I think 90DA nd 10HDA could be engineered to be mass produced at yeast

1 view
Skip to first unread message

Treon Verdery

unread,
Oct 4, 2022, 4:05:21 AMOct 4
to
Chemical molecular entertainment: Is it possible to make a pleasant nootropic, or a highly effective nootropic into a longevity drug; phenibut could have a c=c on it, and a distal =O and a -O, but it might not pass the blood brain barrier, it would still have the distal phenyl on it though (entertainment, not an actual product), phenylethylamine, which causes me to write up to 44 pages of notes on new ideas during about 24-48 hours could have some more alkane C-C happening after the N, and at the further distal alkane could have the =O and -O at a decanoic (10 C) acid, it might do anything, it might be a stimulating nootropic that at 10HDA 60-600mg doses caused mammals like mice to live double digit percentages 25(27%)longer, or even the 46% greater longevity at c elegans





Notably, at previous notes grinding up termite queens (half century longevity) and feeding them to mice, with an enteric coating on the ground up termite material, as well as findout if c elegans lived longer with termite hemolymph at their food or medium was described as a possible longevity drug finding area, termite queens make 90DA, a royal jelly function like chemical







10HDA numbers: “A main component of royal jelly is 10HDA, which can compose 2–6% of royal jelly; this translates into a 100–300mM concentration in royal jelly.”, that also suggests, as the ratio of a published sample of royal jelly was about 3 parts 10 H2DA to 1 part 10 HDA that royal jelly could actually be 18% 10 H2DA, or 24% all 10DHAlike lipids, although that 1/4 lipids thing seems different than the way lyohilized royal jelly looks;

the paper where 10DHA is a thing that turns a methylated gene back on is able to do that with a similar, but different system, at 5mM, and that royal jelly is 100-300 mM, that suggests the plausability that getting 10HDA to the largest variety of tissues could provide a longevity benefit that complements and enhances getting an equivalent to mouse longevity dose amount of 10HDA (or also royalactin), that suggests three sizes of liposomes, and three different phosphatidyl compositions of liposomes, as well as variety at physioavailability enhancers like piperine and quercetin simultneously





surveying libraries is beneficial, they might even find new disease treatments as well,



Noting the screen all FDA drugs to find longevity drugs screening a library approach, numerous dna on the histone activity drugs like HDACs as well as HDIs as well as (possibly) HATS are anti-cancer drugs, screening all FDA anti-cancer drugs as well as HDIs to find new longevity drugs, noting that I just noticed FDA anti-cancer drugs also contain chromatin-access drugs, this could find new longevity drugs. Online it says that HDIs increase longevity at organisms, suggesting mouse screening of all FDA HDI, HDAC, HAT other chromatin accessibility acvtive drugs is a longevity drug finding activity



It is likely a more effective HDI that is a peptide is possible, a paper says, “cyclic peptides are the most structurally complex group of HDAC inhibitors and include depsipeptide, apicidin, and the cyclic hydroxamic acid-containing peptide group of molecules”



10HDA as an autophagy longevity drug: 10 HDA might cause more autophagy, a thing they could see if it happens, (at the study where 10HDA makes the daf 2 mutants live 46% longer) “10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling.” I perceive calorie restriction longevity effects heighten autophagy and protein recycling, so localization of 10HDA forms might cause some kind of tissue youthification if 10HDA causes greater autophagy, so cardioarea as well as vascular heightened autophagy might go with reducing heart disease, I read autophagy at neurons is beneficial, “Upregulation of this pathway may be neuroprotective, and much effort is being invested in developing drugs that cross the blood brain barrier and increase neuronal autophagy.” so a 10HDA variation that passes the blood brain barrier even more than 10DHA could be a beneficial drug, perhaps the threonate amino acid at Mg threonate could do it, or, at a few amu molecule acetylation (passes blood brain barrier) of 10HDA versions could be measured as to beneficial effects on mouse longevity and congitive youthfulness; an acetyl group on the 120HDA that causes it to pass the blood brain barrier a bunch more could be chemically obvious if you asked a chemist, to make, and maintain the few-AMU size of the molecule, a halogen (p-cholophenoxy moiety) might do it as well,



