I had only designed a couple of PCBs before taking up retro homebrew computers. I've now designed about 30 boards.
I have watched a couple of online videos about PCB design from people who really seem to know what they are doing. I also have some ancient knowledge of the PCB production process. From this and what 30 boards worth of experience has shown me, I'd make the following comments.
I don't use auto-routing. I tried it on my first recent board but didn't like the results. I prefer manual routing to get a better quality result but also to make the design more interesting. I find it quite rewarding fiddling about with the layout. It's an art form :)
Via holes are a weak link. If you go for really small hole diameters, which seems to be the default these days, they are tricky to plate well. Think about how it works. A small hole is drilled which leaves about 1.6mm of insulating material which needs plating over. With a small hole, access, even for a liquid, is pretty restricted. Beats me how they get plated at all. Spending time to move tracks about and reduce the number of via holes is a good idea, but running tracks all around the houses to avoid a via is also bad news. Surprisingly I've not yet seen any evidence with my boards that vias have failed.
More recently I've been experimenting with larger via holes to further reduce risk of failure. The problem here is the pads around the vias also get bigger which quickly impacts the amount of space used by a group of tracks.
I rarely use tracks narrower than 10 mil. Using unnecessarily narrow tracks also creates weak links. A tiny bit too much etching and the track can be eaten away. Also, a wider track is mechanically stronger (and more likely to survive when that screwdriver slips!). Using wider tracks than electrically necessary also reduces resistance and heating effects, which is no bad thing. Using wide tracks does also mean they can end up with less space between them, which can be bad. I set the DRC minimum spacing to a value higher than the defaults to ensure I leave good size spaces. So in summary, I don't push my luck on any of the claimed production capabilities.
Another thing I've recently been trying to do is reduce the number of tracks on the solder side that go between IC pins. I do this to avoid the potential fear an inexperienced maker may have when space around a solder joint has tracks in it. For the same reason, I also set the copper fill rules to leave more space around the solder side pads. This may be a silly idea, but it does make the solder side look and feel less cluttered, and I think reduces the change of solder shorts, etc.
I'm careful to ensure good placement of decoupling (bypass) capacitors. I try to have the power feed go to the capacitor and from there only to the chip pin. On the return path, I manually route a track to the ground pin to ensure a short route and then allow the copper fill to further improve the ground.
I think PCB design is a simple process when only very low-frequency signals are involved. It gets more difficult as the frequencies increase, so I'll stick to relatively slow retro tech.
Learning is a never-ending process and I fully expect to be experimenting with board design for some time to come.
Steve