Primary Care Dermatology Literature June 2025
Skin Research in Primary Care
Association between atopic disorders and mental ill health: a UK-based retrospective cohort study
Sonica Minhas, Joht Singh Chandan, Rebecca Knibb, Lavanya Diwakar, Nicola Adderley
BMJ Open. 2025 May 31;15(5):e089181. doi: 10.1136/bmjopen-2024-089181.
Abstract:
Objective: To examine the mental ill health burden associated with allergic and atopic disorders, in a UK primary care cohort.
Conclusion: There is an increased risk of mental ill health disorders among patients with diagnosis of an allergic and atopic disorders. There is a need to consider dual delivery of allergy and psychology services to optimise mental well-being among this cohort.
Laura K Ferris, Erik Jaklitsch, Elizabeth V Seiverling, Thomas Agresta, Peggy Cyr, Laurie Caines, Na Wang, Daniel M Siegel
J Prim Care Community Health. 2025 Jan-Dec:16:21501319251342106.
Abstract:
Background: Elastic Scattering Spectroscopy (ESS), an optical tissue sampling technique, distinguishes between benign and malignant tissue in vivo without the need to perform a surgical biopsy. A handheld device that employs ESS enabled with an artificial intelligence algorithm was developed as an objective tool to aid primary care physicians (PCPs) in their management of lesions suspicious for skin cancer. The aim of this study was to assess and compare the diagnostic and management performance of PCPs with and without the use of the ESS device in detecting skin cancer.
Conclusion: Use of the ESS device output by PCPs significantly improved their diagnostic and management sensitivities as well as their overall management performance. The findings suggest the ESS device can improve PCP skin cancer detection and confidence in their skin lesion evaluation and management.
Toni Maria Janke, Beke Hester, Katharina Müller, Christine Blome, Theresa Klinger, Brigitte Stephan, Matthias Augustin, Kristina Hagenström
BMJ Open. 2025 May 30;15(5):e098802. doi: 10.1136/bmjopen-2025-098802.
Abstract:
Objectives: Alopecia areata (AA) is a chronic immune-related disease with non-scarring hair loss. Treatment may reduce disease activity but cannot cure. Even though AA can be very burdensome to patients, the German social act has categorised AA as a 'lifestyle disease' and treatment is not covered by statutory health insurances (SHI). We aimed to characterise the healthcare situation of patients with AA in Germany, including potential inequalities, and to derive recommendations for action.
Conclusions: The disease burden and frustration of patients with AA is high, mostly caused by limited treatment options and lack of reimbursement, limiting access to approved drugs such as Janus kinase inhibitors. Through the mixed-methods design, we were able to combine patient experiences and quantitative data reflecting the reality of healthcare in Germany.
Parameters linked with higher Itch Severity in Chronic Spontaneous Urticaria - CURE Results
Jules Stolz, Pascale Salameh, Riccardo Asero, Emek Kocatürk, Jonny Peter, Clive Grattan, Leonie S Herzog, Melba Muñoz, Joachim Dissemond, Petra Staubach-Renz, Andrea Bauer, Simon Francis Thomsen, Ana M Giménez-Arnau, Maria Puertolas, Alexis Bocquet, Michael Makris, Stamatios Gregoriou, Maryam Khoshkhui, Samaneh Kouzegaran, Martijn Bastiaan Adriaan van Doorn, Alicja Kasperska-Zajac, Maciej Gąsior, Magdalena Zając, Elena Latysheva, Daria Fomina, Elena Kovalkova, Gerelma Andrenova, Elizaveta Sedova, Alexandr Vitchuk, Mojca Bizjak, Mitja Košnik, Kanokvalai Kulthanan, Papapit Tuchinda, Cascia Day, Mimi Deetlefs, Felix Aulenbacher, Karsten Weller, Pavel Kolkhir, Martin Metz, Manuel P Pereira
J Allergy Clin Immunol Pract. 2025 May 28:S2213-2198(25)00498-2. doi: 10.1016/j.jaip.2025.05.033.
Abstract:
Objective: To analyze factors associated with itch severity, and how itch is associated with quality of life and healthcare utilization in CSU.
Conclusion: Higher itch levels are associated with inflammation and depression and are linked to worse quality of life and increased healthcare demand. Addressing itch is crucial to reducing the humanistic and societal burden in CSU.
David E Goldsbury, Damien McCarthy, Caroline G Watts, Chi So, Olivia Wawryk, Chris Kearney, Gillian Reyes-Marcelino, Kirstie McLoughlin, Jon Emery, Anne E Cust
Public Health Res Pract. 2024 Jun:35:PU24003. doi: 10.1071/PU24003.
Abstract:
Objectives: To describe patterns of skin checks for potential skin cancers
in general practice and subsequent skin-related healthcare, and the associated
costs. Study type Retrospective longitudinal health record linkage.
Conclusions: Skin checks for potential skin cancers occur frequently in Australian general practice and accumulate substantial health system costs, with one in five skin checks resulting in subsequent treatment. This study adds to scarce real-world skin check and cost data in Australia.
