Does methionine smell?
Ralf Stephan
they have a quite strong H2S-like smell, even through the sugar coating.
As I understand it, methionine is a sulphur-containing amino acid.
Is it normal that this stuff smells or could it be that it does
when it gets older?
Thanks,
ralf
--
Ralf Stephan, Augsburg, Bavaria, Germany ra...@ark.abg.sub.org
GCS/M/S d* -p+ c++ l++ m* s--/+ g++ w++ t+ r+ !x
James_J_...@cup.portal.com
>My doc prescribed me L-methionine pills (Acimethin in Germany) and
>they have a quite strong H2S-like smell, even through the sugar coating.
>
>As I understand it, methionine is a sulphur-containing amino acid.
>Is it normal that this stuff smells or could it be that it does
>when it gets older?
I have noticed that methionine derivatives do tend to have a
characteristic sulfur-based odor, especially if they have decomposed
slightly. I have never had one smell as bad as H2S, however,
but perhaps the methionine they use in pills is not as high grade
as that used as a research chemical?
Jim Kowalczyk James_J_...@cup.portal.com
Eisai Research Institute
Andover, MA
Keith Warren Rickert
it wouldnt take much decomposition however to produce
a quite notable odor.
Personally, if the pill smelled that strongly, and there were
any doubts based on its age etc., I would not take it..H2S
has a remarkably high acute toxicity.
Keith
Richard Parkin
I would be very worried if the answer to the above question is yes...
pharmaceutical chemicals should be of the upmost purity. I would expect that
solvents used, such as anhydrous EtOH, had passed a special purity test. I
know for a fact that when making drugs, normal distilled water cannot be used.
Instead, a specially distilled form with any bacterium taken out also has to be
utilised.
Research chemicals are of a lower grade.
Richard Parkin
bjg...@bb1t.monsanto.com
[Stuff re Purity of Methionine deleted]
>
> I would be very worried if the answer to the above question is yes...
> pharmaceutical chemicals should be of the upmost purity. I would expect that
> solvents used, such as anhydrous EtOH, had passed a special purity test. I
> know for a fact that when making drugs, normal distilled water cannot be used.
> Instead, a specially distilled form with any bacterium taken out also has to be
> utilised.
>
> Research chemicals are of a lower grade.
>
> Richard Parkin
>
This is not always the case, Richard. Pharmaceutical chemicals are of
a specific *defined* purity with a *defined* impurity profile. Once
that profile is registered with the FDA it is very difficult to
change. Also, the *assay* of a pharmaceutical chemical may be lower
than that of a research grade chemical due to such things as moisture.
If rigorous drying raised the assay from, say, 96% to 99% but the
heating caused an impurity to appear at .01% and that impurity was
either new (not in the original impurity profile) or highly toxic,
then the pharmaceutical would be produced at the lower assay.
A prime example, currently being discussed in another thread, is
ethanol. U.S.P. ethanol (for pharmaceutical use) is only 96% pure,
the balance being water. 'Research grade" ethanol is essentially 100%
pure, but may contain traces of benzene or ethylene oxide, which
cannot be allowed in foods or pharmaceuticals.
--
--Electric Monk (Bruce Gaede);
e-mail: bjg...@ccmail.monsanto.com
"The Cardinal laughed an ironic little laugh that almost made him
likable. 'If you are among those who believe that Mary Gonzalez was
ever _my_ creation, you have an interesting experience ahead of you,
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and quite a mind it is.'"
--Norman Spinrad, "Deus X"
David Toland
pharmaceutical chemicals should be of the upmost purity. I would expect that
solvents used, such as anhydrous EtOH, had passed a special purity test. I
know for a fact that when making drugs, normal distilled water cannot be used.
Instead, a specially distilled form with any bacterium taken out also has to be
utilised.
Research chemicals are of a lower grade.
]
This is not strictly true. USP grade chemicals are often of lower purity
than the same chemical in various other grades used in research, but they
are specifically certified to be below given limits in some set of known
contaminants. The process by which they are manufactured is specified,
but they may be actually higher in contaminants which are deemed harmless
for their pharmaceutical application, but which may make them totally
unsuitable for a laboratory application.
The purity grades for chemicals are not a simple ordering, you often must
look at what contaminants are measured/controlled for a particular grade.
--
--------------------------------------------------------------------------
All opinions are MINE MINE MINE, and not necessarily anyone else's.
d...@phlan.sw.stratus.com | "Laddie, you'll be needin' something to wash
(Dave Toland) | that doon with."
Charles Pooley
Methionine is not a living organism, and so does not have any senses,
therefore it cannot smell.
--
Charles Pooley c...@netcom.com GEnie c.pooley
EE consultant, Los Angeles, CA
Paul Ross
answer the long standing question,
How hard is LSD to make ?
I heard someone say that it contained Benzine Rings (sp ?) which made it
a very hard substance to produce. Is this true ? Does anyone have a recipe ?
Also MDMA, I am told that you not only need a well equiped stocked lab
but you have to have an extremely skilled chemist, you can't just make it
from a recipe. Anyway anyone got any ideas ?
Paul
gozdz,antoni s
>How hard is LSD to make ?
>
>I heard someone say that it contained Benzine Rings (sp ?) which made it
>a very hard substance to produce. Is this true ? Does anyone have a recipe ?
>
>Also MDMA, I am told that you not only need a well equiped stocked lab
>but you have to have an extremely skilled chemist, you can't just make it
>from a recipe. Anyway anyone got any ideas ?
After reading your post, I _am_ certain of one thing:
a bozo who can't spell 'benzene' correctly is certainly
incapable of carrying out the total synthesis of LSD.
He will blow himself up working with ether...
