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This is surprising because... well, we're just sitting and the vehicle's doing the work, right?
But:
Vehicles accelerate, brake, bump, turn, vibrate, ... and our muscles micro-adjust continously so we sit upright. Over hours hours, that's a lot of energy.
We feel like we're still. But the inner-ear fluids, eyes, etc. constantly get feedback about motion. That mentally drains us (and causes motion sickness).
Noise from vehicles, traffic, ... triggers cortisol, a stress hormone. That drains us.
Sitting in one place restricts blood flow and it pools in our legs, making the heart work harder.
In flights, the air pressure is low, lowering oxygen levels. The dehydration thickens our blood, making pumping harder.
What helps is:
Noise-cancelling headphones (reduces the rumbling / traffing sounds)
Compression socks (reduce blood pooling in the feet)