A Clinical Prediction Model to Assist Screening Patients for Scabies in Primary Care
Sanskruti Zaveri, Tarun Nambiar, Simon Thornley, Vanessa Selak, Gerhard Sundborn, Rachel Roskvist, Arthur J Morris
J Paediatr Child Health. 2025 May 29. doi: 10.1111/jpc.70100. Online ahead of print.
Abstract:
Aim: To develop and test a clinical prediction model based on demography and symptoms to assist in screening for scabies diagnosis in primary care.
Conclusion: Simple logistic models based on common symptoms of scabies, especially itch in the child and 'simultaneous itch in the family', accurately predict scabies status. Such tools have potential use in supporting screening and improving diagnosis of scabies in community and primary care settings.
Farhanah Paruk, Dzifa Dey, Anisa Mosam, Oluwaytoyin Christina Amira, Mohammed Tikly
Lupus. 2025 May 28:9612033251344059. doi: 10.1177/09612033251344059.
Abstract:
Introduction: Previous studies indicate that the prognosis of systemic lupus erythematosus (SLE) is poor in Africa. We surveyed African physicians for their perceptions of factors that impact negatively on optimal SLE care and interventions to improve care in Africa.
Conclusion: The study reveals that the primary reasons for late diagnosis of SLE in Africa are lack of awareness among primary healthcare doctors and financial constraints. Thus, the need for greater financial resources, especially for appropriate medications, medical education and improving patient understanding of the disease through support groups, to improve SLE care and outcomes in Africa.
Lisa P van der Rijst, Marjolein S de Bruin-Weller, Nicolaas P A Zuithoff, Saskia Spillekom-van Koulil, Marieke M B Seyger, Marlies de Graaf
J Dermatolog Treat. 2025 Dec;36(1):2503273. doi: 10.1080/09546634.2025.2503273.
Abstract:
Purpose: Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups.
Conclusions: Young AD patients and caregivers strive to reduce itch and lesions with effective and safe treatment. Goals and preferences differ within individuals at different stages of life, highlighting the importance of addressing individual needs to improve patient-centered care.
Anna Dattolo, Francesca Sampogna, Simona Mastroeni, Luca Fania, Davide Ciccone, Damiano Abeni
Dermatol Reports. 2025 May 23;17(2). doi: 10.4081/dr.2024.10086. Epub 2024 Oct 16.
Abstract: Hidradenitis suppurativa (HS) is a chronic, skin-immunemediated inflammatory disease (sIMID), with a high impact on quality of life (QoL). Data on clinical management, comorbidities, psychosocial burden, and psychiatric disorders in pediatric patients with HS are scarce. The aim of our study was to compare clinical characteristics and patient-reported outcome measures (PROMs) for health-related quality of life (HRQoL) in adult and pediatric patients with HS. Data were collected on 601 patients with HS, 60 of whom (10.0%) were pediatric. The psychological and HRQoL impact was generally higher in adults than children, but it was also noteworthy in pediatric patients. Early diagnosis and interventions based on education for the patients and their families and psychological support are the key to optimal disease management and adherence. Our study underlines the need for screening for HS-associated psychiatric disorders and for using age-specific tools to evaluate HRQoL. A multidisciplinary approach involving several specialists is needed, as well as liaison with primary care specialists to improve care and management of comorbidities and psychological issues in patients with HS.
Linda Torres, Charlotte A Jonsson, Björn Eliasson, Helena Forsblad-d'Elia, Anton J Landgren, Annelie Bilberg, Inger Gjertsson, Ingrid Larsson, Eva Klingberg
BMC Rheumatol. 2025 May 23;9(1):58. doi: 10.1186/s41927-025-00511-0.
Abstract conclusions: Weight loss was associated with reduced levels of serum biomarkers related to inflammation and cartilage degradation, and increased biomarkers for bone resorption. The study supports the strong relationship between obesity, inflammation, bone and cartilage metabolism, identifying BMI as a possible confounder for biomarker levels.
Sunita Singh, Niraj Kumar Srivastava, Amrita Upadhyaya, Mrityunjay Kumar, Neeraj Pawar, Rohit Kapoor
J Indian Assoc Pediatr Surg. 2025 May-Jun;30(3):308-316. doi: 10.4103/jiaps.jiaps_256_24.
Abstract conclusion: 0.5%-TTM solution can be a first-line therapy for SIH due to its rapid onset of action and overall comparable efficacy in reducing SIH size. While clobetasol remains effective, its slower response may limit its utility.
Unraveling Multimorbidity Patterns of Psoriasis Using Network Analysis
M Almenara-Blasco, J Carmona-Pírez, T Gracia-Cazaña, B Poblador-Plou, C Laguna-Berna, A Moreno-Juste, A Navarro-Bielsa, A Gimeno-Miguel, Y Gilaberte
Actas Dermosifiliogr. 2025 May 20:S0001-7310(25)00304-7. doi: 10.1016/j.ad.2025.05.005.
