Correct way to group the mice samples based on the haplotype of a single location

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Saikat Bandyopadhyay

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Apr 29, 2025, 11:01:22 AMApr 29
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I am analyzing bulk RNA seq data generated from the DO. I have genotype information for these and I have performed QTL analysis for some skeletal traits. 

There are some of the locus with interesting QTL associations, I am wondering how can I efficiently group the mice based on the haplotype of the locus and perform DESeq kind of comparison. 

I wantt to do this for a specific locus or a group of locus, for example for a locus on chrosome1:152-155 Mb. I would really appriciate the suggestions.
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