absorbsion of O2 into muscles

[john Yafmen]

Anyone know of any info on maximizing Oxygen absorbsion in the
muscles. I have an old Life Extensions book but it's probably out of
date. My friend is loosing muscle strength because of a childhood
case of Polio.

thanks,
John

[Fred Thomas]

john Yafmen <yaf...@altavista.net> wrote in message
news:4d867e5c.01073...@posting.google.com...

PubMed Identifier
9266539
Authors
Mizuno M. Quistorff B. Theorell H. Theorell M. Chance B.
Institution
Department of Medical Biochemistry and Genetics, Panum Institute, University
of Copenhagen, Denmark.
Title
Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal
muscle energy metabolism in middle-aged post-polio subjects and normal
volunteers.
Source
Molecular Aspects of Medicine. 18 Suppl:S291-8, 1997.
Abstract
The effects of oral supplementation of 100 mg coenzyme Q10 (CoQ10) for 6
months on muscle energy metabolism during exercise and recovery were
evaluated in middle-aged post-polio (n = 3) and healthy subjects (n = 4) by
the use of phosphorus-31 nuclear magnetic resonance spectroscopy. The
metabolic response to isometric plantar flexion at 60% of maximal voluntary
contraction force (MVC) for 1.5 min was determined in gastrocnemius muscles
before, after 3- (3MO) and 6-month (6MO) of CoQ10 supplementation. The MVC
of plantar flexion was unchanged following CoQ10 supplementation. The
resting Pi/PCr ratio in gastrocnemius muscles of all subjects decreased
after 3MO- and 6MO-CoQ10 (P < 0.05). The post-polio individuals showed a
progressive decrease in this ratio, while less pronounced changes were
observed in the control subjects. Similarly, the post-polio individuals
showed a lower Pi/PCr ratio at the end of 60% MVC in both 3MO- and
6MO-CoQ10, whereas no change in the ratio was observed in the control
subjects. A less pronounced decrease in muscle pH was observed at the end of
60% MVC in both 3MO- and 6MO-CoQ10 in the post-polio individuals, but not in
the control subjects. No systematic difference in end-exercise ATP was
observed between the three phases in both groups. The half-time of recovery
for PCr decreased in all subjects after 6MO-CoQ10 supplementation (P <
0.05). The results suggest that CoQ10 supplementation affects muscle energy
metabolism in post-polio individuals to a greater extent than in control
subjects. The mechanism for this effect is not clear, but may involve an
effect of CoQ10 on peripheral circulation in the calf muscles, its action in
mitochondrial oxidative phosphorylation and/or its antioxidant potential.

[john Yafmen]

Fred,

Thanks much for the article. It wasn't completely clear to me what
the result is since it says ultimately that "The results suggest that

CoQ10 supplementation affects muscle energy metabolism in post-polio

individuals to a greater extent than in control subjects". But I'm
going to assume that the "affect" is positive. So, what is CoQ10 and
where can my friend get it?

thanks,
John

"Fred Thomas" <fr...@stellartron.com> wrote in message news:<EEF97.141485$Tx5.1...@e420r-chi1.usenetserver.com>...