Abstract:
Objectives: To identify comorbidity patterns in psoriatic patients
using network analysis and describe them from a clinical point of view.
Conclusions: This is the first study ever conducted with a comprehensive analysis of the disease patterns of psoriatic patients. Our results are a comprehensive map of possible psoriasis-related comorbidities. Further studies should confirm these associations and their pathophysiological relationship with psoriasis, which could help to detect and prevent comorbidities and modifiable risk factors.
Cathrine S Christiansen, Sigurd Høye, Morten Lindbaek, Jon Anders Halvorsen, Louise Emilsson
BJGP Open. 2025 May 20:BJGPO.2024.0211. doi: 10.3399/BJGPO.2024.0211.
Abstract:
Background: Acne is common and associated with negative psychosocial
health and risk of permanent skin alterations. General practitioners (GPs)
prescribe the main portion of antibiotics used for acne. Increased isotretinoin
prescription by GPs can potentially reduce overall antibiotic use, but
prescription practice and trends are unknown.
Conclusion: GPs reduced their prescription of tetracyclines, still our data shows potential for further improvements in prescribing practice. Increased isotretinoin prescription by GPs may lead to reduced antibiotic use and better treatment regimens for moderate-severe acne.
Michael J Diaz, Jasmine T Tran, Run Q Gan
Arch Dermatol Res. 2025 May 20;317(1):770. doi: 10.1007/s00403-025-04230-x.
No abstract available
Economic Impact of Allergic Diseases and Asthma-The HEAD Pan-European Registry
Ioana Agache, Maria Torres, Ibon Eguiluz-Gracia, Elena Bradatan, Kamal El Abd, Maria Beatrice Bilo, Federica Rivolta, Andrea Sangalli, Roxana Bumbacea, Selda Ali, Dario Antolin, Águeda Concepción Lario Cuenda, Vicente Albéndiz, Maria Miguel Oliveira, Paulo Jorge Nogueira, Loreto Carmona; HEAD Study Group
Allergy. 2025 May 20. doi: 10.1111/all.16596. Online ahead of print.
Abstract: The Health Economics of Allergic Diseases (HEAD) registry is a European-based registry developed by the European Academy of Allergy and Clinical Immunology in collaboration with national allergy societies to facilitate standardised allergic disease management. Using an observational design, this first registry-based study describes care patterns for allergic diseases and their impact on the healthcare system (diagnostic and management costs), society (missed work/school days and disability pension/support) and patients (out-of-pocket costs) in 778 adults and children with allergic rhinitis, asthma, atopic dermatitis and food allergy, from four countries (Belgium, Italy, Romania and Spain). The average total costs per patient and per year were €1329.55 ± 1947.39, with indirect costs of €338.68 ± 1629.61. Direct costs consisted of €82.74 ± 585.90 for hospitalisations, €17.50 ± 125.07 for the emergency department, €172.94 ± 323.17 for specialists, €22.70 ± 132.42 for primary care, €4.85 ± 136.84 for psychologists, €21.24 ± 82.47 for diagnosis and €104.81 ± 469.26 for treatments. Indirect costs were out-of-pocket consultation fees (€16.24 ± 106.40), medications (€161.90 ± 710.58), transportation (€44.15 ± 218.51), private insurance (€16.77 ± 157.91), avoidance (€8.65 ± 92.99) and environmental control (€99.33 ± 955.23). Adults missed 1.02 ± 3.20 workdays, children missed 0.53 ± 2.18 schooldays and burdened their families with 1.38 ± 13.83 lost days. There was a high degree of heterogeneity across countries for management patterns and for costs. The significant burden of allergic diseases calls for immediate action for better management.
Herpes zoster and dementia risk
Shih-Wei Lai, Kuan-Fu Liao
J Prev Alzheimers Dis. 2025 May 8:100198. doi: 10.1016/j.tjpad.2025.100198. Online ahead of print.
No abstract available
Michael J Diaz, Jasmine T Tran, Run Q Gan
Clin Exp Dermatol. 2025 May 16:llaf223. doi: 10.1093/ced/llaf223. Online ahead of print.
No abstract available
Lisa P van der Rijst, Edward F Knol, Nicolaas P A Zuithoff, Constance F den Hartog Jager, Femke van Wijk, Marjolein S de Bruin-Weller, Marlies de Graaf
Clin Exp Allergy. 2025 May 15. doi: 10.1111/cea.70082. Online ahead of print.
Abstract conclusion: Our findings provide insight into the distinct local and systemic proteomic changes in response to dupilumab treatment in paediatric AD patients. These findings underscore the complementary roles of tape strips and serum in profiling immune and epidermal barrier proteins, highlighting the utility of minimally invasive tape stripping for monitoring proteomic responses to targeted therapies in paediatric AD.
The Impact of Diagnostic Delay on Wound Healing-A Cohort Study in a Primary Care Setting
K M Ahmajärvi, K M Isoherranen, T J Pessi, M A Venermo
Int Wound J. 2025 May;22(5):e70141. doi: 10.1111/iwj.70141.
