Question about the difference between natural synthetic horemones

[agni...@gmail.com]

American cyclist Floyd Landis tested positive for synthetic
testosterone. As I understand it, synthetic testosterone has atoms of
different isotopes then natural testosterone. I know that there some
difference between human and animal insulin. I also understand that
there are some differences in synthetic and human thyroid. Can some
hormones differ in atomic structure or chemically?

[Uncle Al]

Testosterone is testosterone. Testing uses high resolution mass spec
for C-12/C-13 ratios and distribution within ion fragments.
Herbivore- and petroleum-sourced testosterones have characteristic
divergent isotope abundances compared to stone-ground human stuff.

Protein products are typically composition-divergent.

--
Uncle Al
http://www.mazepath.com/uncleal/
(Toxic URL! Unsafe for children and most mammals)
http://www.mazepath.com/uncleal/qz3.pdf

[barry...@yahoo.com.au]

I heard it was isomerism rather than isotopes - the synthetic is a
racemate and the natural is a single enantiomer.
Can anyone give us a definite answer?
Barry

[agni...@gmail.com]

> Protein products are typically composition-divergent.
>
> --
> Uncle Al
> http://www.mazepath.com/uncleal/
> (Toxic URL! Unsafe for children and most mammals)
> http://www.mazepath.com/uncleal/qz3.pdf

Does composition-divergent.mean the same thing as .have different
atoms? When I look up testosterone on the net the sites I go to say
testosterone is a protein. Is testosterone composition-divergent? Or is
testosterone always the same in terms of atoms? Is this true for
insulin?

[luc...@sbcglobal.net]

<barry...@yahoo.com.au> wrote in message
news:1156460698.5...@74g2000cwt.googlegroups.com...

>I heard it was isomerism rather than isotopes - the synthetic is a
> racemate and the natural is a single enantiomer.
> Can anyone give us a definite answer?

Close. First line screening looks for an epimer of natural testosterone,
not an enantiomer--an epimer has one isomerized chiral center, as opposed to
being entirely of the opposite handedness. Since the synthetic stuff is
almost certainly made by elaborating some other readily-available naturally
occurring steroid, most of the chiral scaffolding of the molecule is already
fixed, with only one or two chiral centers introduced in the synthesis.
After a positive first-line screen, the second-line screen is based on the
C-13 content. My understanding is that the unusual epi-testosterone ratio
can (not likely, but can) occur due to abnormal but natural metabolic
processes, but an unusual C-13 content is unequivocally from man-made
material.

Eric Lucas

[luc...@sbcglobal.net]

"Bob" <bbx10...@excite.XYZ.com> wrote in message
news:b6ose25llhe1v9bvb...@4ax.com...

> On 24 Aug 2006 17:13:31 -0700, agni...@gmail.com wrote:
>
>>When I look up testosterone on the net the sites I go to say
>>testosterone is a protein.
>

> Testosterone is not a protein.

Oh, yeah, I meant to reply to that, too. I'd love to see what websites he's
finding that say testosterone is a protein, and how he's finding them.
Misinformation doesn't get any more basic than that.

Eric Lucas

[agni...@gmail.com]

I was wrong it said testosterone effects protiens not they were
protiens. In any case do the atoms in protien hormones differ?

[agni...@gmail.com]

Bob wrote:
> On 24 Aug 2006 17:13:31 -0700, agni...@gmail.com wrote:
>

> >When I look up testosterone on the net the sites I go to say
> >testosterone is a protein.
>
>

> Testosterone is not a protein.
>
>

> Re the Landis issue, look up epi-testosterone vs testosterone. One key
> test involved measuring the ratio of these two chemicals, which is
> very different for natural vs synthetic.
>
>
> bob

I am sorry. I read it wrong. As I understand it peptide hormones are
protiens. Do they differ in atoms?

[David Bostwick]

It's on the Web, so it must be true.

[agni...@gmail.com]

All I wanted to know was can there be different virsons of the same
hormone that differ in atomic structure. Some hormones that are
products of endocrine glands are proteins or peptides; others are
steroids. However as you say all hormones have exactly the same
atoms then then every protines have the same atomic structure.