Three ordinary 13-year-old girls, Momoko Akatsutsumi, Miyako Gōtokuji, and Kaoru Matsubara, are engulfed in white light, which transforms them into Hyper Blossom, Rolling Bubbles, and Powered Buttercup, the Powerpuff Girls Z. Peach is also engulfed in white light, transforming into a toy dog who can talk and call the girls to transform. Numerous rays of black light engulf people, animals, and objects to transform them into evil monsters who want to take over Tokyo City, such as Mojo Jojo, Fuzzy Lumpkins, Princess Himeko, Sedusa, the Gangreen Gang and the Amoeba Boys. The Powerpuff Girls Z must protect Tokyo City with the help from the Professor, Ken, Mayor Mayer and his assistant, Ms. Bellum, and use their respective weapons, including Blossom's yo-yo, Bubbles' bubble rod and Buttercup's hammer from evil monsters.
After three years of manageable peace, the girls didn't think they would get a new member of the team. They also didn't expect hormonal, superpowered teenage boys, a mystery little girl, and love to be thrown in the mix. However, maybe this weird change can be just what they need or maybe it's just a mess waiting to happen?!
Plot: Four girls from completely separate universes find themselves stranded on a mysterious planet called Chromia. They have no choice but to work together and discover the mysteries that Chromia has to offer!
The main trio: In General Left to right: Kaoru, Momoko, Miyako
- Adaptation Species Change: In the original series, the girls were artificial humans. Here, they're just regular human girls.
- Adaptational Curves: The girls infamously lack ears, noses, proper joints, and digits in the original cartoon. They have them all here, in addition to more developed bodies due to their Age Lift from kindergartners to eight graders.
- Adaptational Skimpiness: They wear white stockings under their dress in the original cartoon. In this anime their legs are exposed since they wear leotards with magically attached Minidress of Power (in the literal sense of the word).
- Adaptational Wimp: They can only use their powers once they transform, and even then it's limited. Compare to the original girls who always have access to their wide variety of powers.
- Age Lift: They are around 13 in this continuity, when they were five-year-olds in the source material. Considering the years between the original cartoon and the anime adaptation were released (1998 and 2006, respectively), the anime girls are actually what the age the original girls would be had they aged in real life.
- Balloon Belly: All three girls stomachs inflated in "The Way of the Noodle."
- Blonde, Brunette, Redhead: Momoko/Blossom is the Redhead, Miyako/Bubbles is the Blonde, and Kaoru/Buttercup is the Brunette.
- Clark Kenting: Justified, as anyone wearing the clothes one of them gets during their Transformation Sequence will appear to be that girl implying that the clothes have some kind of disguising power. However, only six girls in the entire series wear that style of belt buckle...
- Clothes Make the Superman: Some of their powers come from their outfits. They become powerless when the RowdyRuff Boys steal their clothes resulting in the professor's amusing attempts to make them new super suits.
- Dub-Induced Plot Hole: The English Dub Name Change to their names from the original cartoon causes a huge Plot Hole since the girls have secret identities in this version and those names are instead their superhero Code Names. This made the Running Gag of them having to sneak off to transform and do heroics rather pointless.
- Early Installment Character-Design Difference: The girls' figure changes from the beginning. Towards the later episodes, the girls are portrayed with more curvaceous figures (as curvaceous as 13-14-year-old girls can get). In the early episodes, the girls are lean and slender. Perhaps this is meant to represent their developing pubescent bodies?
- Fighter, Mage, Thief: Blossom is the Thief, Bubbles is the Mage, and Buttercup is the Fighter.
- Henshin Hero: The trio uses a henshin belt and its accompanied trinket to transformed into their superhero forms.
- Related in the Adaptation: Unlike the original, Mojo Jojo uses their DNA to create the Rowdyruff Boys.
- Town Girls: The energetic, boy-crazy Otaku Surrogate Momoko/Blossom is the Neither, the proper and fashionable Miyako/Bubbles is the Femme and the rough Passionate Sports Girl Kaoru/Buttercup is the Butch.
- Unrelated in the Adaptation: Unlike in the original American cartoon (where the girls are sisters), the three Powerpuff Girls aren't related to each other in any way and the three were normal girls from the start rather than being artificially created by Professor Utonium and adopted as his daughters.
The second member of the Powerpuff Girls Z team. Miyako/Bubbles is the ditziest member of the three, often appearing a bit clueless, and doesn't seem to understand her powers completely, along with a few other things. She is, however, more mature than the other girls in the team and will try to calm any situation, although she too can be angered when provoked. She is also very polite and always uses honorifics at the end of names. She is more concerned with shopping, her appearance and her outfits, and perhaps because of this, she seems to be very popular among her male classmates.
