Instead of formatting the file system inside s3backer using ext4, 
reiserfs, btrfs, ... has anyone tried using f2fs, the flash friendly 
file system.  It seems to me, at first glance, that this combination 
might work quite well, as the effort by f2fs to adapt to the native 
block size of a flash drive (which might be a megabyte or two), and to 
minimize the number of such blocks written, might work well when it's an
 "S3" based drive, rather than a "Flash" based drive.
(I earlier posted this same question at 
https://github.com/archiecobbs/s3backer/issues/75#issuecomment-281120963, and Archie replied, saying that he hadn't heard of anyone doing this, but that I might post this question here as well.)