It also depends if that ActiveX/COM object exposes any non-UI functionality via COM API method calls. If it did, you can automate some functionality through those via Python COM interface (or Java/.NET COM interface, but not via Jython I think). But if all there is to it is the ActiveX GUI object, you're stuck using GUI means to automate.
And that basically means:
* AutoIt
* Sikuli or other image recognition tool
* Microsoft's native UIAutomation support via .NET
If AutoIt isn't sufficient, then White is the next best option to evaluate. Unfortunately, to my knowledge, no one has yet wrapped White in a RF library (via IronPython or as pure .NET/C# library), so you'd have to do it yourself for the keywords you need.