She transforms using the phrase "Rolling Bubbles" and uses a bubble wand as a weapon.
- Action Fashionista: She's always concerned with shopping, her appearance and her outfits, and she's still a formidable fighter.
- Adaptation Personality Change: The original Bubbles was the most childish of the girls, here she's the most mature.
- Badass Adorable: Just like the original, but more tough and oh so cute.
- Beware the Nice Ones: She may seem innocent and naive, but she is no less dangerous than the other two.
- Big Fancy House: She lives in an ancestral Japanese house.
- Bouncy Bubbles: Her "Bubble Poyon" is a large bouncy bubble that prevents enemy attacks and absorbs shock for rescue.
- Bubble Gun: She fights using a giant bubble wand.
- Childhood Friend Romance: She has had a crush on her childhood friend Takaaki for years, although she only met him once due to him being hospitalized.
- The Cutie: Like before, she comes off as this because she is more innocent and naive than the others.
- The Ditz: Despite her being more mature, she hasn't really lost this trait, an example is that it takes her a whole day to clean anything in her Big Fancy House halfway through!
- Dub Name Change: Averted. In the English adaptation, she is known as "Bubbles" in both forms.
- Dub Personality Change: In the original Japanese dub, she's portrayed as an Indifferent Beauty and is the most soft-spoken of the three. In the English dub, she's much more hammy and child-like, making her more in line with her American counterpart.
- Dude Magnet: She is said to be the most popular girl in school and her locker is always full of love letters and gifts.
- Dumb Blonde: Though she's not that completely idiotic, she is known to occasionally be very ditzy, just like the original.
- The Fashionista: She loves her clothes.
- Girlish Pigtails: She has pigtails like the original Bubbles, though hers are styled into Ojou Ringlets. However, while she can be ditzy, at the same time she's also the most mature of the three.
- Girls Love Stuffed Animals: Has an Octi stuffed toy that she adores just like her American counterpart.
- Girly Girl: The most feminine girl of the team.
- Hair of Gold, Heart of Gold: A kind, feminine and helpful girl with blonde hair.
- The Heart: She is the most emotional girl of the team.
- How Do I Shot Web?: Bubbles initially uses her staff as a throwing weapon, until Blossom told her how to use it properly.
- "I Know You're in There Somewhere" Fight: With Octi in "It's All Because of Him."
- Indifferent Beauty: Miyako is the most popular girl at her school and never stops receiving love confessions from boys, but she doesn't care about any of that and ignores all the attention she gets in favor of pining after her childhood crush.
- The Ingenue: She is innocent and pure, but still every bit as tough as Blossom and Buttercup.
- Innocent Blue Eyes: She has blue eyes and is the most innocent of the three.
- Magic Staff: She has one that creates bubbles of varying uses.
- Nice Girl: She tends to be very polite and friendly.
- Ojou: She lives in a Big Fancy House, has impeccable manners and everyone respects her for her status and looks.
- Ojou Ringlets: Her hair is a bit curlier than her American counterpart.
- Pinky Swear: She made one with Takaaki, her childhood crush, promising that they would see each other again someday.
- Raised by Grandparents: She lives with her grandmother because her parents live elsewhere.
- Rescue Romance: She developed a crush on Takaaki after he defended her from a Gang of Bullies.
- Single-Target Sexuality: She ignores all the boys at her school and rejects the thousands of love confessions she gets from them because she's still pining after her childhood crush Takaaki, even though she only met him once.
- Single Woman Seeks Good Man: She developed a crush on Takaaki because he was the nicest and most sensitive boy she ever met. When she meets him again as a werewolf, she can recognize him because of his non-aggressive nature and how he goes out of his way to save children.
- Speaks Fluent Animal: She talks to animals.
- Squishy Wizard: She can create magic bubbles, but can still be vulnerable.
- Suddenly Fluent in Gibberish: She shocks her teammates when she starts talking to puppies while they're trailing Him.
- Swiss-Army Tears: In Episode 36, her tears are what bring the corrupted Octi back to normal and defeat Him.
- Town Girls: The Femme to Blossom's Neither and Buttercup's Butch.
- Trademark Favorite Food: Meatballs.
- True Blue Femininity: She wears blue and tends to be the most feminine of the team.
- Verbal Tic: "Desu wa" in the original dub. This only cements her status as a traditional Japanese girl.
- Water Is Womanly: Miyako is the most feminine girl on the team, being calm, mature, and sweet. She wears light blue clothes and fights using a bubble wand.
- Why Did It Have to Be Snakes?: Is afraid of insects, like Momoko.
- Yamato Nadeshiko: Mature, calm, very polite and always uses honorifics at the end of names. Her Big Fancy Japanese House seals the deal.