The 0.2.22 is some kind of unofficial version. I suspect it corresponds to Scan Tailor Experimental build 2016-02-22, which is the latest one. Still, I would stick to official builds from
https://github.com/Tulon/scantailor/releases. There is no portable version being offered, though copying the installation directory should still work.
As for 64bit version not working, try installing this package:
It shouldn't be required, though it could still help.
Also make sure this update is installed if you are on Windows 8.1 or earlier:
Finally, Scan Tailor Experimental no longer supports Windows XP or earlier.