Primary Care Dermatology Literature July 2025
Skin Research in Primary Care
Caroline Salafia, Smita Banerjee, Jada G Hamilton, Elizabeth Schofield, Yuelin Li, David B Buller, Keith Hunley, Andrew L Sussman, Dolores D Guest, Kimberly A Kaphingst, Marianne Berwick, Jennifer L Hay
PEC Innov. 2025 Jun 7:7:100409. doi: 10.1016/j.pecinn.2025.100409. eCollection 2025 Dec.
Abstract objective: Given the promise of family communication to prompt cancer risk awareness, we examined how an offer for skin cancer genetic testing may prompt family cancer communication.
Conclusion: Findings highlight that an offer for skin cancer genetic testing may prompt aspects of family communication, such as discussion surrounding personal skin cancer risk.
Primary Care Providers Versus Abnormal Skin Lesions: Elastic Scattering Spectroscopy to the Rescue
Svetomir N Markovic
J Prim Care Community Health. 2025 Jan-Dec:16:21501319251347905. doi: 10.1177/21501319251347905. Epub 2025 Jun 29.
No abstract available
Mikolaj Swiderski, Sarah Lewis, Yana Vinogradova, Matthew J Ridd, Zenas Z N Yiu, Antonia Lloyd-Lavery, Vibhore Prasad, Sonia Gran
Br J Dermatol. 2025 Jun 19:ljaf237. doi: 10.1093/bjd/ljaf237. Online ahead of print.
Abstract background: Several population-based studies have reported an increased risk of serious skin conditions following COVID-19 vaccinations, but their population samples were not representative. Accurately estimating these risks is important for informing vaccine hesitancy and clinical practice.
Conclusions: While the BP IR did not change following the vaccine programme, we detected increased HZ and urticaria IR. However, these increases were modest, and for many, the benefits of vaccination will likely outweigh the potential risks. Future research should use individual patient-level studies (e.g., self-controlled case series) to determine whether the increases in HZ and urticaria IRs are driven by COVID-19 vaccines.
Jiawen Deng, Eddie Guo, Heather Jianbo Zhao, Kaden Venugopal, Myron Moskalyk
Cancer Inform. 2025 Jun 24:24:11769351251349891. doi: 10.1177/11769351251349891. eCollection 2025.
Abstract objectives: Early skin cancer detection in primary care settings is crucial for prognosis, yet clinicians often lack relevant training. Machine learning (ML) methods may offer a potential solution for this dilemma. This study aimed to develop a neural network for the binary classification of skin lesions into malignant and benign categories using smartphone images and clinical data via a multimodal and transfer learning-based approach.
Conclusions: A transfer learning-based, multimodal neural network can accurately identify malignant skin lesions from smartphone images and clinical data. External validation with larger, more diverse datasets is needed to assess the model's generalisability and support clinical adoption.
Investigating the association between cataract and the risk of herpes zoster in a cohort study
Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao
Front Med (Lausanne). 2025 Jun 11:12:1492365. doi: 10.3389/fmed.2025.1492365. eCollection 2025.
Abstract conclusion: Our cohort study reveals that individuals with cataract are at an increased risk of developing herpes zoster. Our findings highlight the importance of considering the increased susceptibility to herpes zoster in individuals with cataract and the potential benefits of preventive measures such as herpes zoster vaccination.
Eduarda Castro Almeida, João Rocha-Neves, Ana Filipa Pedrosa, José Paulo Andrade
Diagnostics (Basel). 2025 Jun 14;15(12):1518. doi: 10.3390/diagnostics15121518.
Abstract background: Medical photography is widely used in dermatology referrals to secondary healthcare, yet concerns exist regarding image quality and data security. This study aimed to evaluate the quality of clinical photographs used in dermatology referrals, to identify discrepancies between specialties' perceptions, and to determine the general awareness of proper storage and security of clinical photographs.
