Igenetics A Molecular Approach By Peter J Russell Free Download Pdf 295

[Terese Stallman]

The genomic and transcriptomic exploration of H. contortus provides new insights into the molecular biology of one of the most important parasites of small ruminants worldwide. This investigation has elucidated transcriptional alterations taking place throughout the life cycle, particularly during the transition from the free-living to the parasitic stages, and has emphasized molecules involved in host-parasite interactions and immune responses. Determining the genome sequence and transcriptomes of H. contortus can accelerate post-genomic explorations of genes and gene products involved in nematode development and reproduction, future proteomic and metabolomic studies, parasite-host interactions, and pathogenesis of disease. The characterization of the RNAi machinery for H. contortus also provides a solid platform for functional genomic work in selected stages of the parasite. Therefore, an integrated systems biology approach should provide novel strategies for parasite intervention via drugs, vaccines, and diagnostic tests. For instance, future work could focus on defining a spectrum of key molecules involved in pathways linked to the development of the nervous system in different stages of H. contortus, and assessing their potential as drug targets. Moreover, exploring unique groups of molecules, such as SCP/TAPS, TTLs, and the complex array of peptidases, and understanding the roles of these molecules in host-parasite interactions is likely to support the design of new interventions.

igenetics a molecular approach by peter j russell free download pdf 295
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