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life extension foundation product:
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Treon Verdery
Oct 4, 2022, 4:06:22 AM10/4/22
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Beauty topical drug: Royal jelly is a previously published beauty drug that causes skin to reflect even more light, noting that 10HDA is published as being a calorie-restriction (possibly autophagy causing) function the same as chemical, harmless edible oil extracted (concentrated) 10HDA at liposomes could actually do, and be measured as causing, beneficial tissue youthifying autophagy at the dermis; as a life extension foundation product, oil extracted (concentrated) 10HDA could be a one pill, functions like 20 grams of royal jelly equivalent drug, and they could use their insilico c elegans longevity characterizer to measure the longevity benefit, published at 46% at daf mutant c elegans; also the life extension foundation could possibly find a plant based source of 10HDA that is particularly mass producible and affordable
another library to screen is “DNA repair proteins” that is mentioned in a scientific paper so rather than being a general kind of thing, it is possible it is a particular group of things, I am reminded of when they fed mice things coated with enteric stomach-passsing enteric acryl polymers; (kind of like an enteric capsule at humans) they could feed mice the full published range of different DNA repair proteins, with an enteric coating, to find out if there is longevity, wellness, as well as healthspan benefit
On occasion, a plant extract has longevity effects, fisetin is a longevity increasing published senolytic plant extract; I think researched new human origin molecule pharmaceuticals are much more effective and beneficial at causing greater longevity, lifespan, wellness, and healthspan, it is possible that DNA chromatin active HDIs and HDACs and a variety of other chromatin-accessibility chemicals might already be made at plants and concentrated, these plant based HDIs and HDACs and other chromatin accessibility modifying chemicals could be beneficially screened to find out if they are longevity, wellness, healthspan drugs, creating a new plant based longevity drug
There is also the possibility that plant based chromatin accessibility modulators like HDIs and HDACs as well as other chromatin accessibility chemicals that cause greater longevity could be genetically engineered into a variety of food plants, further developing and supporting the creation of food plants that cause much greater human lifespan
There are whales with multicentury lifespans, do they face cardiovascular, cancer, or completely different risk? Pleasantly and benevolently, if possible (whale communications) voluntarily, could they be fed something or depot-injected to cause even greater whale longevity; longevity genetics at multicentury lifespan whales if they (just happen) to be different than cardiovascular or cancer risks could suggest a genetics of minimization of risk to humans from other risks as well as cardiovascular and cancer risks
Making liposomes that reach varying areas of the brain and body; I read that there is research on liposomes, some with surface moeities, that can pass the blood brain barrier. There is a chart at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258547/ where lipids of different C amounts are arranged, and some C amounts like C16 can be 2 orders of magnitude different than like C22:6, and that amounts in different brain tissues can be near 90 times higher than other lipids, that suggests that if you make liposomes out of these things they might automatically sort to very different brain tissues and locations just based on the C length of something that is already a form of phosphatidylserine, phosphatidylethanolamine, or phosphatidylcholine;
Fatty acid
Fatty Acyl Composition (% of total fatty acid in each phospholipid class)
Phosphatidylserine
Phosphatidylethanolamine
Phosphatidylcholine
Gray matter
White matter
Gray matter
White matter
Gray matter
White matter
Aa
Bb
A
B
A
B
A
B
A
B
A
B
16:0
2.3
4.2
1.7
1.9
6.7
5.7
6.7
3.4
45.0
45.9
34.3
30.2
16:1
0.3
0.3
0.4
0.3
0.4
0.4
1.4
0.5
3.1
2.4
1.0
2.3
18:0
25.4
45.3
35.8
44.1
26.0
28.4
9.0
9.3
9.3
11.2
13.4
12.9
18:1
21.5
14.0
39.7
41.4
11.9
10.3
42.4
38.9
31.4
30.3
45.2