Abstract: The impact of diagnostic delays on wound healing has not been investigated in the primary care setting. The aim of this cohort study was to examine how diagnostic delays influence the healing of a chronic wound. This is a retrospective study on patients who were assessed by a specialized wound care team of a primary health care unit, aiming to reduce diagnostic and treatment delays among patients with chronic wounds. The data consist of 197 consecutive patients who had their first appointment with the wound care team in 2016. Patients whose wounds had appeared less than one year prior to the diagnosis (n = 182) were included in the analyses. Primary and secondary outcome measures: The primary outcome measure was wound healing and its association with a diagnostic delay. Delays were categorized into three groups by the date of the diagnosis: (1) less than 4 weeks (n = 33), (2) 4-12 weeks (n = 94) and (3) over 12 weeks (n = 55) after the appearance of the wound. A diagnostic delay had a significant effect on the wound healing time. Wounds had a shorter healing time if they were diagnosed early. The cumulative healing rate at 12 weeks was 54.5% in Group 1, 17.0% in Group 2 and 0% in Group 3. And 62.5% of the arterial ulcers and 47.8% of the diabetic ulcers were diagnosed within 4-12 weeks. Most of the venous leg ulcers were diagnosed within 4-12 weeks (54.2%). Our data clearly show that the earlier the diagnosis, the shorter the healing time in a primary care setting. The wounds that were diagnosed the earliest were mainly post-traumatic and venous leg ulcers. On the other hand, wounds requiring prompt diagnosis, such as diabetic foot ulcers and arterial ulcers, were not included in the group of early diagnosis. We conclude that a speedy diagnosis and aetiology-driven treatment of a wound has a direct impact on the wound healing time. Therefore, it is essential to improve the diagnostic pathways from the onset of the wound, starting from the primary care setting.
Kate L A Dunlop, Nehal Singh, Amelia K Smit, April L Morrow, Julia Steinberg, Anne E Cust, Meredith Makeham, Carissa Bonner, Bronwyn Terrill, Lynn V Monrouxe, David Wilkinson, Shailendra Sawleshwarkar, Alan S Ma
Front Med (Lausanne). 2025 Apr 30:12:1577958. doi: 10.3389/fmed.2025.1577958. eCollection 2025.
Abstract Discussion: While PCPs are optimistic about genomics, long-standing barriers to delivery in primary care remain. Multifaceted, evidence-based education strategies, including interactive components to change behaviour, will help to address barriers. Clarifying the role of PCPs, referral pathways, and collaboration with tertiary genetics services will further build capacity for genomics delivery in primary care.
Edmond Démoulins, Heloïse Schmeltz, Aurélie Gaultier, Jean Michel Nguyen, Gaëlle Quereux, Brigitte Dreno, Ludovic Martin, Cédric Rat
J Eur Acad Dermatol Venereol. 2025 May 14. doi: 10.1111/jdv.20726.
No abstract available
Arabella Baker, Natalie Bonsu, Laura Howells, Ingrid Muller, Eleanor J Mitchell, Fiona Cowdell, Firoza Davies, Mars Eddis-Finbow, Alan Montgomery, Devin Patel, Goldie Putrym, Matthew J Ridd, Miriam Santer, Amanda Roberts, Kim S Thomas; Rapid Eczema Trials team
Skin Health Dis. 2025 Apr 16;5(2):130-139. doi: 10.1093/skinhd/vzaf005. eCollection 2025 Apr.
Abstract conclusions: This paper provides a useful model for co-producing RCTs with members of the public. It describes the key stages of trial development (prioritization, intervention development, trial design) and contains information on the time and resources required to design trials using this approach.
Mie Sylow Liljendahl, Kristina Ibler, Christian Vestergaard, Lone Skov, Pavika Jain, Jan Håkon Rudolfsen, Ann Hærskjold, Mathias Torpet
Acta Derm Venereol. 2025 May 13:105:adv42250. doi: 10.2340/actadv.v105.42250.
Abstract: Atopic dermatitis is a chronic skin disease, causing itching and recurrent eczematous lesions. In Danish national register data, adults with atopic dermatitis can only be identified if they have a hospital-diagnosed atopic dermatitis. The purpose of this study was to develop a machine learning model to identify all patients with atopic dermatitis by proxy, using data for contacts with primary care, prescription medication, and hospital contacts not related to skin diseases. Individuals redeeming a prescription for dermatological preparations were extracted as potential patients with atopic dermatitis. Individuals with a registered hospital diagnosis of atopic dermatitis were classified as "Known AD", "Other skin disease" (registrations of other dermatological diagnosis codes indicating other skin disease), or "Uncertain AD status"' (no hospital diagnosis registered). Patients categorized as "Known AD" and "Other skin disease" were used to develop the model. All uses of healthcare services 2 years prior to hospital diagnosis were used as potential predictors. The data were split into training and validation sets (70/30). From 1996 to 2022, 385,135 individuals had uncertain atopic dermatitis status. The most important predictors were corticosteroid prescriptions for dermatological use, consultations with dermatologist, and age. Of the 385,135 individuals, the model predicted that 230,522 individuals likely have atopic dermatitis.
