comment.
So we "fossles: have a thing or two to teach the new kids on the block.
>
> It is NOT me talking, but the lead author himself, David Crews. =A0Five
> generations to date for animals, and 200 genrations for plants with no"
>
> The abstract you provided said 3 only. =A0I did not listen to the links.
>
> Plants seem hardly relevant to mammals.
>
> Do tell us, in how many animal species do the epigenetic on and off
state=
>
> Do tell us, in how many animal species do the epigenetic on and off
s
> persist?
"I pay a great deal of attention to what the key researchers have to say
about their own research study. Only a SCIENCE MORON, like yourself, would
be arrogant to say otherwise."
The abstract you used said 3 only. Pay attention to what you post.
> persist?
"I pay a great deal of attention to what the key researchers have to say
about their own research study. Only a SCIENCE MORON, like yourself, would
be arrogant to say otherwise."
"I gladly defer to the experts in the field of epigenetics, and will ignore
the babblings of educated SCIENCE morons. :)"
persist for how many generations on average in how many species.
"You are just an obsolete fossil. :)"
10 years, since the beginning. You have only recently started to make
comment.
So we "fossles: have a thing or two to teach the new kids on the block.
John H. Gohde
May 28, 2012, 8:47:16 PM5/28/12
to
published.
Until I get a list of studies that you were personally involved in, I
shall defer to the premier epigenetic researchers David Crews and
Michael Skinner.
Unlike you, both of them with their video interviews have put their
butts on the line. :)
"pill popper"
May 29, 2012, 10:16:26 AM5/29/12
to
> Then it should be no problem to tell us how many switched on or off genes
> persist for how many generations on average in how many species.
>
> "You are just an obsolete fossil. =A0:)"
> persist for how many generations on average in how many species.
>
>
> Smile, I was reading about epigenetics and commenting on it for more then
> 10 years, since the beginning. =A0You have only recently started to make
> Smile, I was reading about epigenetics and commenting on it for more then
> comment.
>
> So we "fossles: have a thing or two to teach the new kids on the block.
"Kindly, identified the epigenetic studies that you personally published."
Read it again, no claim of original research on my part. I have followed
>
> So we "fossles: have a thing or two to teach the new kids on the block.
"Kindly, identified the epigenetic studies that you personally published."
the literature closely because of my interest in evolutionary theory.
"Until I get a list of studies that you were personally involved in, I
shall defer to the premier epigenetic researchers David Crews and Michael
Skinner."
lasts but a few generations, you are blowing hot air.
Appeals to authority is among the least relevant kinds of evidence.
Now don't go trying that science stuff on us again.
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