Roxithromycin for hair growth and anti-greying effects

[Kofi]

I think rapamycin is also in this class of antibiotics

http://www.hairsite4.com/dc/dcboard.php?az=show_topic&forum=8&topic_id=35
358&mode=full

#35358, "Topical Roxithromycin"
Tue Jul-18-06 12:15 PM by Hogan38

Here is some information for a new topical application of Roxithromycin.
Appparently the mechanism in which Roxithromycin works is that it
inhibits T cell responces to mitogens and production of cytokines, IL-2
and IL-5 (nothing to do with DHT). You can now purchase it Lipoxidil (
http://www.lipoxidil.com/site/experimental.php ).

However since BoratS says that inflammation is not the SOLE PROXIMATE
CAUSE of hair loss, you may want to stay away from it, since he would
know better than these scientists and doctors.

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ProduktN
r=224164&Ausgabe=231841&ArtikelNr=92842&filename=92842.pdf

Hair Restoration and Anti-Gray Hair Effects
by Topical Roxithromycin
T. Ito, N. Ito, N. Seo, H. Yagi, H. Hashizume
Masahiro Takigawa Dermatology, Hamamatsu University
School of Medicine, Hamamatsu, Japan

There are still few effective topical substances for androgenetic
alopecia (AGA). In this study, we found that roxithromycin (RXM) has
anti-apoptotic and anti-gray hair effects on AGA in vitro, and indeed,
clinically improved or prevented hair loss of AGA. RXM is a 14-member
new macrolide antibiotic and has been extensively used for prevention
and treatment of systemic and local infection. In addition, recent
studies revealed RXM also has various modulatory bioactivities of many
kinds of cells, such as Langerhans cells, keratinocytes and T cells.
Human hair follicles, obtained from plastic surgery with informed
consent, were cultured for 6 days. In the control group, hair elongation
was 1.96 0.19 mm. On the other hand, it was 3.4 0.20 mm and 3.32 0.19
mm in 5 M RXM and 10 M RXM treated group, respectively in vitro. The
groups treated with 5 M CLM (2.17 0.13 mm), 10 M (1.93 0.18 mm), 5 M EM
(2.85 0.13 mm), 10 M EM (2.05 0.19 mm) showed no significant hair
elongation compared with the control group. Next, 11 male individuals
suffering from AGA topically applied 8 ml RXM at 0.5% in alcoholic
solution once a day for 6 months with informed consent. Photographs were
then scored, 4 patients apparently showed improvement of hair
restoration, 4 patients were more than slight improvement, and 3
patients were no improvement. Topical RXM used under these conditions
was safe without any local and systemic adverse effects. The beneficial
effects of RXM seem to result from prevention of apoptosis of matrix
cells and melanocytes in human hair follicles. RXM is a promising
candidate for effective and safe treatment of AGA.

Here is a clinical trial held in Japan for the application of it.

http://www.clinicaltrials.gov/ct/show/NCT00197379

Further study details as provided by Hamamatsu University:
Primary Outcomes: The hair elongation after 1 week of application.
Cosmetical improvement. Evaluation by dermoscopy
Secondary Outcomes: Pathological study taken from lesional scalp skin.
Expected Total Enrollment: 20
Study start: May 2005; Expected completion: June 2007
Last follow-up: January 2007; Data entry closure: March 2007

The topical therapy for androgenetic alopecia is still not enough to
improve cosmetically. Thereforem we try to find new effective and safe
topical therapy for this disease. Roxithromycin has not only
antibacterial action but also immunomodulatory and anti-inflamatory
potency. For example, roxitromycin inhibits T cell responces to mitogens
and production of cytokines, IL-2 and IL-5. We firstly found that
roxitromycin increased human and murine hair elongation in vitro to
inhibit apoptosis of hair bulb. Then, we wish to apply roxithromycin on
the therapy for androgenetic alopecia.

[ch...@my-deja.com]

Kofi wrote:

>
> However since BoratS says that inflammation is not the SOLE PROXIMATE
> CAUSE of hair loss, you may want to stay away from it, since he would
> know better than these scientists and doctors.
>

Inflammation may be a factor when using other anti-aging stuff.

As I, and others, have speculated/ranted here before, "the Fountain of
Youth" R-ALA/ALC may be causing hairloss thru some inflammatory pathway
(if it's not an increase in T or a drop in biotin).

Likewise, I've been feeling great lately taking an icy acai smoothie
each morning. But I noticed hair in the shower drain for the first time
since using caffeine shampoo!

Then, googling on Hair and Acai, I find one posting about suspected
increased hairloss using acai in yogurt. (could it be from the reputed
hormonal increase? Treating "hairloss" is in the long list of
"traditional uses" found at acai hype sites).

DAMN...it seems you have to choose between increased drive , youthful
energy and libido - OR keeping simply your hair and prostate in their
place...:-)

[Chuck]

I have always lost hair in cycles so I think it would be really hard to
say if something like this was the cause. I take Proscar, so a little
rise in T does not concern me personally. Actually, Proscar raises T
somewhat.