Tony
Keith Warren Rickert
Yes, I have some ideas.
I have the idea that its just as illegal to make these drugs as to
buy, use, or sell them.
I have the idea that I wouldnt want to try to make any of these
without a well stocked lab; the kind of junk you could make out of
common household hardware and the like would not work particularly well.
Finally, I have the idea that anyone who would make a substance
such as these from a 'recipe' and even _think_ about putting it into
their own bodies without a decent analysis of purity, knowing what
all significant contaminants were and their toxicity, etc....is
a great fool, and is likely to end up poisoning themself sooner or
later.
Remember all the people who ended up with Parkinsons because of an
impurity in an illegal drug prep (I forget the exact details)
in the 80's...
Keith
Robert C.Haushalter
Sure do Paul. The synthesis is really easy! Those other folks are just
pulling your leg because they don't want you to have any FUN.
Now listen carefully:
Step (1): Dissolve sodium bicarbonate (baking soda) (250g) in a minimum
amount of hot water.
Step (2): Add vinegar till the foaming stops.
Step (3): Add about 1/2 pound of finelt chopped parsely.
Let it stand for a few hours till the bezine rings come out of the
parsely.
Then it's bottoms up! The LSD is pretty dilute at this stage so you'll
have to drink a lot.
Bon Appetite!
--
The opinions are mine..not my company's.
Actually, everything is more complicated
James_J_...@cup.portal.com
Actually, pharmaceuticals are often produced from research grade
(i.e., reagent grade) chemicals. Food chemicals are most definitely
of lower quality. It does not take much (<1% or so) to impart a noticeable
odor to a chemical.
The question is whether the pills in question were considered drugs
or foodstuffs.
Jim Kowalczyk James_J_...@cup.portal.com
Eisai Research Institute "A corporation dedicated to innovative
Andover, MA pharmaceutical research"
Paul Ross
>>I heard someone say that it contained Benzine Rings (sp ?) which made it
>>a very hard substance to produce. Is this true ? Does anyone have a recipe ?
>
>pulling your leg because they don't want you to have any FUN.
Let me point out that my interest arose purely from a discussion that a group
of us were having in a pub. I said that it was extremely complicated and they
all said that it was relatively simple. I wouldn't even consider necking the
stuff it's just to settle a bet.
>Step (1): Dissolve sodium bicarbonate (baking soda) (250g) in a minimum
>amount of hot water.
>
>Step (2): Add vinegar till the foaming stops.
I think that I have seen this reaction somewhere before ................
Ralf Stephan
> I have noticed that methionine derivatives do tend to have a
> characteristic sulfur-based odor, especially if they have decomposed
> slightly. I have never had one smell as bad as H2S, however,
It's not the smell of a roomful of H2S, my previous description was
a bit exaggerated, but definitely the smell of an egg salad that was
standing too long...
Thanks for the answers. I'll check with the doc.
--
--| Ralf Stephan, Augsburg, Bavaria, Germany |-------| ra...@ark.abg.sub.org |-
--| GO d* -p+ c++ l++ m* s--/+ g++ w++ t+ r+ |-------| electrons for rent |-
kk...@vax.oxford.ac.uk
The drug prep was MDMA, made up with the usual collection of household goods by
bozos. The instance is now used as an example in toxicological epidemiology and
chemistry courses of the consequences of playing silly buggers with chemistry
sets.
KJK (usual disclaimers)
David Henry Fetter
#include <really_hot_flame.h>
main()
{
The drug prep was ABSOLUTELY NOT MDMA!!!!!!
It was MPPP, an analogue of meperidine. Meperidine, or Demerol,
is an opioid analgesic with a street value. It does not even
remotely resemble MDMA either in structure, chemistry, or actions.
The resulting compound, MPTP, was made by heating the reaction
mixture to get a quicker yield. The "bozo" was a former
graduate student in chemistry.
DO YOUR HOMEWORK BEFORE YOU POST instead
of playing silly buggers with keyboards.
}
--
vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv
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> David Fetter # Duct tape is like the Force: <
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> (414) 229-3975 (SAACS) # and a Dark side and it <
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> 2602 E. Hampshire # <
> Milwaukee, WI 53211 # --Carl Zwanzig <
> # <
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
Richard Parkin
>Yes, I have some ideas.
>I have the idea that its just as illegal to make these drugs as to
>buy, use, or sell them.
>I have the idea that I wouldnt want to try to make any of these
>without a well stocked lab; the kind of junk you could make out of
>common household hardware and the like would not work particularly well.
>Finally, I have the idea that anyone who would make a substance
>such as these from a 'recipe' and even _think_ about putting it into
>their own bodies without a decent analysis of purity, knowing what
>all significant contaminants were and their toxicity, etc....is
>a great fool, and is likely to end up poisoning themself sooner or
>later.
>Remember all the people who ended up with Parkinsons because of an
>impurity in an illegal drug prep (I forget the exact details)
>in the 80's...
>Keith
>
I believe it was in Pasadena, CA, where some kids were trying to make a drug
in their basement...They accidentally made MPTP, which reacts in the body to
form MPP+, a radical that will react with a certain receptor in the brain,
leading to disaterous results. At least some good came out of this, being that
they could research new ideas for treating Parkinson's..
Richard Parkin
Ralf Stephan
> The question is whether the pills in question were considered drugs
> or foodstuffs.
Drugs. They are used to lower urine pH by producing (SO4)2- ions.
Dosage is several grams a day.
neoph...@gmail.com
Dean
> For the record, fresh powdered methionine that is used in pharmaceutical labs smells like fried food -quite strongly too. The next person in the lab can always tell what's been going on because the place temporarily smells like McDonalds :P
