Still a work in progress, but I have been talking to Ben about this a bit offline, and I think the short answer may be that, at present, you will not be able to download files larger than 2 GB if you are running PHP on a 32 bit server platform.
There may be a partial workaround for this. But no matter what I don't think it will be possible to work with files larger than 4GB without a 64 bit server. So my general feeling is that if you expect to work with files this large, you should probably upgrade to 64 bit.
It might be possible to work out a solution that would let RS support up to 4 GB on 32 bit systems, although I think this would require a change to the download mechanism, perhaps in a way that would somewhat reduce the security checks. This would require a bit more study.
I do think that no matter what we may need to tweak the system to make it a bit more clear what these limitations are. This could perhaps happen during upload, and should definitely be a part of the installation check.