Klaudia Knecht-Gurwin, Adam Gurwin, Magdalena Łyko, Tomasz Drewa, Wojciech Kielan, Agnieszka Mastalerz-Migas, Rafał Stojko, Jacek C Szepietowski, Lukasz Matusiak
J Clin Med. 2025 May 3;14(9):3171. doi: 10.3390/jcm14093171.
Abstract conclusions: This large, first-of-its-kind global survey highlights substantial gaps in HS recognition, particularly among non-dermatologist clinicians. The findings underscore the urgent need for targeted, multidisciplinary educational interventions to improve diagnostic accuracy, reduce delays, and ultimately enhance patient outcomes in HS.
Emilia Räisänen, Anita Remitz, Alexander Salava
Acta Derm Venereol. 2025 May 12:105:adv43041. doi: 10.2340/actadv.v105.43041.
Abstract: The burden of atopic dermatitis has been increasing in Finland during recent decades and seems to vary seasonally. The aim was to investigate the effect of season and weather factors on patient numbers of primary care. Data bank information of the Finnish Institute for Health and Welfare was analysed for frequency of atopic dermatitis patients in the primary care of Helsinki during 2018-2023. In addition, the seasonal burden was compared with weather data from the Finnish Meteorological Institute. Patient numbers varied significantly during the year (p = 0.028). There was a recurrent seasonal variation with most atopic dermatitis diagnoses in January, February, March, and November and the least in July and August. A significant inverse association was observed between atopic dermatitis patients and outside temperature (p = 0.004) and UV Index (p = 0.008). Low air quality was associated with a higher burden in primary care (p = 0.013). There was no significant association regarding rain (p = 0.103) or relative air humidity (p = 0.392). The burden of atopic dermatitis in primary care shows a significant seasonal variation. There are specific weather parameters that follow similar patterns and likely comprise important extrinsic pathogenetic factors. It is reasonable to address the changing burden of atopic dermatitis with seasonally directed medical measures, education, and resources.
Anna Laine, Paula Muilu, Hannu Kautiainen, Kari Puolakka, Vappu Rantalaiho
Rheumatol Adv Pract. 2025 Apr 10;9(2):rkaf039. doi: 10.1093/rap/rkaf039. eCollection 2025.
Abstract conclusion: A substantial proportion of incident PsA patients are purchasing DMARDs before the ID, which may reflect the difficulty of setting a PsA diagnosis or may represent the treatment of severe skin psoriasis. PsA patients use more painkillers than their matched controls 1 year preceding the diagnosis. Prolonged opioid use is particularly evident among patients using psychiatric medications.
Development and Validation of a Disease Severity Index for Patients with Cold Urticaria
Tatjana Altunergi, Manuel P Pereira, Sabine Altrichter, Annika Gutsche, Dalia M Ahsan, Lena Fox Cand, Eva Grekowitz, Hanna Bonnekoh, Karsten Weller, Marcus Maurer, Pascale Salameh, Dorothea Terhorst-Molawi
J Allergy Clin Immunol Pract. 2025 May 8:S2213-2198(25)00416-7. doi: 10.1016/j.jaip.2025.04.047.
Abstract conclusion: The SICU is the first validated disease-specific PROM for assessing ColdU disease severity. This PROM will facilitate patient care, by evaluating disease severity and consequently better informing physicians and patients on an appropriate therapeutic approach.
Tobias E Sangers, Marlies Wakkee, Folkert Moolenburgh, Tamar Nijsten, Marjolein Lugtenberg
BMC Cancer. 2025 May 9;25(1):851. doi: 10.1186/s12885-025-14244-3.
Abstract conclusions: Although HCPs perceive pivotal risks related to the implementation of mHealth apps, they also foresee important benefits when implemented successfully. In order for HCPs to endorse those apps, emphasis must be placed on integrating accurate mHealth apps with accessible and inclusive design and functionality into clinical practice, factors that currently appear to be largely unmet.
The efficacy of apremilast in pemphigus: a systematic review of case reports
Roudin Hussain Alhasawi, Esraa A Shaheen, Noura Mohammed Alshabanat, Reem Brashi, Walaa Abdu Ahmed, Shumukh Hassan Alqahtani, Ethar Alharbi, Mazin Aljabri
Dermatol Reports. 2025 May 7. doi: 10.4081/dr.2025.10245.
