Primary Care Dermatology Literature December 2025
Skin Research in Primary Care
Emmanuel Pio Pastore
Ann Rheum Dis. 2025 Nov 27:S0003-4967(25)04529-7. doi: 10.1016/j.ard.2025.11.002.
No abstract available
Noah Keime, Oliver Titus, Monika Ziogaite, Jeremy Hugh, Lisa M Schilling, Robert Dellavalle, Sarah J Billups
J Manag Care Spec Pharm. 2025 Dec;31(12):1237-1243. doi: 10.18553/jmcp.2025.31.12.1237.
Abstract:
Objective: To characterize differences in prescribing patterns for high- vs lower-cost dermatologic agents for acne between dermatologists and primary care physicians (PCPs).
Conclusions: Dermatologists prescribed a higher percentage of high-cost medications for acne. These differences resulted in a slightly higher distribution of costs to the patient but lower for the insurer, as median is a better indicator of the cost distribution. System processes to identify high-cost combination medications and provide low-cost alternatives may further reduce costs.
Hannah R Chang, Hsing-Jou Su, Karin Kartawira, Anna Grossberg, Joy Wan
Pediatr Dermatol. 2025 Nov-Dec;42(6):1176-1178. doi: 10.1111/pde.15972. Epub 2025 May 31.
Abstract: Atopic dermatitis (AD) is a common and chronic skin disease that adversely impacts physical, mental, and social health. Because patients' experience of AD may not correlate with traditional clinician-reported assessments of disease burden, patient-reported outcomes (PROs) are important for understanding the full experience of AD in children and their caregivers. In this pilot study involving 153 children with AD, we found that collecting PROs during routine pediatric AD care is both feasible and acceptable. These findings support future efforts to implement PROs in clinical practice to promote patient-centered care and facilitate shared decision-making.
Sirag Elaribi, Ausama Atwan
Cureus. 2025 Oct 29;17(10):e95721. doi: 10.7759/cureus.95721. eCollection 2025 Oct.
Abstract:
Aim: To evaluate diagnostic outcomes and management decisions from primary care skin lesion referrals assessed via teledermoscopy across urgent suspected cancer (USC), urgent, and routine pathways.
Conclusion: Teledermoscopy safely reduced unnecessary FTF consultations and efficiently identified high-risk lesions. Most USC referrals were ultimately benign, highlighting the need to strengthen diagnostic confidence in primary care.
Norhane Nadour, Théo Duguet, Sophie Zahedi, Hugo Figoni, Roxane Liard
BMC Prim Care. 2025 Nov 28;26(1):384. doi: 10.1186/s12875-025-03073-9.
Abstract:
Context: Artificial intelligence (AI) technologies are increasingly used for image recognition, especially for skin lesions. Due to what may be long wait times for dermatology appointments, general practitioners (GPs) are the gatekeepers when it comes to skin diseases requiring rapid treatments.
Conclusion: AI appears to perform at a similar level to dermatologists, and the same is true when comparing AI to GPs. This is especially true for serious conditions like melanoma, suggesting that AI could be a valuable tool for GPs in improving patient care.
Impact of adalimumab treatment on impairment of non-professional activities in psoriasis patients
Georgios Kokolakis, Sandra Philipp, Thomas Mosch, Björn Fritz, Robert Sabat
J Dtsch Dermatol Ges. 2025 Nov 28. doi: 10.1111/ddg.15949. Online ahead of print.
Abstract:
Background and objectives: Psoriasis can result in reduced quality of life, work productivity loss, and a significant restriction in non-professional activities. This study investigates the effects of long-term treatment with adalimumab regarding work ability, non-professional activities, and health-related quality of life in a large real-word population in Germany.
Conclusions: Long-term treatment with adalimumab had a favorable impact on clinical outcomes, employment-related aspects, practice of non-professional activities, and health-related quality of life in psoriasis patients.
Implementation and Impact of a Dermoscopy-Enabled Dermatology eConsult Application in Primary Care
Lauren Bifulco, Daren R Anderson, Niels Kvorning Ternov, Elizabeth V Seiverling
J Prim Care Community Health. 2025 Jan-Dec:16:21501319251403076. doi: 10.1177/21501319251403076. Epub 2025 Dec 8.
Abstract:
Introduction/objectives: Primary care providers (PCPs) can help fill gaps in access to dermatology care using eConsults to collaborate asynchronously with dermatologists. Many dermatology eConsult programs face challenges with image acquisition, image quality, lack of dermoscopy and complicated, time-consuming workflows that limit primary care acceptance.
Conclusion: Broad adoption of DermLoop eConsults helped provide effective dermatology care to Medicaid-insured and uninsured patients who may otherwise have been unable to obtain care.
Effectiveness of emulsion bathing in adult patients with atopic dermatitis
Duy Le Pham, Nguyet Doan Lam Nguyen, Quoc Quang Luu
Asia Pac Allergy. 2025 Dec;15(4):263-267. doi: 10.5415/apallergy.0000000000000186.
Abstract:
Background: Emulsion bathing has been commonly advised in the management of atopic dermatitis (AD) to maintain skin hydration and reduce the negative effects of soaps on the skin barrier. However, there is limited scientific evidence from randomized controlled trials to support their effectiveness.
Conclusion: Emulsion bathing helped prevent epidermal damage induced by bathing. However, the combination of emulsion bathing and moisturization did not show superiority over moisturization alone in improving skin hydration after bathing.
