NIST and SBSC engagement with the Flow Cytometry Working Group project

[Marc Salit]

Dear FC Working Group -- 

Congratulations on the results from the recent team interlab experiment. It's consistent with interlab-study experience that successive rounds of measurements identify factors that give rise to bias and variability, and that refined methods are developed to control the measurements and achieve harmony. 

While our NIST team encourages you to pursue this work, we are not able continue our involvement. Please note our shared perspective below:

• the possibility of having shared reference objects to ratio samples-of-interest to is scientifically and technically interesting. 

• the results of the 2nd interlab study do not support the assertion that beads are better reference objects than biological entities. 

• the results _do_ support the assertion that beads can be used as reference objects within the observed performance and scope... which is perhaps rationale to do a 3rd round of a study.
• if you decide to pursue this, we recommend that you implement a 3rd interlab with all strains grown to similar densities so you can compare the use of beads as a reference to the use of frozen e. coli strains as a reference.

• as the NIST team don't have resources to continue this work... 
• we'd ask to be recognized in any acknowledgement of a publication, but not to co-author a publication in this area at this time.
• we'd ask that any inspiration from the SBSC workshops and working group be acknowledged as well, but we cannot establish an imprimatur of SBSC for this work.

I understand that this was discussed at the WG meeting on Monday.

We'll work with you to migrate this mailing list (the google group) and data repository to a new site(s) of your choice. This list will be maintained as an archive, as will the data repository.

We will also follow-up with the SBSC Steering Committee to update them on SBSC-relevant portfolio and strategy going forward.

Cheers and best regards -

Marc, Dave, Sarah, and Ariel

[Jake Beal]

Thank you to Marc and the rest of the team for your help and support, which has gotten us to the edge of what we hope to be a strong result that will significantly improve things for many practitioners.

While we are sad that NIST's resource restrictions limit your involvement, the core group that has been executing the study thus far has made plans to continue and expand, hopefully bringing these results to a deployable state.

To all people on the SBSC flow mailing list: if you wish to remain involved and have not already told me this, please email me and I will put you on the new mailing list.

Thanks,

-Jake

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