Abstract: Pemphigus is a severe autoimmune blistering disorder that significantly affects patients' quality of life. While corticosteroids and immunosuppressive agents are commonly used, they have substantial side effects, highlighting the need for safer alternatives. Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, has shown efficacy in treating other autoimmune diseases and may offer promise for pemphigus. This systematic review evaluated the clinical outcomes, safety, and potential role of apremilast in pemphigus treatment by synthesizing available case reports and series. A literature search was conducted across multiple databases (PubMed, EMBASE, Cochrane, Web of Science, ScienceDirect, and Google Scholar) for case reports and series involving apremilast in pemphigus. Inclusion criteria were a confirmed pemphigus diagnosis and apremilast treatment. Five studies (four case reports and one case series) involving seven patients were included. Apremilast led to significant clinical improvement in four patients, with reductions in disease activity, lesion severity, and symptom scores (Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, Visual Analog Scale, and Numerical Rating Score). Increases in regulatory T cells and decreases in anti-desmoglein antibodies were observed. No serious adverse events were reported, although one study noted treatment failure, possibly due to short follow-up or concurrent infections. Apremilast appears to be a promising treatment for therapy-resistant or corticosteroid-intolerant pemphigus patients. Although the evidence is limited, it supports apremilast's efficacy and favorable safety profile. Further research with larger sample sizes and randomized controlled trials is necessary to confirm these findings.
Bryan E Hull, Carmin I Smoot, Adriene Pavek, Annabelle Huntsman, Shreya Sreekantaswamy, Julia Curtis
Med Ref Serv Q. 2025 May 8:1-14. doi: 10.1080/02763869.2025.2498117.
Abstract: Primary care providers and medical students often receive limited dermatologic education, leading to delayed diagnosis and treatment for patients with cutaneous conditions. Additionally, dermatology education has historically focused on light skin, neglecting skin of color, which exacerbates diagnostic delays and treatment disparities. The University of Utah's Eccles Health Sciences Library and Department of Dermatology, along with Oregon Health & Science University, developed Utah Dermatology Education Resources & Modules (UtahDERM) to address these educational gaps. UtahDERM features a custom-built slide-viewer platform with clinical dermatology images, diagnoses, clinical characteristics, and textbook references, along with a quick reference tool for core dermatology diagnoses.
Rimaz Sami Alyahya, Maha A AlHasson, Mnahal A Ali Alhsaon
Cureus. 2025 Apr 5;17(4):e81759. doi: 10.7759/cureus.81759. eCollection 2025 Apr.
Abstract: Cosmetics and personal care products are essential for personal hygiene and appearance; however, their safety remains a key concern due to associated adverse effects. This systematic review aims to evaluate the adverse effects and safety concerns related to skincare products and to analyze product characteristics and usage patterns for improved consumer safety. The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and adopted diverse database searches across PubMed, Medline, Google Scholar, and Scopus from 2014-2024. Only peer-reviewed and cross-sectional studies were included along with a data extraction sheet, and the Critical Appraisal Skills Programme (CASP) tool was utilized for quality assessment. Data synthesis involved descriptive and qualitative analysis to identify common themes and implications. Nine studies were included in the review, comprising 4,569 participants across geographically diverse regions. The common adverse effects reported included acne (36%), redness (27%), itching (19%), and skin irritation (18%). Ingredient analysis identified that fragrances, preservatives, and colorants are commonly related to adverse effects. Usage patterns like frequency and duration of usage were correlated with the likelihood of adverse effects. The review focused on significant adverse effects linked with cosmetic and personal care products, highlighting the necessity for better awareness, clear labels, and strict regulations. Enhanced customer education and following safety protocols are crucial to minimize risks and ensure product safety.
Seung-Kwon Myung, Yunseo Park
Am J Med. 2025 May 3:S0002-9343(25)00283-9. doi: 10.1016/j.amjmed.2025.04.034.
Abstract Background: Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.
Conclusions: There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.
Visualization of the Relationship Between Hyaluronic Acid and Wound Healing: A Bibliometric Analysis
Zhang Yue, Keke Shao
Skin Res Technol. 2025 Feb-May;31(2-5):e70164. doi: 10.1111/srt.70164.
Abstract Background: Wound healing is a complex process with significant economic implications. Hyaluronic acid (HA), valued for its adaptability and biocompatibility, shows the potential to improve multiple facets of wound healing. Despite the expanding literature on the use of HA in wound care, a comprehensive analysis of its scholarly evolution is lacking. This study employs a bibliometric approach to objectively evaluate trends in scholarly publications regarding HA's role in promoting wound healing.
Conclusion: This pioneering study provides the first comprehensive bibliometric analysis of HA in wound healing. Covering the period from January 1, 2000 to March 31, 2024, it reveals a significant expansion in annual scholarly production. Current research emphasizes the development of HA-based biomaterials for enhancing wound healing.
Hair Loss in Teenagers: A Review for Primary Care Pediatricians
Samantha Garcia, Brandi Kenner-Bell
Pediatr Ann. 2025 Jun;54(6):e189-e195. doi: 10.3928/19382359-20250321-01. Epub 2025 Jun 1.
Abstract: Adolescence is a critical developmental period marked by physical, psychological, and social changes, and hair loss can significantly impact self-esteem. Delays in treatment are common, and they sometimes result in permanent hair loss. This article reviews the most common causes of hair loss in adolescents (eg, androgenetic alopecia, alopecia areata, telogen effluvium, traction alopecia, trichotillomania). Key diagnostic approaches include thorough history taking and scalp examination. Management strategies range from pharmacological management to lifestyle modifications and behavioral therapies. Early identification and treatment, patient education, and understanding indications for referral are crucial for optimal clinical and psychosocial outcomes. This review emphasizes the importance of a primary care physician's initial evaluation and management of adolescent hair loss.
