DHT increases XMRV replication rate threefold

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Dec 20, 2009, 12:27:36 PM12/20/09
Androgen Stimulates Transcription and Replication of XMRV (Xenotropic
Murine Leukemia Virus-Related Virus).
Dong B, Silverman RH.

Department of Cancer Biology, Lerner Research Institute, Cleveland
Clinic, 9500 Euclid Avenue, Cleveland, OH 44195.

XMRV is a gammaretrovirus originally identified in a subset of
prostate cancer patients. Because androgens stimulate prostate tumors
and some retroviruses, we investigated effects of dihydrotestosterone
(DHT) on XMRV transcription and replication. Transcription from the
XMRV U3 region was stimulated up to 2-fold by DHT, but only in cells
containing a functional androgen receptor. Mutations in the
glucocorticoid response element (GRE) of XMRV impaired basal
transcription and androgen responsiveness. Furthermore, DHT stimulated
XMRV replication by 3-fold, whereas androgen inhibitors (casodex and
flutamide) suppressed viral growth up to 3-fold. Findings suggest that
integration of the XMRV LTR into host DNA could impart androgen
stimulation on cellular genes.

PMID: 19906923 [PubMed - as supplied by publisher]

I guess I get some propecia now.

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