There are a bunch of problems with using it for ALE including the fact that processors don't agree on the timing, direction or even which pins are multiplexed. 65C816 for example it's going to provide you A23-A16, some processors it will switch between address/data and others it will switch between A7-A0/A15-A8.
I did ponder putting ALE on a user pin for 8080/85 when I did the boards as it wouldn't be hard and it could overlap the E and RW usage as the 680x/HC11 whilst multiplexed really needs the lines buffered on the CPU card anyway to avoid ground bounce problems.
I don't know of any cards using \RFSH though and I think only the classic Z80 card even reliably provides it as the Z180 boards turn it off on boot up. As a CPU specific weirdness I just don't see why you'd put it anywhere but a user pin. Certainly none of my other CPU cards generate \RFSH and I've never met anything that even connected it.
It's also really easy to interface a muxed bus expecting device to the standard rcbus in most cases, and then everyone can use it. Both the PC style RTC and the 80 column video card actually use chips that expect a multiplexed bus (but not quite the same one) and both work with any CPU card because they handle it on the card instead.
Alan