Berberine sulfate is used clinically in Asia to treat diarrheal infections. In one double-blind placebo-controlled trial, 400 mg doses of berberine sulfate were given orally to men with E. coli -induced diarrhea. The group receiving the berberine had a 48% reduction is stool volumes, and 42% of the men in the group stopped having watery stools within 24 hours, compared with 20% in the control group, who received only a placebo. The results are typical of treatment of diarrhea with berberine. This trial is frequently cited by herbal companies as "proof" that berberine-containing plants kill bacteria in the intestine, even though the authors of that trial reach the opposite conclusion. They found that pathogenic bacterial counts in the patients were unchanged (Rabbani et al 1987). Berberine in such high doses (the equivalent of about 26 capsules of goldenseal) did not appear to disrupt the pathogenic bacteria, much less the beneficial ones.