Conclusions: The findings reveal a discrepancy between GFM doctors' and dermatologists' perceptions of photograph quality and information sufficiency in dermatology referrals. Standardized guidelines and educational interventions are necessary to improve the quality and consistency of clinical photographs, thereby enhancing communication between healthcare providers and ensuring patient data privacy and security.
Diarmuid Quinlan, Laura J Sahm, Linda O'Keeffe, Miriam Santer, Alison M Layton, Tony Foley
Br J Gen Pract. 2025 Jun 25:BJGP.2025.0135. doi: 10.3399/BJGP.2025.0135.
Abstract conclusion: This scoping review has identified the key clinical competencies that underpin safe management of people with acne using isotretinoin: dermatology, pregnancy prevention, mental health assessment and blood testing. Resourcing and supporting GPs to incrementally adopt this role may promote safe, timely and equitable patient access to isotretinoin, while enhancing antimicrobial stewardship.
Kay Edokpayi, Patricia Aluko, Flora Ka Kei Cheng, Darush Attar-Zadeh, Anne Dawson
J Prim Care Community Health. 2025 Jan-Dec:16:21501319251340836. doi: 10.1177/21501319251340836. Epub 2025 Jun 24.
Abstract results and conclusion: Majority (86%) tested negative. The questionnaire revealed that 67% could avoid GP visits. When extrapolated to the UK, this could result in an estimated annual saving of £263 million for the National Health Service (NHS) Despite not being recommended for routine use by NICE, the study suggests that such rapid diagnostic testing for Strep A, combined with FeverPAIN screening, could prevent antimicrobial misuse, alleviate NHS pressure and empower pharmacists. This is particularly relevant considering the recent implementation of the pharmacy-first service.
Management of hidradenitis suppurativa in UK primary care: cross-sectional survey
Hannah E Wainman, Stephanie Gallard, Matthew J Ridd, John R Ingram
BJGP Open. 2025 Jun 23:BJGPO.2025.0060. doi: 10.3399/BJGPO.2025.0060.
Abstract conclusion: Further education in diagnosing and managing HS in primary care is needed. Future research could focus on developing a tool to support the diagnosis of HS in primary care and a clear, primary care-focused management guideline for identified patients.
Klara Riber Eggers, Karen Mai Møllegaard, Laura Gregersen, Silja Hvid Overgaard, Zainab Hikmat, Torkell Ellingsen, Jens Kjeldsen, Andreas Kristian Pedersen, Sofie Ronja Petersen, Mohamad Jawhara, Anders Bathum Nexøe, Anette Bygum, Christian Lodberg Hvas, Jens Frederik Dahlerup, Frederik Olof Bergenheim, Henning Glerup, Jacob Broder Brodersen, Heidi Lausten Munk, Natalia Pedersen, Ole Haagen Nielsen, Karina Winther Andersen, Berit Lillenthal Heitmann, Robin Christensen, Vibeke Andersen
Scand J Immunol. 2025 Jun;101(6):e70035. doi: 10.1111/sji.70035.
Abstract: Biological therapy is used to treat chronic inflammatory diseases (CIDs); however, up to 50% of patients fail to achieve an adequate clinical response. This study aimed to access the impact of obesity on clinical treatment response in CID patients after 14-16 weeks of biological therapy. This multicentre prospective cohort study enrolled 233 adults between 2017 and 2020 diagnosed with Crohn disease, ulcerative colitis (UC), rheumatoid arthritis, axial spondyloarthritis (PsA), psoriatic arthritis or psoriasis scheduled for biologic therapy. The main analysis population included patients with BMI data before treatment initiation, categorising patients as either obese (BMI ≥ 30 kg/m2) or non-obese (BMI < 30 kg/m2). The primary endpoint was the proportion of patients achieving clinical treatment response after 14-16 weeks. Main analyses were based on logistic regression with a factor for obesity, while adjusted for sex and age. Of the 228 patients eligible for the main analyses, 125 (55%) responded to biologic therapy. In the obese group (n = 59), 30 (51%) patients responded compared to the 95 (56%) individuals categorised as non-obese (n = 169), with no difference between groups (OR: 0.82, 95% CI: 0.43 to 1.60). This study did not find a lower likelihood of response to biologics in obese individuals compared with non-obese counterparts.