Andrew Nicholas, Alan B Fleischer, Steven R Feldman
J Am Acad Dermatol. 2025 Jun 4:S0190-9622(25)02232-7. doi: 10.1016/j.jaad.2025.05.1440.
No abstract available
Stephen P Merry, Ivana T Croghan, Kimberly A Dukes, Brian C McCormick, Gerard T Considine, Michelle J Duvall, Curtis T Thompson, David J Leffell
J Prim Care Community Health. 2025 Jan-Dec:16:21501319251344423. doi: 10.1177/21501319251344423.
Abstract:
Objectives: To evaluate the performance of noninvasive, elastic scattering spectroscopy, algorithm-powered device (DermaSensor) to detect melanoma and basal and squamous cell cancers in the primary care setting.
Conclusions: The DermaSensor device is an easy-to-use, point-of-care, hand-held skin cancer adjunctive diagnostic device with high sensitivity and NPV to help inform PCP decision-making about skin lesions suspicious for cancer that need further evaluation and those that may be monitored.
Jana Arsenjeva, Priit Kruus, Riina Hallik, Secil Matasova, Laura Prett, Katrin Kaarna, Liisi Raam, Oliver Taul, Liis Ilves, Kaisa Viljar, Pille Konno, Peeter Ross, Külli Kingo
J Med Internet Res. 2025 Jun 3:27:e73664. doi: 10.2196/73664.
Abstract:
Objective: This study aims to evaluate the feasibility and effectiveness of remote psoriasis monitoring at both primary and specialist care levels, and to identify factors associated with improved outcomes in primary care.
Conclusions: This study is the first to compare remote psoriasis monitoring across specialist and primary care levels. While remote management proved effective in specialist care, outcomes in primary care were nonsignificant, reflecting patterns seen in in-person PCP-led care. Using public claims data, the study highlights that integrating specialist support into PCP-led care via standardized e-consultations may enhance patient outcomes. It underscores the need for further research and the development of standardized collaborative care models between PCPs and specialists in the remote management of psoriasis.
Sex, intimacy and psoriasis: A qualitative study exploring young people's experiences
Jaclyn Yizhen Tan, Tori Ford, Abigail McNiven, Tess McPherson
J Eur Acad Dermatol Venereol. 2025 Jun 3. doi: 10.1111/jdv.20756. Online ahead of print.
No abstract available
Samip Sheth, Karla Inestroza, Joseph F Merola, Brittany Weber, Michael Garshick
J Psoriasis Psoriatic Arthritis. 2025 May 28:24755303251337020. doi: 10.1177/24755303251337020.
Abstract: Patients with psoriasis (PsO) and psoriatic arthritis (PsA) are at significantly increased risk for cardiovascular (CV) disease, attributed to chronic systemic inflammation and a high burden of cardiometabolic comorbidities. Despite this, CV risk factors in this population are frequently underdiagnosed and undertreated. This consensus document, developed by the Psoriasis and Psoriatic Arthritis Clinics Multicenter Advancement Network (PPACMAN), provides practical recommendations for dermatologists, rheumatologists, and primary care physicians to improve CV risk assessment and management in PsO and PsA. Key recommendations include conducting baseline CV risk assessments at diagnosis-particularly for patients with moderate-to-severe PsO, PsA, or those requiring biologic therapy-and routine screening for hypertension, diabetes, dyslipidemia, smoking, obesity, and metabolic syndrome. The use of biomarkers such as high-sensitivity C-reactive protein and lipoprotein(a) may help refine risk stratification. Patients at elevated risk should be referred to their primary care provider or a cardiologist for further evaluation and may require additional imaging, including coronary artery calcium scoring. Lifestyle counseling on diet, exercise, weight management, and smoking cessation is essential. Pharmacologic strategies, such as earlier initiation of statins and consideration of glucagon-like peptide-1 (GLP-1) receptor agonists, are encouraged when clinically appropriate. Systemic inflammation should be reduced using anti-inflammatory therapies, although outcome data remain mixed. Clinicians must carefully assess the risks and benefits of NSAIDs, corticosteroids, and Janus kinase (JAK) inhibitors. This document aims to bridge existing gaps in interdisciplinary care and facilitate earlier, more aggressive CV risk management in psoriatic disease, aligning with current cardiology and dermatology guidelines to reduce morbidity and mortality.
Annika Smith, Belinda Lai, Clara K Chow, Sarah Zaman
Australas J Dermatol. 2025 Jun 2. doi: 10.1111/ajd.14528. Online ahead of print.
Abstract:
Background and study aims: Patient perspectives on psoriasis as a systemic disease, with its heightened risk of cardiovascular disease (CVD), are unclear. Approaches to cardiovascular risk factor screening and management vary in this cohort. This study aimed to ascertain knowledge, practice and perceptions of patients with respect to psoriasis and CVD, CV risk factor screening and management.
