Bonine and Bonamine

[Johnn...@webtv.net]

Hello... I hear many talking about Bonine for seasickness. In Canada,
the only anti-nausea like this that I could find at the pharmacy is
"Bonamine" ..... Are they the same?

Thanks....Jon

[John & Lola]

Hi Jon, try Gravol, it works great for us.

Lola in Hamilton

[Tom & Linda]

Look at the active ingredient on the label. If it says meclizine 25mg,
it is.

--Tom

[LEON]

The real issue is the active ingredient. If it reads meclizine 12.5mg then it is  what you are looking for.

[Tom & Linda]

The U.S. Bonine pack says the dose is 25 mg of Meclizine Hydrochloride.

What I don't know is if the hydrochloride salt contributes another 12.5
mg or if the dosage outside of the US is a lower dose.

--Tom

[Punch]

wrote in <3655-3AA...@storefull-117.iap.bryant.webtv.net>:

goto the ship doctor, they have the patch, passengers seem to agree it
works. looks a little funny though!! and what about the tan line?

[OcnGypZ]

>Subject: Bonine and Bonamine

The active ingredient in Bonine is meclizine hcl 25 mg.

The patch is available only with prescription... and is contraindicated for
many people with various ailments.

Meclizine hcl is the safest you can take which is 100% effective.

[LEON]

if you ask for a sea sickness pill at the pursers desk of most good cruise lines they will give you a 25mg
pill of meclizine.
in fact this is more than an adequate dose and may make you unpleasanlty drowsy. the reason i mentioned 12.5mg
is that i have my own supply of this smaller dosage that was prescribed for me and i find it more than
adequate.
the in active ingredeint does not add the extra 12.5 silly!!!!!
The milligrams refer only to the active ingredient which as i said is meclizine. By the way it is auite easy
to break a 25mg pill in half. I would also suggest that if you imagine you be experiencing some nausea that
you give the Bonime a trial run just to make sure it does not make you too drowsy.

Leon

[Tom & Linda]

The hydrochloride in meclizine is not an inactive ingredient. It's most
likely a salt that is attached to the molecular structure that makes the
meclizine water soluble. That is often the case in pharmaceutical
products.

It's actually quite possible that meclizine is an insoluble material
(I'm not positive, I'm just guessing - Pfizer scientists would know for
sure). And it has a certain molecular weight. Adding the salt to part
of the chemical structure would do 2 things. Make it water soluble and
increase the molecular weight. But it's not an inactive ingredient,
it's part of the chemical structure.

So it is quite possible that one weight represents pure meclizine, while
the other represents the meclizine hydrochloride which is water
soluble. And therefore 2 different weights for the same product. One
is the weight of the powder, and the other is the equivalent weight of
just the part of the powder that works.

And hydrochloride isn't the only thing used to make compounds water
soluble. Sometimes you may see a sulfate, a bisulfate, sodium, a
phosphate, etc. after the active ingredient's name.

The "inactive" ingredients you mention serve to make the compound
compressible into a tablet form. Those are compounds like Avicel, corn
starch, etc., which have "rough edges" that grab and lock together when
you need to make a tablet. [tablet and capsule are the correct forms...
not "pill"] Inactive ingredients typically range from as low as 20% to
as much as 80% of the total tablet weight. But that's a whole different
thing.

The PDR of US pharmaceuticals (the 1999 edition I have at work) does not
show a 12.5 mg dosage. It only shows the 25 mg. But you can break the
tablet in half.

--Tom