Yuan-Liang Wen, Wan-Ting Hsu, Yi-Hsien Chen, Hui-Han Kao, Chun-Cheng Liao, Sheng-Yin To, Hui-Wen Yang, Li-Ting Kao
Br J Dermatol. 2025 Jun 20;193(1):74-84. doi: 10.1093/bjd/ljaf086.
Abstract Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i), a novel class of antidiabetic medication, have emerged as a key treatment option in diabetes management. Notably, SGLT2i promote glucose and sodium excretion through urine, a mechanism that may be implicated in the potential association between SGLT2i use and risk of atopic dermatitis (AD).
Objectives: To investigate the relationship between SGLT2i use and new-onset AD in people with diabetes.
Conclusions: SGLT2i show a significant protective effect against AD in patients with diabetes compared with DPP4i. This robust finding, consistent across weighting and sensitivity analyses, supports SGLT2i use, with a strong protective effect also found in the dose-response analysis.
Prevalence trends and risk factors for allergic rhinoconjunctivitis, asthma and eczema in the UK
Lavanya Diwakar, Anuradhaa Subramanian, Divya K Shah, Sumithra Subramaniam, Victoria S Pelly, Sheila Greenfield, David Moore, Krishnarajah Nirantharakumar
Allergy Asthma Clin Immunol. 2025 Jul 7;21(1):31. doi: 10.1186/s13223-025-00975-2.
Abstract objectives: Using a UK primary care database, we estimated the trends in prevalence over the last decade for ARC, asthma and eczema and associated risk factors.
Conclusion: The population burden of ARC, asthma and eczema in the UK is substantial. These conditions are often associated with other allergies and can, therefore, be complex to manage. These data support calls for improvement of pathways of care for allergy patients in the UK.
Getting the Full Picture: Nurses Use Video Visits to Enhance Telephone Triage for Homebound Patients
Barbara Squeri, Jennifer Huang, Silvia Chavez, Sarah Nowlin
Home Healthc Now. 2025 Jul-Aug;43(4):206-212. doi: 10.1097/NHH.0000000000001354.
Abstract: This pilot project evaluated nurse-led video visits as an adjunct to telephone triage in home-based primary care. Video visits were facilitated by community health workers (CHW), a telehealth coordinator, and Wi-Fi enabled tablets on a video visit platform. Data were collected and analyzed for visit type, indication, and characteristics. More than half were CHW-facilitated, with skin complaints as the most common reason. Video visits allowed nurses to better understand the patient situation than telephone triage alone. CHW-facilitated visits took longer but yielded more assessment information. Nurses involved in this project found nurse-led video visits a beneficial tool in better understanding the total clinical and social picture of older adults in our home-based primary care practice when compared to telephone triage alone.
Michael Hindelang, Alexander Zink, Johannes Knitza, Robert Darkow, Martin Welcker, Tilo Biedermann, Susann May, Felix Muehlensiepen
BMC Health Serv Res. 2025 Jul 2;25(1):894. doi: 10.1186/s12913-025-13043-7.
Abstract objective: This study investigates the acceptance, perceived usefulness, and potential barriers to using digital health services, such as medical apps and video consultations, among patients with CU and their healthcare providers.
Conclusion: While many patients and physicians recognize the potential of digital health technology to improve urticaria management, some remain uncertain or skeptical. Addressing concerns and improving digital understanding is critical to the future implementation and integration of these technologies into care. Due to the cross-sectional design of the study and the self-reported data, further research may be needed to confirm these results.
Lisa P van der Rijst, Edward F Knol, Nicolaas P A Zuithoff, Constance F den Hartog Jager, Femke van Wijk, Marjolein S de Bruin-Weller, Marlies de Graaf
Clin Exp Allergy. 2025 Jul;55(7):552-563. doi: 10.1111/cea.70082. Epub 2025 May 15.