Conclusion: There is a need for improved patient education regarding the relationship between psoriasis and CVD. Heightened awareness around cardiovascular risk may serve as an impetus for patients to seek relevant cardiovascular risk factor screening, management and pursue healthy lifestyle behaviours.
Rebekka Nordahl Larsen, Niels Kvorning Ternov, Kristian Kidholm, Tine Vestergaard
JMIR Dermatol. 2025 May 30:8:e66782. doi: 10.2196/66782.
Abstract:
Objective: This study aimed to investigate whether teledermoscopy can shorten the diagnostic process for physicians examining skin lesions suspected of skin cancer.
Conclusions: Our research suggests that the implementation of teledermoscopy could save time for dermatologists and potentially plastic surgeons and pathologists, provided that a sufficient number of benign skin lesions can be accurately diagnosed and excluded from further examination and treatment. In contrast, the implementation of teledermoscopy might prolong primary care providers' consultation time.
Rachel A Charlton, Emer Gates, Laura C Coates, James Galloway, Neil McHugh, Anita McGrogan, Simon Hackett, Melanie Brooke, Charlotte Cavill, William Tillett
Ann Rheum Dis. 2025 Jun;84(6):970-978. doi: 10.1016/j.ard.2025.02.020. Epub 2025 Mar 29.
Abstract:
Objectives: This study aimed to compare time to diagnosis among patients with psoriatic arthritis (PsA) with that of patients with rheumatoid arthritis (RA) and compare initial treatment and outcomes.
Conclusions: Compared with patients with RA, patients with PsA have a longer duration of symptoms before referral and a longer interval between presentation to the GP and receiving a diagnosis. Most people agreed a treat-to-target strategy but fewer DMARDs were commenced for patients with PsA than those for patients with RA and a lower improvement in disease activity was achieved at 3 months, suggesting undertreatment.
Annika Smith, Belinda Lai, Sarah Zaman, Peter Wong, Fiona Foo, Katy J L Bell, Pablo Fernandez-Penas, Clara K Chow
Australas J Dermatol. 2025 Jun;66(4):e187-e196. doi: 10.1111/ajd.14436. Epub 2025 Feb 22.
Abstract:
Background: Psoriasis is a risk factor for cardiovascular disease (CVD). This risk is independent and incremental to traditional cardiovascular (CV) risk factors, but clinician and patient perspectives on this risk are unclear. This study aims to assess the knowledge, perceptions, and practice of clinicians and patients with respect to psoriasis and CVD.
Conclusion: Clinician and patient knowledge of the relationship between psoriasis and CVD needs to be improved. The establishment of a national consensus approach to address this gap in clinical care is needed.
The Ethics of Teaching Primary Care Physicians to Perform Skin Biopsies
Nidhi Kuchimanchi, Gabrielle Schwartzman, Barrett J Zlotoff, Jane M Grant-Kels
J Am Acad Dermatol. 2025 Jun 11:S0190-9622(25)02295-9. doi: 10.1016/j.jaad.2025.06.018.
No abstract available
Sophie Blaise, Patricia Senet, Sylvie Meaume, Chloé Geri, Julie Malloizel, Monira Nou Howaldt
J Wound Care. 2025 Jun 2;34(6):389-396. doi: 10.12968/jowc.2025.0142. Epub 2025 May 27.
Abstract: Venous leg ulcers (VLUs) affect 1% of individuals in developed countries, posing a significant public health challenge due to complications, patient disability and healthcare costs. While high compression (>40mmHg) is the gold standard, delays in vascular assessment often postpone the adapted treatment. The ankle-brachial pressure index (ABPI) is recommended to exclude peripheral arterial disease, but its availability and reliability may vary, particularly in patients with diabetes. Given these challenges, immediate mild compression (≤20mmHg) has been proposed as a first and safe interim approach before confirming venous aetiology through an assessment performed by a vascular physician. Studies show that mild compression prevents worsening venous hypertension and improves patient adherence compared to stronger compression. In this position paper, written by a group of expert physicians in the field of compression therapy, we propose a pragmatic approach to compression during the initial phase of leg ulcer management to optimise patient care and wound healing outcomes. Guidelines support early mild compression in the absence of arterial 'red flags' (most notably chronic limb-threatening ischaemia, CLTI), followed by an increase in compression once venous pathology is confirmed. In France, where only 6.5% of general practitioners perform ABPI, timely vascular assessment is often impractical, leading to delayed interventions. After clinical elimination of any contraindication(s) (such as CLTI, severe neuropathy and/or atypical ulcers with a lack of healing despite hypergranulation), an effective strategy should involve the immediate initiation of mild compression, conducting vascular assessment within 4-6 weeks, and transitioning to high compression if needed and if the patient is able to tolerate it. Hence, mild compression can also be beneficial for patients who do not tolerate high compression. Given the need to balance safety, efficacy and tolerance, mild compression can be a valuable first-line strategy before specialised intervention, and while waiting for ABPI measurement availability as part of a complete vascular assessment.