Investigating the health economic burden of atopic disease in children from the EAT-On Study
Ru-Xin Foong, Joanna Craven, George Du Toit, Helen A Brough, Alexandra F Santos, Gideon Lack, Tracey H Sach
Pediatr Allergy Immunol. 2025 Dec;36(12):e70256. doi: 10.1111/pai.70256.
Abstract:
Background: There is growing interest in the health economic burden of childhood diseases. This study aimed to compare healthcare costs between atopic and non-atopic children in a general UK population.
Conclusion: Children with atopy incur greater total healthcare costs compared to children without atopy.
The effect of shingles vaccination at different stages of the dementia disease course
Min Xie, Markus Eyting, Christian Bommer, Haroon Ahmed, Pascal Geldsetzer
Cell. 2025 Dec 2:S0092-8674(25)01256-5. doi: 10.1016/j.cell.2025.11.007.
Abstract: Using natural experiments, we have previously reported that live-attenuated herpes zoster (HZ) vaccination appears to have prevented or delayed dementia diagnoses in both Wales and Australia. Here, we find that HZ vaccination also reduces mild cognitive impairment diagnoses and, among patients living with dementia, deaths due to dementia. Exploratory analyses suggest that the effects are not driven by a specific dementia type. Our approach takes advantage of the fact that individuals who had their eightieth birthday just after the start date of the HZ vaccination program in Wales were eligible for the vaccine for 1 year, whereas those who had their eightieth birthday just before were ineligible and remained ineligible for life. The key strength of our natural experiments is that these comparison groups should be similar in all characteristics except for a minute difference in age. Our findings suggest that live-attenuated HZ vaccination prevents or delays mild cognitive impairment and dementia and slows the disease course among those already living with dementia.
Calcineurin Inhibitors: Current Role, Toxicity Management, and Future Frontiers in Immunosuppression
Ayush Mistry, Anwesha Bhattacharya, Moitri Mondal, Soumik Bhattacharjee, Arghya Bhattacharya, Sruti Bagchi Ghosh, Mohammed A Kabsh, Mohanned Talal Alharbi, Mohammed Ali A Majrashi, Mohammed Kamal Nagshabandi, Muyassar Khaled Tarabulsi, Fatma M El-Demerdash, Mohamed M Abdel-Daim, Bikram Dhara, Daniel Ejim Uti
Mol Neurobiol. 2025 Dec 9;63(1):275. doi: 10.1007/s12035-025-05549-2.
Abstract: Cyclosporine, tacrolimus, pimecrolimus and newer derivatives of cyclosporine such as voclosporin are calcineurin inhibitors (CNIs), have a potent immunosuppressant effect. They act by inhibiting the calcium dependent phosphatase, calcineurin. This process inhibits the phosphorylation of Nuclear Factor of Activated T-cells (NFAT) and the transcription of IL-2, which results in impaired T-cell activation. CNIs are important agents of transplant immunosuppression and are called in many auto-immune diseases. Dual disease-modifying antirheumatic drugs (DMARDs) and new immunomodulatory agents (IIAs), including voclosporin for lupus nephritis and pimecrolimus for atopic dermatitis, have led to stimulate further treatment possibilities in middle- and high-income countries (HICs). Although the treatment via CNI is effective, they cause serious dose-related side effects; these are nephrotoxicity, hypertension, neurotoxicity and metabolic disturbances. This necessitates the need of continuous monitoring of drug concentrations and management of cardiovascular and metabolic risk factors. This narrative review summarizes the mechanism(s), the current clinical application(s), the safety concern(s), and the future direction(s) of the safer and targeted use of CNIs.
The effect of shingles vaccination at different stages of the dementia disease course
Min Xie, Markus Eyting, Christian Bommer, Haroon Ahmed, Pascal Geldsetzer
Cell. 2025 Dec 11;188(25):7049-7064.e20. doi: 10.1016/j.cell.2025.11.007. Epub 2025 Dec 2.
Abstract: Using natural experiments, we have previously reported that live-attenuated herpes zoster (HZ) vaccination appears to have prevented or delayed dementia diagnoses in both Wales and Australia. Here, we find that HZ vaccination also reduces mild cognitive impairment diagnoses and, among patients living with dementia, deaths due to dementia. Exploratory analyses suggest that the effects are not driven by a specific dementia type. Our approach takes advantage of the fact that individuals who had their eightieth birthday just after the start date of the HZ vaccination program in Wales were eligible for the vaccine for 1 year, whereas those who had their eightieth birthday just before were ineligible and remained ineligible for life. The key strength of our natural experiments is that these comparison groups should be similar in all characteristics except for a minute difference in age. Our findings suggest that live-attenuated HZ vaccination prevents or delays mild cognitive impairment and dementia and slows the disease course among those already living with dementia.
Ane Marie Hovmand Nøhr, Pernille May Hansen, Michael Møller-Hansen, Henrik Hedegaard Pliess Larsen, Amalie Thorsti Møller Rønnstad, Simon Francis Thomsen, Claus Otto Carl Zachariae, Kristina Ibler, Charlotte G Mortz, Carsten Bindslev-Jensen, Mette Sondergaard Deleuran, Christian Vestergaard, Peter Bjerring, Jacob P Thyssen, Steffen Heegaard
Dermatology. 2025;241(5-6):415-424. doi: 10.1159/000548467. Epub 2025 Sep 13.
Abstract:
Introduction: New biologic treatments are increasingly used for the treatment of moderate-to-severe atopic dermatitis (AD). This study examined clinical characteristics of patients with Dupilumab-associated ocular surface disease (DAOSD).
Conclusion: DAOSD should be recognized by dermatologists and should lead to consideration of early referral to ophthalmologists.