Abstract objective: This study investigates local and systemic immune-related proteins in tape strips and serum of paediatric atopic dermatitis (AD) patients treated with dupilumab, and explores their correlation with clinical severity.
Conclusion: Our findings provide insight into the distinct local and systemic proteomic changes in response to dupilumab treatment in paediatric AD patients. These findings underscore the complementary roles of tape strips and serum in profiling immune and epidermal barrier proteins, highlighting the utility of minimally invasive tape stripping for monitoring proteomic responses to targeted therapies in paediatric AD.
AI-assisted Diagnosis of Nonmelanoma Skin Cancer in Resource-Limited Settings
Spencer Ellis, Steven Song, Derek Reiman, Xuan Hui, Renyu Zhang, Mohammad Hasan Shahriar, Maria Argos, Mohammed Kamal, Christopher R Shea, Robert L Grossman, Aly A Khan, Habibul Ahsan
Cancer Epidemiol Biomarkers Prev. 2025 Jul 1;34(7):1080-1088. doi: 10.1158/1055-9965.EPI-25-0132.
Abstract background: Early and precise diagnosis is vital to improving patient outcomes and reducing morbidity. In resource-limited settings, cancer diagnosis is often challenging due to shortages of expert pathologists. We assess the effectiveness of general-purpose pathology foundation models (FM) for the diagnosis and annotation of nonmelanoma skin cancer (NMSC) in resource-limited settings.
Conclusions: Our study highlights the important role FMs may play in confronting public health challenges and exhibits a real-world potential for machine learning-aided cancer diagnosis.
Lorenzo Blandi, Paola Bertuccio, Carlo Signorelli, Helmut Brand, Timo Clemens, Cristina Renzi, Anna Odone
J Prev Alzheimers Dis. 2025 Jun;12(6):100167. doi: 10.1016/j.tjpad.2025.100167.
Abstract background: Herpes Zoster is caused by the reactivation of the Varicella-Zoster Virus. Zoster may influence the occurrence of dementia, but contradictory results about this association emerged from recent studies. These findings did not consider the severity of Zoster and observed individuals for limited follow-up time. Our study used a region-wide Italian registry to investigate the association between severe Zoster infection and dementia occurrence over a 23-year period.
Conclusions: Our population-based study found an increased risk of developing dementia among severe Zoster cases. Those results support the importance of improving Zoster prevention and extending the vaccination recommendations to younger age groups.
Lija James, Louise Hailey, Christine Bundy, Helen Burstow, David Chandler, Russ Cowper, Philip Helliwell, Lucille Joannes, Andy Kelly, Bronagh Kennedy, Suzannah Kinsella, Helen McAteer, Sandeep Mukherjee, Jon Packham, Elspeth Wise, Helen Young, Emma Dures, Laura C Coates
Rheumatology (Oxford). 2025 Jul 1;64(7):4335-4340. doi: 10.1093/rheumatology/keae680.
Abstract objectives: Little is known about the ideal service delivery model and shortcomings in patient experiences in the NHS for patients with psoriatic arthritis (PsA). The objective of this work was to identify unmet needs perceived within the current health service delivery model for PsA from the UK Psoriatic Arthritis Priority Setting Partnership (PsA-PSP).
Conclusion: The five key themes provide valuable insights into the important areas of interest within health service delivery in the UK. By understanding these themes, policymakers, healthcare providers and researchers can better prioritize their efforts and address the specific care needs of people with PsA, their care providers and clinicians.
Alexandro W L Chu, Paul Oykhman, Xiajing Chu, Daniel G Rayner, Sukhdeep Bhangal, Andrew Dam, Janice Xu, Javed Sheikh, Kathryn P Trayes, Winfred T Frazier, David M Lang, Lisa A Beck, Sameer K Mathur, Susan Waserman, Lehana Thabane, Rachel N Asiniwasis, Lauren Runyon, Joseph Moellman, Eric T Oliver, Jeffrey Chan, Emily F Cole, Diane R Baker, David A Khan, Moshe Ben-Shoshan, Kathryn E Wheeler, Sanaz Eftekhari, Donna D Gardner, Tonya Winders, Maisie Flindall, Jamie Tattrie, Jonathan A Bernstein, Sarbjit S Saini, Derek K Chu
J Allergy Clin Immunol. 2025 Jul 11:S0091-6749(25)00646-3. doi: 10.1016/j.jaci.2025.06.004.
