EC numbers and reaction ids

[Deepa]

Hello Everyone,

For certain reactions, I find multiple EC numbers

http://sabiork.h-its.org/newSearch?q=sabioreactionid:575 

  D-Mannose + ATP = ADP + D-Mannose 6-phosphate is annotated with EC numbers 

2.7.1.1, 2.7.1.2 in Homo sapiens.

Could someone explain why there are multiple EC numbers? 

Thanks a lot,

Deepa

[Rey, Maja]

Hello Deepa,

 

One reaction can be catalyzed by various enzymes belonging to distinct enzyme classes. We usually link the reaction to the EC-number which is appropriate according to the publication the data are originating from.

 

In your case it’s one specific enzyme (UniprotID P35557) which is nowadays defined to be a general hexokinase (2.7.1.1) but is sometimes also mentioned to be a glucokinase (2.7.1.2).

 

Best regards,

Maja

 

 

Dr. Maja Rey

Research Associate

Scientific Databases and Visualization

HITS gGmbH

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