Robert Krahn has created a smalltalk-type environment for Clojure.
Try it out in the browser with demos and lots of info:
http://cloxp.lively-web.org/cloxp.html
His talk from this Spring at Clojure West:
https://www.youtube.com/watch?v=qQvvgzvPgQI
I haven’t tried it locally yet, but just played around with the browser version. Looks promising, even if the JVM has some limitations compared to a true smalltalk VM.
Cheers,
Jamie