Abstract Background: Chronic urticaria is a common skin condition characterized by itchy wheals (hives), angioedema, or both, lasting for 6 weeks or more. Beyond antihistamines, multiple systemic treatments are available, but there is uncertainty regarding their comparative effects on chronic urticaria outcomes.
Conclusions: Among individuals with chronic urticaria refractory to antihistamines, standard-dose omalizumab and remibrutinib are among the most effective drugs across multiple patient-important outcomes with a favorable safety profile across the studied duration. Cyclosporine may be effective but may be among the most harmful. Dupilumab improves itch and wheals, but it is uncertain whether it improves angioedema or quality of life. Lower doses of omalizumab are of intermediate effectiveness and favorable safety. The net benefit of conventional immunosuppressants is uncertain.
Kim Thomas
Hi everyone
Just wondering if you would be willing / able to help spread the word about these discussion groups. We’d love to hear from as many people as possible.
Interested in improving eczema management?
Are you interested in using new technology to improve clinical practice? We are looking for healthcare professionals working in primary care to join a discussion about implementation of a new photo assessment technology (www.EczemaNet.co.uk) to improve eczema management.
To find out more and sign-up, please see information here (https://shorturl.at/Nl43T)
All attendees will receive a £20 shopping voucher.
Any question, please contact:
Reiko Tanaka r.ta...@imperial.ac.uk
Filip Paszkiewicz f.pasz...@imperial.ac.uk
Thanks a lot
Kim
Professor Kim Thomas
Professor of Applied Dermatology Research
Co-Director of Centre of Evidence Based Dermatology
ORCID: 0000-0001-7785-7465
We are now part of the NIHR School for Primary Care Research (SPCR)
Established in 2006, with latest membership revised in 2021, the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR) is a partnership between nine leading academic centres for primary care research in England. The SPCR’s main aim of increasing the evidence base for primary care practice, is achieved through high quality research and strategic leadership. For more information on our programmes of research and training, please visit our website: spcr.nihr.ac.uk
t: +44 (0) 115 84 68632
w: www.nottingham.ac.uk/dermatology
Follow us
twitter.com/cebdnottm
.
sandra lawton
On 21 Aug 2025, at 13:04, 'Kim Thomas' via Skin Research in Primary Care <sapc-skin-r...@googlegroups.com> wrote:
Hi everyone
Just wondering if you would be willing / able to help spread the word about these discussion groups. We’d love to hear from as many people as possible.
Interested in improving eczema management?
Are you interested in using new technology to improve clinical practice? We are looking for healthcare professionals working in primary care to join a discussion about implementation of a new photo assessment technology (www.EczemaNet.co.uk) to improve eczema management.
To find out more and sign-up, please see information here (https://shorturl.at/Nl43T)
All attendees will receive a £20 shopping voucher.
Any question, please contact:
Reiko Tanaka r.ta...@imperial.ac.uk
Filip Paszkiewicz f.pasz...@imperial.ac.uk
Thanks a lot
Kim
Professor Kim Thomas
Professor of Applied Dermatology Research
Co-Director of Centre of Evidence Based Dermatology
ORCID: 0000-0001-7785-7465
<image001.png>
We are now part of the NIHR School for Primary Care Research (SPCR)
Established in 2006, with latest membership revised in 2021, the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR) is a partnership between nine leading academic centres for primary care research in England. The SPCR’s main aim of increasing the evidence base for primary care practice, is achieved through high quality research and strategic leadership. For more information on our programmes of research and training, please visit our website: spcr.nihr.ac.uk
t: +44 (0) 115 84 68632
w: www.nottingham.ac.uk/dermatology
Follow us
twitter.com/cebdnottm
.
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