In my view the main problem we have right now in my view is that we have a few intrusive behaviours on ROOT, which means that we modify the behaviour of it. That could cause problems for other libraries which were written against PyROOT and don't expect the new behaviours we add. Ideally, we shouldn't affect the behaviour of any code unless it directly imports rootpy (or gets passed a rootpy-flavoured object). This might be a good target for a 1.0 release.
I would say, give it a go, but exercise due caution and try to make it break before depending on it for massive infrastructure right now.
And if you find problems, by all means please let us know [1]!
All the best,
- Peter
[1]
https://github.com/rootpy/rootpy/issues/new