Genome scaffolding using Hi-C data

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l.p.p...@gmail.com

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Oct 2, 2017, 1:54:53 PM10/2/17
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Dear Redundans users, 

Over last winter I've developed genome assembler for Hi-C libraries (https://github.com/lpryszcz/HiCembler). It works quite well already, tested it on Arabidopsis, some public fish data (400Mb) and human. It runs on human data, but has problems with proper chromosome number estimation... And does some mistakes, that I could try to solve. Unfortunately don't have enough motivation to polish it. Do you have access to some ongoing genome projects with Hi-C data? 

btw: I even run de novo assembly & scaffolding on Hi-C data alone. it works, but you loose 10-20% of the genome (I guess heterochromatin regions). This could be recovered post-assembly, but never got into it properly... 

Just bunch of ideas :)
L.
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