Sk Gupta Biochemistry Pdf 29
Josefa Trimino
The Women in Biochemistry and Molecular Biology Committee advocates for women in biochemistry and molecular biology, both in academia and in industry by increasing participation, visibility and status of women within the scientific community. Learn more about the ASBMB's work supporting women in BMB
Meghna Gupta started as an Assistant Professor in the Department of Chemical Physiology and Biochemistry on February 1, 2024. Dr. Gupta specializes in biochemistry and structural analysis of membrane proteins using cryo-electron microscopy (cryo-EM). She expanded her research interest towards fatty-acid metabolism and cell biology of peroxisomes as a postdoctoral researcher at the University of California San Francisco (UCSF) through her K99/R00 pathway to independence award from the National Institute on Aging (NIA)/NIH.
The Gupta Lab broadly focuses on delineating the role of membrane proteins in human health and disease. One of her major projects is studying peroxisome biogenesis disorders and assessing the involvement of peroxisomes in metabolic, genetic, and age-related diseases. The program encompasses biochemistry, biophysics, and assay development for molecular characterization of macromolecules of interest. The lab will utilize the power of imaging at various scales including optical microscopy, cryo-EM, and cryo-electron tomography (cryo-ET) to correlate molecular events and their cellular and physiological context.
The research is a nationwide collaborative effort. It brings together experts in molecular biology (Ramsden) and cancer cell biology (Gaorav Gupta, MD, PhD, assistant professor in the UNC School of Medicine Department of Radiation Oncology and UNC Lineberger member), biochemistry (Richard Wood, PhD, MD Anderson Cancer Center, Houston), structural biology and mechanism (Sylvie Doubli, PhD, University of Vermont, Burlington) and biophysics (Eli Rothenberg, PhD, Perlmutter Cancer Center, New York).
Scientists are always on the lookout for new and better approaches to fighting cancer, which is where developing a targeted POLQ inhibitor is of interest. To date, there has been little known, both in normal cells and cancer cells, about the structure, mechanism of action, and the biological role of this enzyme. The lack of basic biological knowledge of how POLQ works led to the awarding of this grant.
The scientists have postulated POLQ would be an advantageous target because it becomes essential only in combination with certain tumor-specific contexts. Most intriguingly, the researchers already have data that shows that potential therapies directed at POLQ could improve the effectiveness of PARP inhibitors for the treatment of certain types of breast cancer.
Because of the depth of expertise involved, the team will cast a wide net in their work. The researchers originally thought that hereditary, BRCA1/2-deficient breast and ovarian cancers would be the primary targets of a POLQ therapy. But even though their work is just beginning, they believe that up to 30% of all breast cancers (not just those that are BRCA1/2 deficient), and perhaps other cancers could benefit from treatment with a POLQ-based therapy.
Welcome to the Gupta College of Science, your premier destination for a comprehensive STEM (Science, Technology, Engineering, Mathematics) education. Our college's foundation is built upon a strong and distinctive liberal arts core, innovative and relevant STEM programs, and the integration of nationally recognized high-impact practices (HIPs) to enrich experiential learning.
As the largest college within Coastal Carolina University, we take pride in offering an impressive array of 13 distinctive undergraduate degree programs, covering diverse fields from biochemistry to psychology. We also provide 15 focused concentrations that allow students to develop expertise alongside their degrees, along with 18 minors and one certificate program to further customize their education. For those pursuing advanced studies, we present two master's degree programs and one doctoral program.
One of the factors that set our students apart is the extraordinary experiences they gain throughout their academic journey. Our nationally recognized HIPs open up a world of opportunities, enabling students to actively engage with faculty in cutting-edge research and outreach through our esteemed centers and initiatives.
Additionally, we offer three dual-degree options, and for those interested in the MBA program offered by the Wall College of Business, our Coastal Marine and Wetlands Studies track presents an enriching pathway.
Hello! I'm Sagar, a biochemistry, biology, and biophysics triple major and chemistry submatriculant (B.A./M.S.) passionate about research and scientific communication. I work in Dr. Nikolaos Sgourakis's lab at the Children's Hospital of Philadelphia, where I conduct structural immunology research. Outside of research, I'm involved with Moelis Access Science (MAS), PennScience Journal, and CURF Undergraduate Advisory Board.
I want to help students navigate the rich academic community at Penn and love connecting students with labs and mentors that are a good match for them. Feel free to email me if you have any questions about the research process at Penn!
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