Done, and happily running 2.0.403 on my VM.
Here's how I did it:
1) Mount the DVD ISO image under /mnt and copy system.sfs elsewhere:
# mount -o loop Remix_OS_for_PC_64bit_B2016071101.iso /mnt
# mkdir /tmp/rebuild
# cp -a /mnt/system.sfs /tmp/rebuild
# cd /tmp/rebuild
# unsquashfs system.sfs
# mv squashfs-root/system.img /tmp/rebuild
At this point, you can pause and root system.img or proceed with the injection.
The current directory should be similar to this listing:
# ls -la
total 3490248
drwxr-xr-x 9 root root 4096 Nov 28 23:16 .
drwxr-xr-x 3 root root 4096 Nov 28 23:20 ..
drwxr-xr-x 3 root root 4096 Jul 11 12:15 boot
drwxr-xr-x 2 root root 4096 Jul 11 12:15 .disk
drwxr-xr-x 4 root root 4096 Jul 11 12:15 efi
-rw-r--r-- 1 root root 12 Jul 11 12:15 info.ini
-rw-r--r-- 1 root root 4941230 Jul 11 12:15 initrd.img
-rw-r--r-- 1 root root 3405041 Jul 11 11:30 install.img
drwxr-xr-x 2 root root 4096 Jul 11 13:05 isolinux
-rw-r--r-- 1 root root 5205456 Jul 11 11:37 kernel
-rw-r--r-- 1 root root 1155361 Jul 11 11:55 ramdisk.img
-rw-r--r-- 1 root root 467 Jan 14 2016 Readme.txt
-rw-r--r-- 1 root root 2393 Jan 14 2016 rootx.sh
drwxr-xr-x 2 root root 4096 Nov 28 22:57 squashfs-root
drwxr-xr-x 2 root root 4096 Jan 14 2016 su
-rw-r--r-- 1 root root 2684354560 Nov 28 22:57 system.img
-rw-r--r-- 1 root root 874881024 Jul 11 12:57 system.sfs
drwxr-xr-x 2 root root 4096 Jul 28 2015 tmp
-rw-r--r-- 1 root root 2196 Jul 11 13:05 TRANS.TBL
2) With the VBox VM turned off, mount its HD using 'nbd':
# modprobe nbd max_part=16
# qemu-nbd -c /dev/nbd0 /shared/vbox0/VM/RemixOS_2/disk1.vdi
# mount -t ext4 /dev/nbd0p1 /mnt
3) Inject the new (2.0.403) files into that filesystem:
# rsync -avP system.img initrd.img kernel ramdisk.img /mnt
4) Cleanup
# umount /mnt
# qemu-nbd -d /dev/nbd0
5) Reboot your RemixOS VM and enjoy.
Tested using 2.0.205 (upgraded to 2.0.403).
My 2c,
Vincent