47.1
20:4
1.6
3.0
2.0
1.2
13.8
11.2
6.4
16.5
4.1
3.6
1.3
0.8
22:5n-6
5.0
0.7
4.8
0.1
14.3
1.2
13.7
0.7
ndc
trd
nd
0.2
22:5n-3
3.3
0.5
0.9
0.2
tr
1.1
0.5
0.9
nd
tr
0.3
0.3
22:6
36.6
23.2
5.6
1.3
24.3
30.5
3.4
8.6
3.1
2.5
0.1
0.2
Also as to screening a library, they could feed these 48 different C length lipids to 8 mice each, measure their cognition, and emotional affect, and find out if any C lengths of these phosphatidyl chemicals have much stronger effects than things like DHA and EPA on mental processes
another library to screen is “DNA repair proteins” that is mentioned in a scientific paper so rather than being a general kind of thing, it is possible it is a particular group of things, I am reminded of when they fed mice things coated with enteric stomach-passsing enteric acryl polymers; (kind of like an enteric capsule at humans) they could feed mice the full published range of different DNA repair proteins, with an enteric coating, to find out if there is longevity, wellness, as well as healthspan benefit
On occasion, a plant extract has longevity effects, fisetin is a longevity increasing published senolytic plant extract; I think researched new human origin molecule pharmaceuticals are much more effective and beneficial at causing greater longevity, lifespan, wellness, and healthspan, it is possible that DNA chromatin active HDIs and HDACs and a variety of other chromatin-accessibility chemicals might already be made at plants and concentrated, these plant based HDIs and HDACs and other chromatin accessibility modifying chemicals could be beneficially screened to find out if they are longevity, wellness, healthspan drugs, creating a new plant based longevity drug
There is also the possibility that plant based chromatin accessibility modulators like HDIs and HDACs as well as other chromatin accessibility chemicals that cause greater longevity could be genetically engineered into a variety of food plants, further developing and supporting the creation of food plants that cause much greater human lifespan
There are whales with multicentury lifespans, do they face cardiovascular, cancer, or completely different risk? Pleasantly and benevolently, if possible (whale communications) voluntarily, could they be fed something or depot-injected to cause even greater whale longevity; longevity genetics at multicentury lifespan whales if they (just happen) to be different than cardiovascular or cancer risks could suggest a genetics of minimization of risk to humans from other risks as well as cardiovascular and cancer risks
Making liposomes that reach varying areas of the brain and body; I read that there is research on liposomes, some with surface moeities, that can pass the blood brain barrier. There is a chart at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258547/ where lipids of different C amounts are arranged, and some C amounts like C16 can be 2 orders of magnitude different than like C22:6, and that amounts in different brain tissues can be near 90 times higher than other lipids, that suggests that if you make liposomes out of these things they might automatically sort to very different brain tissues and locations just based on the C length of something that is already a form of phosphatidylserine, phosphatidylethanolamine, or phosphatidylcholine;
Fatty acid
Fatty Acyl Composition (% of total fatty acid in each phospholipid class)
Phosphatidylserine
Phosphatidylethanolamine
Phosphatidylcholine
Gray matter
White matter
Gray matter
White matter
Gray matter
White matter
Aa
Bb
A
B
A
B
A
B
A
B
A
B
16:0
2.3
4.2
1.7
1.9
6.7
5.7
6.7
3.4
45.0
45.9
34.3
30.2
16:1
0.3
0.3
0.4
0.3
0.4
0.4
1.4
0.5
3.1
2.4
1.0
2.3
18:0
25.4
45.3
35.8
44.1
26.0
28.4
9.0
9.3
9.3
11.2
13.4
12.9
18:1
21.5
14.0
39.7
41.4
11.9
10.3
42.4
38.9
31.4
30.3
45.2
47.1
20:4
1.6
3.0
2.0
1.2
13.8
11.2
6.4
16.5
4.1
3.6
1.3
0.8
22:5n-6
5.0
0.7
4.8
0.1
14.3
1.2
13.7
0.7
ndc
trd
nd
0.2
22:5n-3
3.3
0.5
0.9
0.2
tr
1.1
0.5
0.9
nd
tr
0.3
0.3
22:6
36.6
23.2
5.6
1.3
24.3
30.5
3.4
8.6
3.1
2.5
0.1
0.2
Also as to screening a library, they could feed these 48 different C length lipids to 8 mice each, measure their cognition, and emotional affect, and find out if any C lengths of these phosphatidyl chemicals have much stronger effects than things like DHA and EPA on mental processes
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