COVID Ventilator Design Hackathon, esp third world

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vjp...@at.biostrategist.dot.dot.com

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Mar 26, 2020, 7:10:57 PM3/26/20
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First of all, the design has to be extremely simple and robust so anyone
can manufacture or repair it. Think easy to fix Lada vs better Traband, or
the development economist calling for "appropriate technology". Time cannot
be wasted waiting for a specialist. Also see HBR article ca 1987 about the
IBM Chapel Hill the printer design being simplified for robot so it became
easier to make by hand.

Off pump CABG and asceptic milk came about because power is not relaible
in most of the world. Plus in emergency, power may not be reliable even
here. So diesel seems preferable but a room full of MASH diesel repsirators
would kill faster than COVID. So I'm thinking you have to generate motion
(pneumatically, mechanically) outside the building and transmit it
inside. Also it should be at the opposite end of the building from oxygen
concentrators or electrolytic generators, for smoke and fire reasons. One
idea was a pump, with a big bellows, like induction, powering smaller
bellows. Practitioners seem to prefer pistons. The other would be like a car
transmittion shaft running through the building. Manhattan and other old
industrial cities still have public steam power. Design specs: Cooney 1976
v2 p347,413, 12 breath/min, 284 ml/min O2 104 mm Hg, 227 ml/min CO2 40 mm Hg.
You would been to adjust volume flow and pulse rate by patient, and you need
some random sigh to assure the lungs work right (Bronzino ch 11). In the
bellows case, ie pneumatic control, I thought maybe to convolute the pipes
into some turbulence for sighs, which might however release projectives,
blocked by the inductive discontinuity. Mechanical control might also be
amendable to mechanical tuning. Maybe the pumps should only move the lungs
and keep them inflated, and to be sure, better to do the gas exchange through
the blood via canula like dialysis. Or a perfluorocarbon artificial blood
though a gut catheter. I cringe at the thought of some third world kid
having to manually pump his granma's lungs but also wonder why it wasn't done
in China and Italy to those who were triaged against respirators because of
supply. If this goes to the third world manual ventilators need to be
considered. Musk might well provide wonderful batteries but when I was a teen
my uncle-in-law was responsible for the batteries of Greek subs and had
nightmares of them exploding (All stored energy, carbon, electrical, nuclear
explodes); of course, they too, might be kept at a distance from patients.

Exacerbating pre-existing medical conditions should also be treated
pharmacologically to minimise respirator time. I was blown away a few weeks
ago at grand rounds that they use colchicine to reduce heart compression from
TB. I've used it for gout and it is brutal, but it really works. Maybe it can
reduce lung inflamation. Fibrotic lungs could be treated with relaxin, a
pregnancy antifibrotic hormone which, however, could cause aneurisms.
Further, asma could be treated by rapamycin analogs (DL001 and SAR943).


https://en.wikipedia.org/wiki/Medical_ventilator
https://accessmedicine.mhmedical.com/content.aspx?bookid=520&sectionid=41692239%20
https://hackaday.com/2020/03/12/ultimate-medical-hackathon-how-fast-can-we-design-and-deploy-an-open-source-ventilator/



- = -
Vasos Panagiotopoulos, Columbia'81+, Reagan, Mozart, Pindus
blog: panix.com/~vjp2/ruminatn.htm - = - web: panix.com/~vjp2/vasos.htm
facebook.com/vasjpan2 - linkedin.com/in/vasjpan02 - biostrategist.com
---{Nothing herein constitutes advice. Everything fully disclaimed.}---












- = -
Vasos Panagiotopoulos, Columbia'81+, Reagan, Mozart, Pindus
blog: panix.com/~vjp2/ruminatn.htm - = - web: panix.com/~vjp2/vasos.htm
facebook.com/vasjpan2 - linkedin.com/in/vasjpan02 - biostrategist.com
---{Nothing herein constitutes advice. Everything fully disclaimed.}---




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