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c892...@cc.nu.oz
May 21, 1990, 3:41:05 AM5/21/90
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This is a summary on a paper of endocronology .THE EFFECT OF GLUCOCORTICOIDS AND M
THE EFFECT OF cAMP PROTEIN KINASE ACTIVITY ON THE BINDING OF RECEPTOR OF THE
TARGET CELL TO THE STEROID AND THE CONSEQUENT LYSIS OF THE T_LYMPHOMA CELL ON
MURINE ANIMALS.
THE OBJECTIVE WAS TO UNDERSTAND MORE THE MECHANISMS BY WHICH GLUCOCORTICOIDS
CAUSE THE LYSIS OF THE TARGET CELL AND TO UNDERSTAND THE DECREASED SENSITIVITY
OF T_LYMPHOMA CELLS TO GLUCOCORTICOIDS. The decreased sensitivity was due to a
decreased amount of cAMP protein kinase activity.In the presense of cAMP
protein kinase activity the T-Lymphoma cells become more sensitive to the
steroid and as a result less amounts of the steroid are needed for the lysis of
the target cell to occur.This is a breakthrough in the proper treatment
of patients suffering of ACUTE LEUKEMIA.
The steroid binds to the receptor of the target cell within the cytosol
andf when this occurs the receptor goes through a conformational change
upon its dephosphorilation, exposing mRNA binding sites ;this exposed sites
bind to the mRNA molecule within the nucleus of the cell ,to specific points
in the chromatid. Hence in this way the steroid regulates protein synthesis
upon the activation of the steroid ,this steroid interacts with the lysosomal
menbrane causing it to break and as a result LYSIS OF THE CELL OCCURS.
HOPE YOU FIND THIS BIT OF INFO INTERESTING
MARIA D. DEPARTMENT OF BIOLOGICAL SCIENCES. NEWCASTLE UNIVERSITY .1990.
21/5/90.
THE EFFECT OF cAMP PROTEIN KINASE ACTIVITY ON THE BINDING OF RECEPTOR OF THE
TARGET CELL TO THE STEROID AND THE CONSEQUENT LYSIS OF THE T_LYMPHOMA CELL ON
MURINE ANIMALS.
THE OBJECTIVE WAS TO UNDERSTAND MORE THE MECHANISMS BY WHICH GLUCOCORTICOIDS
CAUSE THE LYSIS OF THE TARGET CELL AND TO UNDERSTAND THE DECREASED SENSITIVITY
OF T_LYMPHOMA CELLS TO GLUCOCORTICOIDS. The decreased sensitivity was due to a
decreased amount of cAMP protein kinase activity.In the presense of cAMP
protein kinase activity the T-Lymphoma cells become more sensitive to the
steroid and as a result less amounts of the steroid are needed for the lysis of
the target cell to occur.This is a breakthrough in the proper treatment
of patients suffering of ACUTE LEUKEMIA.
The steroid binds to the receptor of the target cell within the cytosol
andf when this occurs the receptor goes through a conformational change
upon its dephosphorilation, exposing mRNA binding sites ;this exposed sites
bind to the mRNA molecule within the nucleus of the cell ,to specific points
in the chromatid. Hence in this way the steroid regulates protein synthesis
upon the activation of the steroid ,this steroid interacts with the lysosomal
menbrane causing it to break and as a result LYSIS OF THE CELL OCCURS.
HOPE YOU FIND THIS BIT OF INFO INTERESTING
MARIA D. DEPARTMENT OF BIOLOGICAL SCIENCES. NEWCASTLE UNIVERSITY .1990.
21/5/90.
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