A liposomal pharmaceutical is about 4 times as physiologically available because it omits first pass heaptic metabolism from going directly to the lymphatic compartment, it could be that liposomal 10HDA has 4 times greater effect at a mg/dose; 10HDA is on alibaba, as is royal jelly, so comparatively big amounts of liposomal royal jelly, or a few tens or hundreds of mg of liposomal just 10HDA could be more effective longevity drugs (mice 25(27%), c elegans 18-46%); also it is possible that liposomes reach different tissues compared with oral royal jelly, royal jelly at enteric capsules, as well as pure 10HDA which is alibabaish, Also, even though a person making juice only gets some juice and some wet unpressed mass, a solvent extraction of royal jelly, which I could ask a chemist on fiverr about, would leave a pressed mass that I could still eat for 10HDA as well as royal jelly benefits if the solvent is edible; thinking about the places liposomal 10 HDA or even liposomal royal jelly could travel to, one online thing mentioned that liposomes might not always be beneficial to the tissues they visit, that brings up the possibility of making liposomes from completely brain beneficial phospholipids, I perceive phosphatidylserine “Phosphatidylserine (PS) is a phospholipid component of the membrane encasing every one of your brain cells”, is a beneficial nootropic, so even though the 10DHA liposomes could travel the entire body, if a quantity of them made it past the blood brain barrier they would be made of a brain-beneficial phospholipid phosphatidylserine chemical; DHA phosphatidylserine EPA together cause greater cheerfulness



Dimethylaminoethanol is a nootropic, another phosphatidyl thing that might make liposomes is phosphatidylethanolamine; this is another phosphitidyl chemical that is, at a nonhuman brain, 45.9% of the phospholipids at the hippocampus, a person who is thoughtful might make liposomes from three brain beneficial phosphatidyl chemicals, (also possible with phosphatidylserine as well as phosphatidylethanolamine is phosphatidylinositide) with the thought that the liposomes could bring 10HDA (or any other liposomal drug) to a wider range of cyte types and tissues simultaneously; DHA is published as beneficial, I do not know if you can make a liposome that is variously 10% phosphatidylserine 90% DHA, 40/60 DHA with phosphatidylethanolamine , 4/5 or other fractions; Also a person that makes different liposomes to reach different cytotypes and tissues simultaneously might use phosphatidyl chemicals, or methods (apparently you can just shake it in a beaker) that complement ultrasonication to make eentsy, medium, as well as bigger size liposomes even if they all have 10HDA or some other identical ingredient



They could screen a library of new phosphatidyl group containing drugs to find out if any new ones are noticeably beneficial; phosphatidylinositol makes me thing, they could use ribose instead of inositol, and ribose concentrates, beneficially, at the heart and is kind of (I may have read) feeling of energeticness causing, then there are all the phosphatidyl amino acids, also as regards to phosphatidylsugars (like inositol) they could find out if phosphatidyltrehalose is a neuropreservative or possibly causes cytomembranes at neurons to recover from freezing and thawing better or is better at preserving frozen, freeze dried gametes







Going with the concept that 10HDA could benefit the brain, “intranasal administration provides a practical and noninvasive approach to deliver drugs to the brain, allowing in this way an increase in the amount of drugs delivered across the barrier” 10 grams of royal jelly contain 600 mg of 10HDA, so kind of snortable; I do not remember the actual calculation, but if the c elegans dose of .03% of food (or perhaps it was aquaeous medium) is treated as mouse compensation dose, and with mouse 1/6 of body mass food/24 hours then a a human it is between 6 and 60 grams of royal jelly, or perhaps it was pure 10HDA at a human with 46% c elegans greater longevity (also 18% c elegans longevity) dose; a person could look up the papers right now, and calculate the actual numbers; nasal administration of 360 mg of 10DHA seems plausible

Reply all
Reply to author
Forward
0 new messages